Results 231 to 240 of about 23,706 (334)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Dynamics of recombination, X inactivation and centromere proteins during stick insect spermatogenesis. [PDF]

PLoS Genet
Dumas Z, Toubiana W, Delattre M, Schwander T.   +3 more
europepmc   +1 more source

A study of the germ cells of certain diptera, with reference to the heterochromosomes and the phenomena of synapsis

, 1908
N. M. Stevens
openalex   +2 more sources

Non‐Volatile Phase Modulation with Ultralow Energy Consumption Enabled by 2D Ferroelectric/TMD Heterostructures

Advanced Science, EarlyView.
We demonstrate a hybrid WS2/CuInP2S6/graphene heterostructure integrated on a silicon nitride microring resonator for non‐volatile optical phase modulation with ultra‐low energy consumption and low insertion loss. While CIPS alone does not provide efficient optical index modulation, the engineered proposed device structure converts ferroelctric domain ...
Lalit Singh, Shi Guo, Yuhui Yang, Sholehin Juperi, Rui Yu, Xiangxin Gong, Jeremy Leong, Sung‐Gyu Lee, Qingyun Wu, Lay Kee Ang, Sang Hoon Chae   +10 more
wiley   +1 more source

BAF-1-VRK-1 mediated release of meiotic chromosomes from the nuclear periphery is important for genome integrity. [PDF]

Nat Commun
Paouneskou D, Baudrimont A, Kelemen R, Elkrewi M, Graf A, Moukbel Ali Aldawla S, Kölbl C, Tiemann-Boege I, Vicoso B, Jantsch V.   +9 more
europepmc   +1 more source

Al Nanoparticle‐Decorated Metal Oxide Synaptic Transistors for Ultralow‐Energy Neuromorphic Computing with Wide Dynamic Range

Advanced Science, EarlyView.
A nanoparticle‐engineered electrolyte‐gated memtransistor is introduced as a materials‐level strategy to overcome the intrinsic trade‐off between energy consumption and synaptic precision. By embedding aluminum nanoparticles at the oxide–electrolyte interface to modulate ion trapping dynamics, the device achieves stable multistate plasticity under ...
Jun‐Gyu Choi, Yoonseok Song, Seokhyeon Baek, Jingon Jang, Sungjun Park   +4 more
wiley   +1 more source

Single-molecule techniques in studying the molecular mechanisms of DNA synapsis in non-homologous end-joining repair. [PDF]

Biophys Rep
Jiang Y, Zhao C, Zhang C, Li W, Liu D, Zhao B.   +5 more
europepmc   +1 more source

Chromosome synapsis, recombination and epigenetic modification in rams heterozygous for metacentric chromosome 3 of the domestic sheep Ovis aries and acrocentric homologs of the argali Ovis ammon

, 2019
Tatiana Bikchurina, Е. К. Томгорова, Anna A. Torgasheva, В. А. Багиров, Н. А. Волкова, Pavel M. Borodin   +5 more
openalex   +1 more source

Cation‐Driven Valence Change Mechanism in 2D AgCrS2 for Ultralow‐Power and Reliable Memristors

Advanced Science, EarlyView.
A 2D AgCrS2 volatile memristor is shown to switch via a cation‐driven valence change mechanism, where Ag+ reversibly intercalates into tetrahedral vacancies between CrS2 layers to form a conductive Ag2CrS2 pathway without elemental Ag metallization. The device exhibits 0.2 V switching, nA‐compliance power down to 200 pW, and endurance beyond 3 × 105 ...
Yueqi Su, Minghao Wang, Xiaolin Tai, Yuhua Liu, Yue Lin, Yuqiao Guo, Jing Peng, Yi Xie, Changzheng Wu   +8 more
wiley   +1 more source

Overlapping and separable activities of BRA-2 and HIM-17 promote occurrence and regulation of pairing and synapsis during Caenorhabditis elegans meiosis. [PDF]

Nat Commun
Blazickova J, Trivedi S, Bowman R, Sivakumar Geetha S, Subah S, Scuzzarella M, Chang A, Chandran UR, Yanowitz JL, Smolikove S, Jantsch V, Zetka M, Silva N.   +12 more
europepmc   +1 more source