Results 101 to 110 of about 6,353,452 (269)
PLoS Genetics, 2019 The ubiquitin proteasome system regulates meiotic recombination in yeast through its association with the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I.
Laura Gómez-H +11 more
doaj +1 more source
Full-length synaptonemal complex grows continuously during meiotic prophase in budding yeast. [PDF]
PLoS Genetics, 2012 the synaptonemal complex (SC) links two meiotic prophase chromosomal events: homolog pairing and crossover recombination. SC formation involves the multimeric assembly of coiled-coil proteins (Zip1 in budding yeast) at the interface of aligned homologous
Karen Voelkel-Meiman +4 more
doaj +1 more source
eLife, 2017 The synaptonemal complex (SC) is a polymer that spans ~100 nm between paired homologous chromosomes during meiosis. Its striated, periodic appearance in electron micrographs led to the idea that transverse filaments within this structure ‘crosslink’ the ...
O. Rog, S. Köhler, A. Dernburg
semanticscholar +1 more source
Protein-protein interactions in the synaptonemal complex. [PDF]
Molecular Biology of the Cell, 1997 In mammalian systems, an approximately M(r) 30,000 Cor1 protein has been identified as a major component of the meiotic prophase chromosome cores, and a M(r) 125,000 Syn1 protein is present between homologue cores where they are synapsed and form the synaptonemal complex (SC). Immunolocalization of these proteins during meiosis suggests possible homo-
M S Park +4 more
openaire +3 more sources
Long non‐coding RNAs as key regulators of neurodegenerative protein aggregation
Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.Abstract The characteristic events in neurodegenerative diseases (NDDs) encompass protein misfolding, aggregation, accumulation, and their related cellular dysfunction, synaptic function loss. While distinct proteins are implicated in the pathological processes of different NDDs, the process of protein misfolding and aggregation remains notably similar
Qi Xu +4 more
wiley +1 more source
Frontiers in Plant Science, 2018 The repair of SPO11-dependent double-strand breaks (DSBs) by homologous recombination (HR) ensures the correct segregation of homologous chromosomes. In yeast and human, RAD17 is involved in DNA damage checkpoint control and DSB repair.
Qing Hu +10 more
doaj +1 more source
Synaptonemal complex protein 3 is a prognostic marker in cervical cancer. [PDF]
PLoS ONE, 2014 Synaptonemal complex protein 3 (SCP3), a member of Cor1 family, is up-regulated in various cancer cells; however, its oncogenic potential and clinical significance has not yet been characterized.
Hanbyoul Cho +8 more
doaj +1 more source
Dynamic reorganization of the genome shapes the recombination landscape in meiotic prophase. [PDF]
, 2019 In meiotic prophase, chromosomes are organized into compacted loop arrays to promote homolog pairing and recombination. Here, we probe the architecture of the mouse spermatocyte genome in early and late meiotic prophase using chromosome conformation ...
Chee, Sora +9 more
core +1 more source
Frontiers in Plant Science, 2019 During prophase I a meiosis-specific proteinaceous tripartite structure, the synaptonemal complex (SC), forms a scaffold to connect homologous chromosomes along their lengths.
Susann Hesse +5 more
semanticscholar +1 more source
Inactivation of JNK signalling results in polarity loss and cell senescence of Sertoli cell
Cell Proliferation, Volume 58, Issue 2, February 2025.JNK signalling plays a critical role in Sertoli cells development and functional maintenance. Disruption of JNK signalling leads to polarity loss and cell senescence in Sertoli cells, resulting in aberrant testis development and male infertility in mouse models.
Zhiming Shen +12 more
wiley +1 more source