Results 301 to 310 of about 26,216 (365)

Dynamics in Cre-loxP site-specific recombination. [PDF]

Curr Opin Struct Biol
Foster MP, Benedek MJ, Billings TD, Montgomery JS.   +3 more
europepmc   +1 more source

Compound Heterozygous Variants in ZSWIM7 Gene Linked to Infertility and Its Role in Gonadal Development

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT This study aims to elucidate the role of the ZSWIM7 gene in the etiology of infertility, focusing on its potential association with premature ovarian insufficiency and azoospermia. We investigated an 18‐year‐old female patient who presented with primary amenorrhea, hypoplasia of the uterus and ovaries, Tanner stage II breast and pubic hair ...
Denise M. Christofolini, Guilherme Pinn, Thainá Vilella, Maria I. Melaragno, Mariana Moysés‐Oliveira, Luciano Pompei, Rare Genomes Project Consortium, Bianca Bianco, Caio P. Barbosa   +8 more
wiley   +1 more source

Meiotic dynamics in a unique Australian marsupial provide new insights into the evolution of neo-sex chromosomes in the early stages of differentiation. [PDF]

Front Cell Dev Biol
Marín-Gual L, Hogg CJ, Chang JK, Pask AJ, Renfree MB, Waters PD, Ruiz-Herrera A.   +6 more
europepmc   +1 more source

Deficiency of DEK proto‐oncogene alleviates allergic rhinitis by inhibiting RhoA/Ezrin‐mediated mitochondrial fission

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the mechanism of DEK regulating RhoA activation Ezrin. Upon house dust mite (HDM) stimulation, HDM‐specific immunoglobulin E (IgE) and inflammatory factors such as interleukin 4 (IL‐4), IL‐5, IL‐13, and eosinophils increased in the nasal mucosa.
Longzhu Dai, Yongde Jin, Jingmei Chai, Jianing Yang, Jiangang Wang, Mu Chen, Liangchang Li, Chongyang Wang, Guanghai Yan   +8 more
wiley   +1 more source

Dynamic molecular architecture of the synaptonemal complex. [PDF]

Sci Adv
Köhler S, Wojcik M, Xu K, Dernburg AF.
europepmc   +1 more source

Effects of Dictyophora polysaccharide on cerebellar Purkinje cell degeneration in a chronic alcohol mouse model

Animal Models and Experimental Medicine, EarlyView.
In an ethanol (EtOH)‐treated mouse model, increases in the NLRP3 inflammasome proteins, PC degeneration, and motor coordination disorders were observed. DIP suppressed the NLRP3‐ASC‐caspase‐1 signaling pathway, and alleviated the motor deficits and cerebellar pathological changes in chronic EtOH‐treated mice.
Jian Zhang, Zhihui Dai, Huanhuan Yu, Baofei Sun, Jiuyang Ding, Yuanhe Wang   +5 more
wiley   +1 more source

Hypothesis that ancestral eukaryotes sexually proliferated without kinetochores or mitosis.

J Cell Sci
Akiyoshi B.
europepmc   +1 more source

Spherical harmonics texture extraction for versatile analysis of biological objects. [PDF]

PLoS Comput Biol
Gros O, Passmore JB, Borst NO, Kutra D, Nijenhuis W, Fuqua T, Kapitein LC, Crocker JM, Kreshuk A, Köhler S.   +9 more
europepmc   +1 more source

Green‐to‐red spectral labeling: A novel polysynaptic retrograde tracing strategy in the marker footprint mouse model

Animal Models and Experimental Medicine, EarlyView.
To compensate for the fluorescence loss in rabies virus–derived neuronal tracing tools caused by non‐cytolytic immune clearance (NCLIC) in retrograde tracing, we developed a novel green‐to‐red spectral labeling (GTR) strategy based on the NCLIC phenomenon and developed a novel marker footprints mouse to support the strategy.
Yige Song, Jinyu Zeng, Yunyun Han, Aodi He, Houze Zhu   +4 more
wiley   +1 more source

Multiple and Alternative Sites Make Tau Protein an Adaptable Sticky Surface for the SH3 Domain of Fyn Kinase

Angewandte Chemie, EarlyView.
An NMR‐based study, combined with computational, calorimetric and in‐cell FRET methods, sheds light on the complex recognition mechanism between the intrinsically disordered protein Tau and the SH3 domain of Fyn kinase, highlighting how the multiple binding sites present in Tau make the protein an adaptable recognition surface that can function even ...
Roberto Tira, Giulia Leo, Laura Prandini, Carlo Giorgio Barracchia, Mariapina D'Onofrio, Luca Mollica, Stefano Capaldi, Michael Assfalg, Francesca Munari   +8 more
wiley   +2 more sources