Nanocatalytic Neuroprotection and Neurological Recovery Post‐Traumatic Brain Injury
This study demonstrates that combining Ce0.7Zr0.3O2 nanozymes with nimodipine enhances neuroprotection after traumatic brain injury. The therapy reduces oxidative stress, neuronal apoptosis, and improves blood–brain barrier integrity, with nanozymes effective at low doses.
Xinjie Hong+10 more
wiley +1 more source
Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission Ex Vivo. [PDF]
Mikaeloff F+32 more
europepmc +1 more source
Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics
Muralidharan and colleagues develop cell‐type‐specific transcriptomic aging clocks using single‐nucleus RNA sequencing of human post mortem prefrontal cortex samples. These clocks accurately predict age and identify distinct aging trajectories in specific brain cell types.
Chandramouli Muralidharan+12 more
wiley +1 more source
Parvalbumin interneuron impairment causes synaptic transmission deficits and seizures in SCN8A developmental and epileptic encephalopathy. [PDF]
Miralles RM+10 more
europepmc +1 more source
Endocannabinoid-mediated retrograde modulation of synaptic transmission
T. Ohno-Shosaku, M. Kano
semanticscholar +1 more source
Biohybrid Computing with Proteinoids and Algae
We developed a novel biohybrid computing system by combining proteinoid microspheres with algae. The biological mixture creates spontaneous electrical oscillations. These oscillations can perform simple logic operations, such as AND, OR, NAND, and NOR gates. Environmental factors like temperature and pH affect how the system works.
Panagiotis Mougkogiannis+1 more
wiley +1 more source
Paraventricular hypothalamic RUVBL2 neurons suppress appetite by enhancing excitatory synaptic transmission in distinct neurocircuits. [PDF]
Xing M+14 more
europepmc +1 more source
Capturing the Electrical Activity of all Cortical Neurons: Are Solutions Within Reach?
Despite advancements in implantable electrode technology, challenges persist in scaling up these devices to record most of the neuronal activity across the cortex. This review explores the limitations of both rigid and flexible probes, including tissue damage and foreign body response, while also discussing emerging biohybrid strategies.
Attila Kaszás+5 more
wiley +1 more source