Synaptonemal complex components persist at centromeres and are required for homologous centromere pairing in mouse spermatocytes. [PDF]
PLoS Genetics, 2012 Recent studies in simple model organisms have shown that centromere pairing is important for ensuring high-fidelity meiotic chromosome segregation. However, this process and the mechanisms regulating it in higher eukaryotes are unknown.
C Gaston Bisig +6 more
doaj +1 more source
A new role for the synaptonemal complex in the regulation of meiotic recombination. [PDF]
Genes Dev, 2020 This Outlook discusses Mu et al.’s finding showing that synaptonemal complex (SC) formation between individual chromosomes provides the feedback to down-regulate Spo11 activity, thereby revealing an additional function for the SC.
Hollingsworth NM.
europepmc +2 more sources
A role for synaptonemal complex in meiotic mismatch repair. [PDF]
Genetics, 2022 AbstractDuring meiosis a large subset of interhomolog recombination repair intermediates form within the physical context of the synaptonemal complex (SC), a protein-rich structure assembled at the interface of aligned homologous chromosomes. However, the functional relationship between SC structure and homologous recombination remains poorly defined ...
Voelkel-Meiman K +5 more
europepmc +5 more sources
Sex in Symbiodiniaceae dinoflagellates: genomic evidence for independent loss of the canonical synaptonemal complex. [PDF]
Sci Rep, 2020 Dinoflagellates of the Symbiodiniaceae family encompass diverse symbionts that are critical to corals and other species living in coral reefs. It is well known that sexual reproduction enhances adaptive evolution in changing environments.
Shah S, Chen Y, Bhattacharya D, Chan CX.
europepmc +2 more sources
The synaptonemal complex aligns meiotic chromosomes by wetting. [PDF]
Sci AdvAbstractDuring meiosis, the parental chromosomes are drawn together to enable exchange of genetic information. Chromosomes are aligned through the assembly of a conserved interface, the synaptonemal complex, composed of a central region that forms between two parallel chromosomal backbones called axes. Here we identify the axis-central region interface
Gordon SG +5 more
europepmc +5 more sources
Synaptonemal Complexities and Commonalities [PDF]
Molecular Cell, 2003 Formation of synaptonemal complex and high levels of homologous recombination are the hallmarks of meiotic prophase. The relationship between these two processes has been the subject of intense study for nearly 50 years. Recent findings highlight the differences and commonalities of this relationship in different species.
openaire +3 more sources
Tracking down the molecular architecture of the synaptonemal complex by expansion microscopy. [PDF]
Nat Commun, 2020 The synaptonemal complex (SC) is a meiosis-specific nuclear multiprotein complex that is essential for proper synapsis, recombination and segregation of homologous chromosomes. We combined structured illumination microscopy (SIM) with different expansion
Zwettler FU +6 more
europepmc +2 more sources
Multivalent weak interactions between assembly units drive synaptonemal complex formation
Journal of Cell Biology, 2020 Zhang et al. identify new synaptonemal complex (SC) central region proteins SYP-5 and SYP-6 in Caenorhabditis elegans and show that SC central region proteins form assembly units through stable interactions and weak interactions between the units that ...
Zhenguo Zhang +15 more
semanticscholar +1 more source
A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs [PDF]
, 2019 Accurate meiotic chromosome segregation critically depends on the formation of inter-homolog crossovers initiated by double-strand breaks (DSBs). Inaccuracies in this process can drive aneuploidy and developmental defects, but how meiotic cells are ...
Aguilera López, Andrés +7 more
core +1 more source
Meiotic recombination proteins localize to linear elements in Schizosaccharomyces pombe [PDF]
, 2006 Peer ...
Estreicher, A. +3 more
core +1 more source