Results 261 to 270 of about 26,734 (323)

USP11‐PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA‐cGAS‐STING Pathway After Intracerebral Hemorrhage

Advanced Science, EarlyView.
This study reveals that the deubiquitinase USP11 stabilizes PGAM5, triggering neurotoxic astrocyte transformation after intracerebral hemorrhage. PGAM5 promotes mPTP opening and Drp1 dephosphorylation, synergistically amplifying mtDNA leakage into the cytosol and leading to cGAS–STING hyperactivation.
Jiaqing He, Zijuan Qin, Yaning Cai, Haixiao Liu, Tinghao Wang, Qing Hu, Yanni Xu, Pan Yang, Xun Wu, Yan Qu, Wei Guo   +10 more
wiley   +1 more source

STAG3‐mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis

EMBO Journal, 2014
Tomoyuki Fukuda, Nanaho Fukuda, Ana Agostinho, A. Hernández-Hernández, A. Kouznetsova, C. Höög   +5 more
semanticscholar   +1 more source

Engineering Bulk Photovoltaic Effect in 2D Transition Metal Dichalcogenides

Advanced Science, EarlyView.
Structural and phase engineering in two‐dimensional transition metal dichalcogenides (2D TMDs), through lattice distortion, phase transitions, and polarization modulation, to induce the bulk photovoltaic effect (BPVE) for optoelectronic and energy conversion applications.
Sikandar Aftab, Arden L. Moore
wiley   +1 more source

Alpha-synuclein interacts with regulators of ATP homeostasis in mitochondria. [PDF]

Nat Commun
Serdiuk T, Fleischmann Y, Ghosh D, Delparente A, Reber V, Frey L, Rhyner D, Gerez J, Volkmar N, Kralickova L, Mas G, Dörig C, Hiller S, Schibli R, Mu L, Picotti P, Riek R.   +16 more
europepmc   +1 more source

Logic Circuits Featuring Organic Electrochemical Transistors: What is the Logic Behind OECTs in Logic?

Advanced Science, EarlyView.
For bioelectronic applications, organic electrochemical transistors (OECTs), with their mixed ionic and electronic conduction, will be invaluable for interfacing with living systems. This review examines the latest research, which has shifted towards integrating OECTs in logic circuits capable of transducing and processing bio‐signals.
Lorenzo Travaglini, Kristina Fidanovski, Damia Mawad   +2 more
wiley   +1 more source

m⁶A Reader hnRNPA2B1 Modulates Late Pachytene Progression in Male Meiosis Through Post-Transcriptional Control. [PDF]

Adv Sci (Weinh)
Yin L, Zhang Y, Zhang B, Zhang J, Xiong M, Jiang N, Xiao J, Gao H, Xiong W, Wang X, Wang F, Yuan S.   +11 more
europepmc   +1 more source

CDKG1 protein kinase is essential for synapsis and male meiosis at high ambient temperature in Arabidopsis thaliana

Proceedings of the National Academy of Sciences of the United States of America, 2014
T. Zheng, Candida Nibau, D. Phillips, G. Jenkins, S. Armstrong, J. Doonan   +5 more
semanticscholar   +1 more source

Enhanced Protein Synthesis and Hippocampus‐Dependent Memory via Inhibition of YTHDF2‐Mediated m6A mRNA Degradation

Advanced Science, EarlyView.
YTHDF2‐mediated m6A mRNA decay critically regulates learning and memory. Its forebrain‐specific knockout in mice impedes degradation of m6A‐modified mRNAs, enhancing hippocampal synaptic transmission, protein synthesis, and memory. Conversely, hippocampal YTHDF2 reintroduction or SEMA4B reduction reverses this enhancement, while its overexpression ...
Kuan Li, Chen Guo, Xiaoli Wu, Cuiting Wu, Songfen Wu, Si Su, Min Wu, Xidan Zhou, Si Li, Yihui Cui, Tao Zhou   +10 more
wiley   +1 more source

Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis. [PDF]

Proc Natl Acad Sci U S A
Ito M, Yun Y, Kulkarni DS, Lee S, Sandhu S, Nuñez B, Hu L, Lee K, Lim N, Hirota RM, Prendergast R, Huang C, Huang I, Hunter N.   +13 more
europepmc   +1 more source

Polarity‐Controlled Volatile HfO2 Memristors with Bimodal Conductance for Neuromorphic Synapses and Reservoir Computing

Advanced Science, EarlyView.
This study demonstrates a TiN/HfO2/ITO memristor exhibiting field‐induced bimodal volatile switching behavior originating from ion bombardment during sputtering. The dipole‐driven, polarity‐dependent states produce multilevel output responses that expand the reservoir's output dimensionality and enhance encoding diversity.
Yuseong Jang, Chanmin Hwang, Myoungsu Chae, Taegi Kim, Hee‐Dong Kim   +4 more
wiley   +1 more source