Results 31 to 40 of about 1,301 (201)

UDP‐glucose dehydrogenase variants cause dystroglycanopathy

Annals of Clinical and Translational Neurology, EarlyView.
Abstract UDP‐glucose dehydrogenase (UGDH) variants have been associated with hypotonia, developmental delay, and epilepsy. We report the first pathologic evidence of dystroglycanopathy in siblings with UGDH variants. Both presented around 6 months with developmental delay and elevated creatinine kinase.
Anna M. Reelfs, Carrie M. Stephan, Theresa M. Czech, Mary O. Cox, Soumya Joseph, Benjamin W. Darbro, Steven A. Moore, Kevin P. Campbell, Katherine D. Mathews   +8 more
wiley   +1 more source

A quality control mechanism coordinates meiotic prophase events to promote crossover assurance.

PLoS Genetics, 2014
Meiotic chromosome segregation relies on homologous chromosomes being linked by at least one crossover, the obligate crossover. Homolog pairing, synapsis and meiosis specific DNA repair mechanisms are required for crossovers but how they are coordinated ...
Alison J Deshong, Alice L Ye, Piero Lamelza, Needhi Bhalla   +3 more
doaj   +1 more source

The conserved AAA ATPase PCH-2 distributes its regulation of meiotic prophase events through multiple meiotic HORMADs in C. elegans.

PLoS Genetics, 2023
During meiotic prophase, the essential events of homolog pairing, synapsis, and recombination are coordinated with meiotic progression to promote fidelity and prevent aneuploidy.
Anna E Russo, Stefani Giacopazzi, Alison Deshong, Malaika Menon, Valery Ortiz, Kaori M Ego, Kevin D Corbett, Needhi Bhalla   +7 more
doaj   +1 more source

Recruitment of Polo-like kinase couples synapsis to meiotic progression via inactivation of CHK-2

eLife, 2023
Meiotic chromosome segregation relies on synapsis and crossover (CO) recombination between homologous chromosomes. These processes require multiple steps that are coordinated by the meiotic cell cycle and monitored by surveillance mechanisms.
Liangyu Zhang, Weston T Stauffer, John S Wang, Fan Wu, Zhouliang Yu, Chenshu Liu, Hyung Jun Kim, Abby F Dernburg   +7 more
doaj   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

ALD‐Assisted VO2 for Memristor Application

Advanced Engineering Materials, EarlyView.
This work demonstrates a strategy for depositing VOx using thermal atomic layer deposition (ALD) followed by thermal annealing to synthesize VO2. The thin film and core/shell wire memristors exhibit excellent switching performance and are highly sensitive to ambient temperature.
Jun Peng, Daniel Hensel, Rakshith Venugopal, Lucas Rave, Colin Schormann, Sebastian Koch, Robert H. Blick, Robert Zierold   +7 more
wiley   +1 more source

Physcion Mitigates LPS-Induced Neuroinflammation, Oxidative Stress, and Memory Impairments via TLR-4/NF-кB Signaling in Adult Mice

Pharmaceuticals
Alzheimer’s disease (AD) is the most predominant cause of dementia, considered a progressive decline in cognitive function that ultimately leads to death.
Sareer Ahmad, Kyonghwan Choe, Haroon Badshah, Riaz Ahmad, Waqar Ali, Inayat Ur Rehman, Tae Ju Park, Jun Sung Park, Myeong Ok Kim   +8 more
doaj   +1 more source

The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis

Nature Communications, 2019
During a process termed synapsis, the two DNA ends at a double-strand break (DSB) are brought together into physical proximity. Here, the authors use a single-molecule FRET approach with purified proteins to investigate the mechanism of synapsis in DSB ...
Bailin Zhao, Go Watanabe, Michael J. Morten, Dylan A. Reid, Eli Rothenberg, Michael R. Lieber   +5 more
doaj   +1 more source

Matefin/SUN-1 phosphorylation is part of a surveillance mechanism to coordinate chromosome synapsis and recombination with meiotic progression and chromosome movement.

PLoS Genetics, 2013
Faithful chromosome segregation during meiosis I depends on the establishment of a crossover between homologous chromosomes. This requires induction of DNA double-strand breaks (DSBs), alignment of homologs, homolog association by synapsis, and repair of
Alexander Woglar, Anahita Daryabeigi, Adele Adamo, Cornelia Habacher, Thomas Machacek, Adriana La Volpe, Verena Jantsch   +6 more
doaj   +1 more source

Constructing Covalent Organic Polymers through Dative B─N Bonds: Synthesis, Single Crystal Structures, and Physical Properties

Advanced Functional Materials, EarlyView.
Dynamic linkages are highly attractive in preparing single crystals of covalent organic polymers (COPs). Here, single crystals of two COPs CityU‐15 and CityU‐16 based on reversible B─N bonds are constructed using tetra(4‐pyridyl)tetrathiafulvalene and tetra(4‐pyridyl)porphine as monomers.
Xin Wang, Lei Zhang, Xiang Wang, Tianqi Cheng, Miaomiao Xue, Qiang Dong, Yungkang Peng, Qichun Zhang   +7 more
wiley   +1 more source