Results 251 to 260 of about 107,361 (347)

Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT 3 gene

, 1999
Toby B. Cole, H. Jürgen Wenzel, Kathy E. Kafer, Philip A. Schwartzkroin, Richard D. Palmiter   +4 more
openalex   +1 more source

Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu, Kyungdo Kim, Nicholas Asiimwe, Chan Hyun Na   +3 more
wiley   +1 more source

The exocytosis regulator complexin controls spontaneous synaptic vesicle release in a CAPS-dependent manner at C. elegans excitatory synapses. [PDF]

PLoS Biol
Wang Y, Chow CH, Zhang Y, Huang M, Higazy R, Ramakrishnan N, Chen L, Chen X, Deng Y, Wang S, Zhang C, Ma C, Sugita S, Gao S.   +13 more
europepmc   +1 more source

Memantine Administration Enhances Glutamatergic and GABAergic Pathways in the Human Hippocampus of Alzheimer's Disease Patients

PROTEOMICS, EarlyView.
ABSTRACT One of the traditional treatments in Alzheimer's disease (AD) is administration of memantine, the NMDA receptor antagonist. However, the molecular mechanism of the complex memantine action and the impact on the hippocampal proteome in humans is unknown.
Ivo Fabrik, Rudolf Kupcik, Daniela Fabrikova, Marketa Chvojkova, Kristina Holubova, Kristina Hakenova, Martin Horak, Jiri Soukup, Monika Manethova, Robert Rusina, Radoslav Matej, Ales Ryska, Ondrej Soukup   +12 more
wiley   +1 more source

Complexin regulation of synaptic vesicle release: mechanisms in the central nervous system and specialized retinal ribbon synapses. [PDF]

Cell Commun Signal
Li YZ, Wang Y, Jiao Q, Chi J, Liang Y, Fan B, Li GY.   +6 more
europepmc   +1 more source

Plasma Proteomic Profiling of a Group of Anxious Dogs by LC‐MS/MS: A Case–Control Study

PROTEOMICS – Clinical Applications, EarlyView.
ABSTRACT Purpose Anxiety is the most common underlying cause of behavioral problems in dogs, which remain a top reason for relinquishment and euthanasia. Despite its high prevalence, anxiety is often underdiagnosed, partly due to a limited understanding of biological processes and absence of diagnostic biomarkers.
Claudia Gaither, Robert Popp, Christoph H. Borchers, Francis Beaudry, Marion Desmarchelier   +4 more
wiley   +1 more source

Interactions of Therapeutic Antibodies With Presynaptically‐Released Misfolded Proteins in Neurodegenerative Diseases. A Spatial Monte‐Carlo Simulation Study

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT The spatial progression hypothesis of misfolded tau and alpha‐synuclein proteins in Alzheimer's and Parkinson's Disease proposes the release of proteins from a presynaptic membrane followed by diffusion over the synaptic cleft and uptake by the postsynaptic membrane in the afferent neuron.
Jamie Goff, Maryam Khalifa, Shaina M. Short, Piet H. van der Graaf, Hugo Geerts   +4 more
wiley   +1 more source

IL-1β promotes glutamate excitotoxicity: indications for the link between inflammatory and synaptic vesicle cycle in Ménière's disease. [PDF]

Cell Death Discov
Zhang N, Song Y, Wang H, Li X, Lyu Y, Liu J, Mu Y, Wang Y, Lu Y, Li G, Fan Z, Wang H, Zhang D, Li N.   +13 more
europepmc   +1 more source

Update on Gene Therapy in the Treatment of Hereditary Hearing Loss

Sensory Neuroscience, EarlyView.
Gene therapy is a promising therapeutic approach for genetic disorders, including three major gene therapy strategies: gene replacement, gene suppression, and gene editing. After transmitting genes to the inner ear through appropriate pathways, repair the cochlea in order to achieve the goal of treating hereditary hearing loss.
Weiwei He, Shanying Han, Xinghong Liu, Xiaotong Huang, Wen Yang, Xinghua Tang, Chuan Dong, Jiangang Fan   +7 more
wiley   +1 more source

Recognition of antiepileptic brivaracetam by synaptic vesicle protein 2A. [PDF]

Cell Discov
Liu S, Chao Y, Zhou Z, Yang C, Zhu Z, Wang Y, Qu Q.   +6 more
europepmc   +1 more source