A conserved filamentous assembly underlies the structure of the meiotic chromosome axis. [PDF]
, 2019 The meiotic chromosome axis plays key roles in meiotic chromosome organization and recombination, yet the underlying protein components of this structure are highly diverged.
Caballero, Iracema +10 more
core +4 more sources
Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2. [PDF]
, 2017 The HORMA domain is a highly conserved protein-protein interaction module found in eukaryotic signaling proteins including the spindle assembly checkpoint protein Mad2 and the meiotic HORMAD proteins.
Corbett, Kevin D +2 more
core +2 more sources
Synaptonemal complex karyotype of zebrafish [PDF]
Heredity, 2003 Meiotic cells of zebrafish have been prepared to show synaptonemal complexes (SCs) by light and electron microscopy. Completely paired SCs from both spermatocytes and oocytes were measured to produce an SC karyotype. The SC karyotype resembles the somatic karyotype of zebrafish and has no recognisable sex bivalent.
B M N, Wallace, H, Wallace
openaire +2 more sources
PLoS Genetics, 2009 In mammals, the synaptonemal complex is a structure required to complete crossover recombination. Although suggested by cytological work, in vivo links between the structural proteins of the synaptonemal complex and the proteins of the recombination ...
Ewelina Bolcun-Filas +7 more
doaj +1 more source
Hexavalents in spermatocytes of Robertsonian heterozygotes between Mus m. domesticus 2n 26 from the Vulcano and Lipari Islands (Aeolian Archipelago, Italy) [PDF]
, 2018 The size and shape of the chromosomes, as well as the chromosomal domains that compose them, are determinants in the distribution and interaction between the bivalents within the nucleus of spermatocytes in prophase I of meiosis.
Eliana Ayarza +6 more
core +3 more sources
A new role for the synaptonemal complex in the regulation of meiotic recombination. [PDF]
Genes Dev, 2020 This Outlook discusses Mu et al.’s finding showing that synaptonemal complex (SC) formation between individual chromosomes provides the feedback to down-regulate Spo11 activity, thereby revealing an additional function for the SC.
Hollingsworth NM.
europepmc +2 more sources
Apoptosis in mouse fetal and neonatal oocytes during meiotic prophase one [PDF]
, 2007 Background The vast majority of oocytes formed in the fetal ovary do not survive beyond birth. Possible reasons for their loss include the elimination of non-viable genetic constitutions arising through meiosis, however, the ...
Ghafari , Fataneh +2 more
core +4 more sources
C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility
Nature Communications, 2016 The synaptonemal complex is a meiosis-specific proteinaceous structure that supports homologous chromosome pairs during meiosis. Here, the authors show that SIX6OS1 (of previously unknown function) is part of the synaptonemal complex central element and ...
Laura Gómez-H +12 more
doaj +1 more source
A molecular cell biology toolkit for the study of meiosis in the silkworm Bombyx mori
G3: Genes, Genomes, Genetics, 2023 Meiosis is usually described as 4 essential and sequential processes: (1) homolog pairing; (2) synapsis, mediated by the synaptonemal complex; (3) crossing over; and (4) segregation.
Youbin Xiang +9 more
doaj +1 more source
Multivalent weak interactions between assembly units drive synaptonemal complex formation
Journal of Cell Biology, 2020 Zhang et al. identify new synaptonemal complex (SC) central region proteins SYP-5 and SYP-6 in Caenorhabditis elegans and show that SC central region proteins form assembly units through stable interactions and weak interactions between the units that ...
Zhenguo Zhang +15 more
semanticscholar +1 more source