Results 51 to 60 of about 6,519,238 (204)

Coiled-coil structure of meiosis protein TEX12 and conformational regulation by its C-terminal tip

Communications Biology, 2022
The X-ray crystal structures of C-terminal mutants of the coiled-coil protein cancer testis antigen TEX12 in combination with modeling of the TEX12 wild-type dimer reveal the protein’s control of its oligomeric state, which resembles assembly of its ...
James M. Dunce, Lucy J. Salmon, Owen R. Davies   +2 more
doaj   +1 more source

A conserved filamentous assembly underlies the structure of the meiotic chromosome axis. [PDF]

, 2019
The meiotic chromosome axis plays key roles in meiotic chromosome organization and recombination, yet the underlying protein components of this structure are highly diverged.
Caballero, Iracema, Corbett, Kevin D, Hagemann, Götz, Herzog, Franz, Lehmer, Madison K, MacQueen, Amy J, Rosenberg, Scott C, Ur, Sarah N, Usón, Isabel, West, Alan Mv, Ye, Qiaozhen   +10 more
core   +4 more sources

Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2. [PDF]

, 2017
The HORMA domain is a highly conserved protein-protein interaction module found in eukaryotic signaling proteins including the spindle assembly checkpoint protein Mad2 and the meiotic HORMAD proteins.
Corbett, Kevin D, Komives, Elizabeth A, West, Alan MV   +2 more
core   +2 more sources

Mutation of the mouse Syce1 gene disrupts synapsis and suggests a link between synaptonemal complex structural components and DNA repair.

PLoS Genetics, 2009
In mammals, the synaptonemal complex is a structure required to complete crossover recombination. Although suggested by cytological work, in vivo links between the structural proteins of the synaptonemal complex and the proteins of the recombination ...
Ewelina Bolcun-Filas, Emma Hall, Robert Speed, Mary Taggart, Corinne Grey, Bernard de Massy, Ricardo Benavente, Howard J Cooke   +7 more
doaj   +1 more source

A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs [PDF]

, 2019
Accurate meiotic chromosome segregation critically depends on the formation of inter-homolog crossovers initiated by double-strand breaks (DSBs). Inaccuracies in this process can drive aneuploidy and developmental defects, but how meiotic cells are ...
Aguilera López, Andrés, Boulton, Simon J., Galindo Díaz, U., García Muse, Tatiana, García Rubio, María Luisa, Martin, Julie S., O'Reilly, N., Polanowska, Jolanta   +7 more
core   +1 more source

A molecular cell biology toolkit for the study of meiosis in the silkworm Bombyx mori

G3: Genes, Genomes, Genetics, 2023
Meiosis is usually described as 4 essential and sequential processes: (1) homolog pairing; (2) synapsis, mediated by the synaptonemal complex; (3) crossing over; and (4) segregation.
Youbin Xiang, Dai Tsuchiya, Fengli Guo, Jennifer Gardner, Scott McCroskey, Andrew Price, Eelco C Tromer, James R Walters, Cathleen M Lake, R Scott Hawley   +9 more
doaj   +1 more source

Multivalent weak interactions between assembly units drive synaptonemal complex formation

Journal of Cell Biology, 2020
Zhang et al. identify new synaptonemal complex (SC) central region proteins SYP-5 and SYP-6 in Caenorhabditis elegans and show that SC central region proteins form assembly units through stable interactions and weak interactions between the units that ...
Zhenguo Zhang, Songbo Xie, Ruoxi Wang, Shuqun Guo, Qiuchen Zhao, Hui Nie, Yuanyuan Liu, Fengguo Zhang, Miao Chen, Libo Liu, Xiaoqian Meng, Min Liu, Li Zhao, M. Colaiácovo, Jun Zhou, Jinmin Gao   +15 more
semanticscholar   +1 more source

Hexavalents in spermatocytes of Robertsonian heterozygotes between Mus m. domesticus 2n 26 from the Vulcano and Lipari Islands (Aeolian Archipelago, Italy) [PDF]

, 2018
The size and shape of the chromosomes, as well as the chromosomal domains that compose them, are determinants in the distribution and interaction between the bivalents within the nucleus of spermatocytes in prophase I of meiosis.
Eliana Ayarza, Emanuela Solano, Ernesto Capanna, Jesús Page, Raúl Fernández-Donoso, Riccardo Castiglia, Soledad Berríos   +6 more
core   +3 more sources

Essential and checkpoint functions of budding yeast ATM and ATR during meiotic prophase are facilitated by differential phosphorylation of a meiotic adaptor protein, Hop1 [PDF]

, 2015
A hallmark of the conserved ATM/ATR signalling is its ability to mediate a wide range of functions utilizing only a limited number of adaptors and effector kinases.
A Alcasabas, A Emili, A Traven, AA Ali, Alastair S. Goldman, Ana Penedos, Anthony L. Johnson, B Argunhan, C Chuang, D Bishop, D Durocher, D Durocher, D Lydall, D Ontoso, D Woltering, DK Bishop, Emily Strong, H Cartagena-Lirola, H Lee, H Niu, H Niu, H Tsubouchi, HY Wu, I Acosta, J Falk, J Harper, J Melo, JA Carballo, JA Carballo, JA Carballo, Jesús A. Carballo, JM Bailis, JP Lao, K Hofmann, L Wan, L Xu, M Shinohara, MB Yaffe, Michael Lichten, NM Hollingsworth, NM Hollingsworth, R Suhandynata, Rita S. Cha, RS Cha, S Gray, T Allers, T de los Santos, T Tougan, T Usui, V Busygina, Y Sanchez, YH Lo   +51 more
core   +11 more sources

A BIRD´S-EYE VIEW OF CHROMOSOMES DURING MEIOTIC PROPHASE I [PDF]

BAG. Journal of Basic and Applied Genetics, 2022
The present review aims to summarize the research carried out in relation to meiosis in birds, especially by observing the protein axes of the chromosomes in prophase I of meiosis. This line of research, initially developed in Argentina, has provided key
Pigozzi M.I.
doaj   +1 more source