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Synaptic Vesicle Phosphoproteins and Regulation of Synaptic Function
Science, 1993Complex brain functions, such as learning and memory, are believed to involve changes in the efficiency of communication between nerve cells. Therefore, the elucidation of the molecular mechanisms that regulate synaptic transmission, the process of intercellular communication, is an essential step toward understanding nervous system function.
GREENGARD P. +3 more
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Annual Review of Neuroscience, 2004
▪ Abstract Neurotransmitter release is mediated by exocytosis of synaptic vesicles at the presynaptic active zone of nerve terminals. To support rapid and repeated rounds of release, synaptic vesicles undergo a trafficking cycle. The focal point of the vesicle cycle is Ca2+-triggered exocytosis that is followed by different routes of endocytosis and ...
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▪ Abstract Neurotransmitter release is mediated by exocytosis of synaptic vesicles at the presynaptic active zone of nerve terminals. To support rapid and repeated rounds of release, synaptic vesicles undergo a trafficking cycle. The focal point of the vesicle cycle is Ca2+-triggered exocytosis that is followed by different routes of endocytosis and ...
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Synaptic vesicle life cycle and synaptic turnover
Journal of Physiology-Paris, 1993Cholinergic synaptic vesicles contain a mixture of soluble low molecular mass constituents. Besides acetylcholine these include Ca2+, ATP, GTP, small amounts of ADP and AMP, and also the diadenosine polyphosphates Ap4A and Ap5A. In synaptic vesicles isolated from the electric ray these diadenosine polyphosphates occur in mmol concentrations and might ...
H, Zimmermann +3 more
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On synaptic vesicles, complex vesicles and dense projections
Brain Research, 1970Observations support the view that in vertebrates synaptic vesicles are produced by liberation from complex vesicles, which in turn are derived from the membranes of the presynaptic bag. Some of the shell fragments of the complex vesicles remain in the bag, whereas other fragments of the shell adhere to the wall of the synaptic vesicle. It is suggested
E G, Gray, R A, Willis
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ELECTROPHYSIOLOGY OF SYNAPTIC VESICLE CYCLING
Annual Review of Physiology, 1999▪ Abstract Patch-clamp capacitance measurements can monitor in real time the kinetics of exocytosis and endocytosis in living cells. We review the application of this technique to the giant presynaptic terminals of goldfish bipolar cells. These terminals secrete glutamate via the fusion of small, clear-core vesicles at specialized, active zones of ...
H, von Gersdorff, G, Matthews
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Mechanisms of Synaptic Vesicle Exocytosis
Annual Review of Cell and Developmental Biology, 2000▪ Abstract Chemical synaptic transmission serves as the main form of cell to cell communication in the nervous system. Neurotransmitter release occurs through the process of regulated exocytosis, in which a synaptic vesicle releases its contents in response to an increase in calcium.
R C, Lin, R H, Scheller
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Synapsins and Synaptic Vesicle Storage
2014The synapsins constitute a family of evolutionarily conserved neuronal phosphoproteins associated with the cytosolic surface of synaptic vesicles. In mammals, the family comprises three members encoded by distinct genes that give rise to various splicing isoforms.
Guarnieri F. C. +2 more
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The transport of neurotransmitters into synaptic vesicles
Current Opinion in Neurobiology, 1992As investigations identify additional plasma membrane neurotransmitter transporters, attention has focused on the molecular basis of neurotransmitter transport into synaptic vesicles. The transport of biogenic amines into chromaffin granules has served as the paradigm for understanding vesicular transport.
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SYNAPTIC VESICLE HETEROGENEITY
Journal of Neurochemistry, 1984R M, Marchbanks +2 more
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The synaptic vesicle and its targets
Neuroscience, 1995Synaptic vesicles play the central role in synaptic transmission. They are regarded as key organelles involved in synaptic functions such as uptake, storage and stimulus-dependent release of neurotransmitter. In the last few years our knowledge concerning the molecular components involved in the functioning of synaptic vesicles has grown impressively ...
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