Results 1 to 10 of about 109,698 (164)
Frontiers in Neuroscience, 2021 Selenium (Se) and its compounds have been reported to have great potential in the prevention and treatment of Alzheimer’s disease (AD). However, little is known about the functional mechanism of Se in these processes, limiting its further clinical ...
Zhong-Hao Zhang +4 more
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Food-derived Acetylcholinesterase Inhibitors as Potential Agents against Alzheimer’s Disease
eFood, 2021 Acetylcholinesterase (AChE) is a critical enzyme involved in nerve functions and signal transmission within the brain. However, during aging, excessive AChE activity often leads to rapid and progressive depletion of acetylcholine (ACh), the major ...
Rotimi E. Aluko
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eLife, 2023 We still face fundamental gaps in understanding how molecular plastic changes of synapses intersect with circuit operation to define behavioral states. Here, we show that an antagonism between two conserved regulatory proteins, Spinophilin (Spn) and Syd ...
Niraja Ramesh +6 more
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Cell Reports, 2013 Expression of the human Parkinson-disease-associated protein α-synuclein in all Drosophila neurons induces progressive locomotor deficits. Here, we identify a group of 15 dopaminergic neurons per hemisphere in the anterior medial region of the brain ...
Thomas Riemensperger +8 more
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Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis
eLife, 2020 Calcium (Ca2+)-evoked release of neurotransmitters from synaptic vesicles requires mechanisms both to prevent un-initiated fusion of vesicles (clamping) and to trigger fusion following Ca2+-influx. The principal components involved in these processes are
Sathish Ramakrishnan +4 more
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Phosphatidylserine, inflammation, and central nervous system diseases
Frontiers in Aging Neuroscience, 2022 Phosphatidylserine (PS) is an anionic phospholipid in the eukaryotic membrane and is abundant in the brain. Accumulated studies have revealed that PS is involved in the multiple functions of the brain, such as activation of membrane signaling pathways ...
Xiaohua Ma +7 more
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In VivoAdenovirus-Mediated Gene Transfer for Parkinson's Disease
Neurobiology of Disease, 1997 Gene therapy is a potentially powerful approach to the treatment of neurological diseases. Neurotransmitter synthesizing enzymes and neurotrophic factors inhibiting neurodegenerative processes provide the basis for current development of gene therapy ...
Philippe Horellou +2 more
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Dopamine drives Drosophila sechellia adaptation to its toxic host
eLife, 2014 Many insect species are host-obligate specialists. The evolutionary mechanism driving the adaptation of a species to a toxic host is, however, intriguing.
Sofía Lavista-Llanos +6 more
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Alzheimer’s Disease and Impaired Bone Microarchitecture, Regeneration and Potential Genetic Links
Life, 2023 Alzheimer’s Disease (AD) and osteoporosis are both age-related degenerative diseases. Many studies indicate that these two diseases share common pathogenesis mechanisms.
Min Zhang, Shunze Hu, Xuying Sun
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Adenovirus mediated gene transfer in organotypic brain slices
Neurobiology of Disease, 1995 A replication-defective adenovirus vector carrying the reporter gene encoding β-galactosidase was used to transfect organotypic slices maintained in culture for up to 1 month.
V. Ridoux +4 more
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