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Isolation of Synaptic Vesicles

Current Protocols in Cell Biology, 2004
AbstractSynaptic vesicles are the most abundant secretory organelle in eukaryotic neural cells. Synaptic vesicles are physically distinct from other membrane‐bound organelles because they are small, spherical, and highly uniform in size with a diameter of about 40 nm.
Branch, Craige   +2 more
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Biogenesis of synaptic vesicles

Journal of Cell Science, 1993
ABSTRACT The basic endosomal recycling pathway can be modified to generate transcytotic vesicles, storage vesicles and synaptic vesicles. Sorting into synaptic vesicles requires specialized sorting information not present in the transcytotic and storage vesicle proteins.
R B, Kelly   +5 more
openaire   +2 more sources

THE SYNAPTIC VESICLE CYCLE

Annual Review of Physiology, 1998
▪ Abstract  The ins and outs of the synaptic vesicle cycle are being examined in increasing detail with diverse investigative tools in a variety of cell types, particularly those with large granules. The cycle begins with the opening of a fusion pore that connects the vesicle lumen to the extracellular fluid.
W J, Betz, J K, Angleson
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Synaptic Vesicles and Exocytosis

Annual Review of Neuroscience, 1994
Neurons transmit information by releasing neurotransmitters from presynaptic nerve endings, In the resting stage , transmitters are stored in small organelles of uniform size and shape , the synaptic vesicles . When an action potential arrives in the nerve terminal , the membrane depolarizes and voltage-gated Ca2+ channels open .
R, Jahn, T C, Südhof
openaire   +2 more sources

In vivo evidence of lower synaptic vesicle density in schizophrenia

Molecular Psychiatry, 2021
Rajiv Radhakrishnan   +11 more
semanticscholar   +1 more source

Synaptic vesicle life cycle and synaptic turnover

Journal of Physiology-Paris, 1993
Cholinergic synaptic vesicles contain a mixture of soluble low molecular mass constituents. Besides acetylcholine these include Ca2+, ATP, GTP, small amounts of ADP and AMP, and also the diadenosine polyphosphates Ap4A and Ap5A. In synaptic vesicles isolated from the electric ray these diadenosine polyphosphates occur in mmol concentrations and might ...
H, Zimmermann   +3 more
openaire   +2 more sources

Exocytosis and Synaptic Vesicle Function

Comprehensive Physiology, 2014
Synaptic vesicles release their vesicular contents to the extracellular space by Ca2+‐triggered exocytosis. The Ca2+‐triggered exocytotic process is regulated by synaptotagmin (Syt), a vesicular Ca2+‐binding C2 domain protein. Synaptotagmin 1 (Syt1), the
O. Shin
semanticscholar   +1 more source

The Synaptic Vesicle

1984
Synaptic vesicles are the characteristic organelles of the presynaptic nerve terminals of chemical synapses (i.e., those utilizing the release of a specific chemical transmitter substance to bring about synaptic transmission). They are normally 45–50 nm in diameter and must be among the most homogeneous and uniform lipoprotein membrane organelles known.
openaire   +2 more sources

SYNAPTIC VESICLE HETEROGENEITY

Journal of Neurochemistry, 1984
R M, Marchbanks   +2 more
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Synaptic Vesicle Endocytosis

2008
Synapses locally recycle vesicles to ensure the maintenance of neuronal communication critical for normal brain function. While several modes of vesicle regeneration are thought to exist, clathrin-mediated endocytosis (CME) is the best studied mechanism of synaptic vesicle recycling.
Liesbet Smitz, Patrik Verstreken
openaire   +1 more source

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