Meiotic sex chromosome cohesion and autosomal synapsis are supported by Esco2.
, 2020 In mitotic cells, establishment of sister chromatid cohesion requires acetylation of the cohesin subunit SMC3 (acSMC3) by ESCO1 and/or ESCO2. Meiotic cohesin plays additional but poorly understood roles in the formation of chromosome axial elements (AEs)
Biswas, U. +6 more
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A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs [PDF]
, 2019 Accurate meiotic chromosome segregation critically depends on the formation of inter-homolog crossovers initiated by double-strand breaks (DSBs). Inaccuracies in this process can drive aneuploidy and developmental defects, but how meiotic cells are ...
Aguilera López, Andrés +7 more
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Dynamics of rye chromosome 1R regions with high or low crossover frequency in homology search and synapsis development. [PDF]
PLoS ONE, 2012 In many organisms, homologous pairing and synapsis depend on the meiotic recombination machinery that repairs double-strand DNA breaks (DSBs) produced at the onset of meiosis.
Nohelia T Valenzuela +2 more
doaj +1 more source
A conserved filamentous assembly underlies the structure of the meiotic chromosome axis. [PDF]
, 2019 The meiotic chromosome axis plays key roles in meiotic chromosome organization and recombination, yet the underlying protein components of this structure are highly diverged.
Caballero, Iracema +10 more
core +4 more sources
Crossover interference mechanism: New lessons from plants
Frontiers in Cell and Developmental Biology, 2023 Plants are the source of our understanding of several fundamental biological principles. It is well known that Gregor Mendel discovered the laws of Genetics in peas and that maize was used for the discovery of transposons by Barbara McClintock.
Nahid Rafiei, Arnaud Ronceret
doaj +1 more source
UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells [PDF]
, 2012 The N-end rule pathway is a proteolytic system in which its recognition components (N-recognins) recognize destabilizing N-terminal residues of short-lived proteins as an essential element of specific degrons, called N-degrons.
An, JY +12 more
core +1 more source
Frontiers in Plant Science, 2017 The production of balanced fertile haploid gametes requires the faithful separation of paired (synapsed) chromosomes toward the end of meiotic prophase I (desynapsis).
Isabelle Colas +9 more
doaj +1 more source
Meiotic cohesin SMC1β provides prophase I centromeric cohesion and is required for multiple synapsis-associated functions. [PDF]
PLoS Genetics, 2013 Cohesin subunit SMC1β is specific and essential for meiosis. Previous studies showed functions of SMC1β in determining the axis-loop structure of synaptonemal complexes (SCs), in providing sister chromatid cohesion (SCC) in metaphase I and thereafter, in
Uddipta Biswas +6 more
doaj +1 more source
Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2. [PDF]
, 2017 The HORMA domain is a highly conserved protein-protein interaction module found in eukaryotic signaling proteins including the spindle assembly checkpoint protein Mad2 and the meiotic HORMAD proteins.
Corbett, Kevin D +2 more
core +2 more sources