Results 231 to 240 of about 23,521 (333)

Decision letter: Cisplatin-induced DNA double-strand breaks promote meiotic chromosome synapsis in PRDM9-controlled mouse hybrid sterility

, 2018

openalex   +1 more source

Nasal Mucosa‐Derived Extracellular Vesicles as a Systemic Antiaging Intervention

Advanced Science, EarlyView.
This study shows that nasal mucosa‐derived extracellular vesicles (nmEVs) exert systemic anti‐ageing effects in mice by restoring circadian rhythm, suppressing cellular senescence, and improving cognitive function. In aged human bone marrow mesenchymal stem cells, nmEVs reverse senescence‐associated phenotypes and reactivate core clock gene expression.
Wentao Shi, Lu Bian, Mengyuan Yu, Jun Wang, Mingzhu Gao, Liping Shen, Xiao Zhang, Zhiliang Huang, Hong Tang, Long Lv, Yunduan Que, Zengli Miao, Xuechao Wu, Qing Wang, Xiaojie Lu   +14 more
wiley   +1 more source

Manipulating Engram Histone Acetylation Alters Memory Consolidation. [PDF]

Hippocampus
Watt L, Glauser L, Coda DM, Gräff J.
europepmc   +1 more source

Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model

Advanced Science, EarlyView.
Transplantation of medial ganglionic eminence (MGE) interneuron progenitors into APP/PS1 cortices restored the slow oscillation characteristic of Alzheimer's disease. Donor cells survived, migrated, and matured into functional GABAergic interneurons, forming synaptic connections.
Shinya Yokomizo, Megi Maci, April M. Stafford, Morgan R. Miller, Stephen J. Perle, Shuzo Inagaki, Shusaku Takahashi, Heather Brown‐Harding, Linda Liang, Alex Lovely, Moustafa Algamal, Rebecca L. Gillani, Theodore J. Zwang, Douglas Richardson, Janice R. Naegele, Daniel Vogt, Ksenia V. Kastanenka   +16 more
wiley   +1 more source

Chromosomal Roadblocks in Male Fertility: Mechanisms, Risk Factors and Syndromes. [PDF]

Medicina (Kaunas)
Mitrakas AG, Alexiadi CA, Gargani S, Alexiadis T, Alexopoulou SP, Pagonopoulou O, Lambropoulou M.   +6 more
europepmc   +1 more source

Controllable Charge Storability in InP/ZnSe Core/Shell Quantum Dots toward Bioinspired Optical Synaptic Application

Advanced Science, EarlyView.
A field‐effect transistor incorporating type‐I InP/ZnSe core–shell quantum dots demonstrates light‐ and gate‐tunable synaptic plasticity. By leveraging field‐assisted photoinduced charge trapping, the device emulates essential neuromorphic functions, including paired‐pulse facilitation, memory consolidation, and classical conditioning.
Guohao Wen, Bingbing Huo, Dingting Zheng, Xiang Zheng, Guanlin Ke, Zhiguo Chi, Honglei Wu, Botao Ji, Zhenhua Sun   +8 more
wiley   +1 more source

53BP1-RIF1 and DNA-PKcs show distinct genetic interactions with diverse chromosomal break repair outcomes. [PDF]

Nat Commun
Makins K, Cisneros-Aguirre M, Lopezcolorado FW, Stark JM.   +3 more
europepmc   +1 more source

Abrogation of synapsis exerts opposite effects on OLLAS::COSA-1 foci formation in male vs. hermaphrodite germ lines.

JoAnne Engebrecht (207461), Aashna Calidas (22478120), Qianyan Li (5920223), Angel Ruiz (6030242), Pranav Padture (22478123), Neeraj Bhavani Aniyan Bhavana (22478126), Consuelo Barroso (411488), Enrique Martinez-Perez (144292), Nicola Silva (5349767)   +8 more
openalex   +1 more source

Ex Vivo Spatiotemporal Characterization of Spermatogenesis in Mouse Testicular Organoids

Advanced Science, EarlyView.
To date, in vitro spermatogenesis remains a challenge in reproductive medicine. In this study, Sun et al. developed a promising in vitro strategy to generate testicular organoids that enable germ cells from newborn mice to enter meiosis, complete chromosome recombination and synapsis, and develop into haploid spermatids.
Jiachen Sun, Lifa Zhu, Yutong Li, Jinyan Tang, Tao Zhang, Hengjia Zhang, Wanchu Wang, Lufan Li, Shuhui Bian, Xin Wu   +9 more
wiley   +1 more source

In vitro reconstitution of SPO11-mediated DNA cleavage reveals mechanistic and clinical insights into meiotic DNA double-strand break formation. [PDF]

Clin Transl Med
Hu Z, Tang X, Tong MH, Huang Y.
europepmc   +1 more source