Results 41 to 50 of about 23,706 (334)

Dynamics of rye chromosome 1R regions with high or low crossover frequency in homology search and synapsis development. [PDF]

open access: yesPLoS ONE, 2012
In many organisms, homologous pairing and synapsis depend on the meiotic recombination machinery that repairs double-strand DNA breaks (DSBs) produced at the onset of meiosis.
Nohelia T Valenzuela   +2 more
doaj   +1 more source

Crossover interference mechanism: New lessons from plants

open access: yesFrontiers in Cell and Developmental Biology, 2023
Plants are the source of our understanding of several fundamental biological principles. It is well known that Gregor Mendel discovered the laws of Genetics in peas and that maize was used for the discovery of transposons by Barbara McClintock.
Nahid Rafiei, Arnaud Ronceret
doaj   +1 more source

Principles of meiotic chromosome assembly revealed in S. cerevisiae [PDF]

open access: yes, 2019
During meiotic prophase, chromosomes organise into a series of chromatin loops emanating from a proteinaceous axis, but the mechanisms of assembly remain unclear.
A Goloborodko   +69 more
core   +2 more sources

Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis. [PDF]

open access: yesPLoS Genetics, 2012
Meiotic recombination and chromosome synapsis between homologous chromosomes are essential for proper chromosome segregation at the first meiotic division. While recombination and synapsis, as well as checkpoints that monitor these two events, take place
Tomoyuki Fukuda   +5 more
doaj   +1 more source

Meiotic sex chromosome cohesion and autosomal synapsis are supported by Esco2.

open access: yes, 2020
In mitotic cells, establishment of sister chromatid cohesion requires acetylation of the cohesin subunit SMC3 (acSMC3) by ESCO1 and/or ESCO2. Meiotic cohesin plays additional but poorly understood roles in the formation of chromosome axial elements (AEs)
Biswas, U.   +6 more
core   +1 more source

UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells [PDF]

open access: yes, 2012
The N-end rule pathway is a proteolytic system in which its recognition components (N-recognins) recognize destabilizing N-terminal residues of short-lived proteins as an essential element of specific degrons, called N-degrons.
An, JY   +12 more
core   +1 more source

Cytotoxicity and Effects on the Synapsis Induced by Pure Cylindrospermopsin in an E17 Embryonic Murine Primary Neuronal Culture in a Concentration- and Time-Dependent Manner

open access: yesToxins, 2022
Cylindrospermopsin (CYN) is a cyanotoxin whose incidence has been increasing in the last decades. Due to its capacity to exert damage at different levels of the organism, it is considered a cytotoxin.
María G. Hinojosa   +6 more
doaj   +1 more source

Defending the genome from the enemy within:mechanisms of retrotransposon suppression in the mouse germline [PDF]

open access: yes, 2013
The viability of any species requires that the genome is kept stable as it is transmitted from generation to generation by the germ cells. One of the challenges to transgenerational genome stability is the potential mutagenic activity of transposable ...
A Aravin   +241 more
core   +2 more sources

Tau oligomers: the toxic player at synapses in Alzheimer’s disease

open access: yesFrontiers in Cellular Neuroscience, 2015
Alzheimer’s disease (AD) is a progressive disorder in which the most noticeable symptoms are cognitive impairment and memory loss. However, the precise mechanism by which those symptoms develop remains unknown.
Marcos Jair Guerrero-Munoz   +2 more
doaj   +1 more source

Chromosome Organization in Early Meiotic Prophase

open access: yesFrontiers in Cell and Developmental Biology, 2021
One of the most fascinating aspects of meiosis is the extensive reorganization of the genome at the prophase of the first meiotic division (prophase I). The first steps of this reorganization are observed with the establishment of an axis structure, that
Corinne Grey, Bernard de Massy
doaj   +1 more source

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