Results 51 to 60 of about 284,832 (240)

The use of deidentified organ donor testes for research

Andrology, EarlyView.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova, Marnie W. Skinner, Juliana I. Candelaria, Stephen R. Wellard, Philip W. Jordan   +4 more
wiley   +1 more source

Full-length synaptonemal complex grows continuously during meiotic prophase in budding yeast. [PDF]

PLoS Genetics, 2012
the synaptonemal complex (SC) links two meiotic prophase chromosomal events: homolog pairing and crossover recombination. SC formation involves the multimeric assembly of coiled-coil proteins (Zip1 in budding yeast) at the interface of aligned homologous
Karen Voelkel-Meiman, Sarah S Moustafa, Philippe Lefrançois, Anne M Villeneuve, Amy J MacQueen   +4 more
doaj   +1 more source

Testis‐Specific PDHA2 Is Required for Proper Meiotic Recombination and Chromosome Organisation During Spermatogenesis

Cell Proliferation, EarlyView.
PDHA2, a testis‐specific subunit of pyruvate dehydrogenase, is required for the conversion of pyruvate to acetyl‐CoA. Its absence results in decreased acetyl‐CoA and precursors for metabolites and energy during spermatogenesis. This results in decreased histone acetylation, defective chromosome structure and moderately reduced crossovers, ultimately ...
Guoqiang Wang, Kailun Fang, Yongliang Shang, Xu Zhou, Qiqi Shao, Si Li, Ping Wang, Charlie Degui Chen, Liangran Zhang, Shunxin Wang   +9 more
wiley   +1 more source

An example of a domain in a complex flag manifold [PDF]

arXiv, 2022
This paper shows an example of a connected open neighborhood of a compact connected complex submanifold in a complex flag manifold.
arxiv  

Identification and Characterization of Novel FSHR Copy Number Variations Causing Premature Ovarian Insufficiency

American Journal of Medical Genetics Part A, Volume 197, Issue 3, March 2025.
ABSTRACT Follicle stimulating hormone (FSH) is a key pituitary gonadotropic hormone implicated in human fertility and is crucial for folliculogenesis and recruitment of new antral follicles. Variations in its receptor, FSHR, can lead to diverse reproductive phenotypes including ovarian hyperstimulation syndrome (OHSS) and premature ovarian ...
Anna Lokchine, Anne Bergougnoux, Nadège Servant, Linda Akloul, Erika Launay, Laura Mary, Laurence Cluzeau, Mathieu Philippe, Mathilde Domin‐Bernhard, Solène Duros, Sylvie Odent, Elena Tucker, Françoise Paris, Marc‐Antoine Belaud‐Rotureau, Sylvie Jaillard   +14 more
wiley   +1 more source

Meiotic crossovers revealed by differential visualization of homologous chromosomes using enhanced haplotype oligo‐painting in cucumber

Plant Biotechnology Journal, Volume 23, Issue 3, Page 887-899, March 2025.
Summary The interaction dynamics of homologous chromosomes during meiosis, such as recognition, pairing, synapsis, recombination, and segregation are vital for species fertility and genetic diversity within populations. Meiotic crossover (CO), a prominent feature of meiosis, ensures the faithful segregation of homologous chromosomes and enriches ...
Qinzheng Zhao, Zhenhui Xiong, Chunyan Cheng, Yuhui Wang, Xianbo Feng, Xiaqing Yu, Qunfeng Lou, Jinfeng Chen   +7 more
wiley   +1 more source

Synaptonemal complex antigen location and conservation. [PDF]

The Journal of cell biology, 1987
The axial cores of chromosomes in the meiotic prophase nuclei of most sexually reproducing organisms play a pivotal role in the arrangement of chromatin, in the synapsis of homologous chromosomes, in the process of genetic recombination, and in the disjunction of chromosomes.
A.J.J. Dietrich, W. van Raamsdonk, Q Chen, Peter B. Moens, Christa Heyting   +4 more
openaire   +3 more sources

Long non‐coding RNAs as key regulators of neurodegenerative protein aggregation

Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.
Abstract The characteristic events in neurodegenerative diseases (NDDs) encompass protein misfolding, aggregation, accumulation, and their related cellular dysfunction, synaptic function loss. While distinct proteins are implicated in the pathological processes of different NDDs, the process of protein misfolding and aggregation remains notably similar
Qi Xu, Dan Liu, Ling‐Qiang Zhu, Ying Su, He‐Zhou Huang   +4 more
wiley   +1 more source

The PSMA8 subunit of the spermatoproteasome is essential for proper meiotic exit and mouse fertility.

PLoS Genetics, 2019
The ubiquitin proteasome system regulates meiotic recombination in yeast through its association with the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I.
Laura Gómez-H, Natalia Felipe-Medina, Yazmine B Condezo, Rodrigo Garcia-Valiente, Isabel Ramos, José Angel Suja, José Luis Barbero, Ignasi Roig, Manuel Sánchez-Martín, Dirk G de Rooij, Elena Llano, Alberto M Pendas   +11 more
doaj   +1 more source

Inactivation of JNK signalling results in polarity loss and cell senescence of Sertoli cell

Cell Proliferation, Volume 58, Issue 2, February 2025.
JNK signalling plays a critical role in Sertoli cells development and functional maintenance. Disruption of JNK signalling leads to polarity loss and cell senescence in Sertoli cells, resulting in aberrant testis development and male infertility in mouse models.
Zhiming Shen, Yang Gao, Xuedong Sun, Min Chen, Changhuo Cen, Mengyue Wang, Nan Wang, Bowen Liu, Jiayi Li, Xiuhong Cui, Jian Hou, Yuhua Shi, Fei Gao   +12 more
wiley   +1 more source