Results 61 to 70 of about 6,519,238 (204)

Dynamic molecular architecture of the synaptonemal complex

bioRxiv, 2020
During meiosis, pairing between homologous chromosomes is stabilized by the assembly of a protein lattice known as the synaptonemal complex (SC).
S. Köhler, Michal Wójcik, Ke Xu, A. Dernburg   +3 more
semanticscholar   +1 more source

Principles of meiotic chromosome assembly revealed in S. cerevisiae [PDF]

, 2019
During meiotic prophase, chromosomes organise into a series of chromatin loops emanating from a proteinaceous axis, but the mechanisms of assembly remain unclear.
A Goloborodko, A Hayashi, A Lengronne, A Storlazzi, A Tedeschi, AL Sanborn, AV Smith, B Bonev, D Thacker, D Zickler, E Alipour, E Crane, E Trelles-Sticken, EF Glynn, EP Nora, EP Nora, F Klein, G Fudenberg, G Fudenberg, G Fudenberg, G Wutz, GA Busslinger, H Jin, H Muller, H Tjong, H Wong, J Dekker, J Dekker, J Gassler, J Li, JA Carballo, JF Marko, JHI Haarhuis, JM Belton, JR Dixon, K Challa, K Nasmyth, KG Alavattam, L Lazar-Stefanita, L Patel, L Xu, M Ito, M Merkenschlager, M Sym, M Sym, MN Conrad, N Naumova, N Servant, NJ Petela, NM Hollingsworth, O Crawley, P Eastman, P Eastman, P Kerpedjiev, PB Møens, Q Jin, S Heinz, S Maleki, S Panizza, SA Schalbetter, SSP Rao, SSP Rao, T Mizuguchi, T Sakuno, TS Hsieh, VV Subramanian, W Schwarzer, Y Blat, Y Kakui, Y Wang   +69 more
core   +2 more sources

Meiotic sex chromosome cohesion and autosomal synapsis are supported by Esco2.

, 2020
In mitotic cells, establishment of sister chromatid cohesion requires acetylation of the cohesin subunit SMC3 (acSMC3) by ESCO1 and/or ESCO2. Meiotic cohesin plays additional but poorly understood roles in the formation of chromosome axial elements (AEs)
Biswas, U., Eichele, G., Hempel, K., Jessberger, R., Kühnel, A., McNicoll, F., Whelan, G.   +6 more
core   +1 more source

Apoptosis in mouse fetal and neonatal oocytes during meiotic prophase one [PDF]

, 2007
Background The vast majority of oocytes formed in the fetal ovary do not survive beyond birth. Possible reasons for their loss include the elimination of non-viable genetic constitutions arising through meiosis, however, the ...
Ghafari , Fataneh, Gutierrez , Carlos G., Hartshorne, Geraldine M.   +2 more
core   +4 more sources

The synaptonemal complex central region modulates crossover pathways and feedback control of meiotic double-strand break formation

bioRxiv, 2020
The synaptonemal complex (SC) is a proteinaceous structure that mediates homolog engagement and genetic recombination during meiosis. Zip-Mer-Msh (ZMM) proteins promote crossover (CO) formation and initiate SC formation.
Min-Su Lee, Mika T. Higashide, HyungSeok Choi, Ke Li, Soogil Hong, Kangseok Lee, A. Shinohara, M. Shinohara, K. Kim   +8 more
semanticscholar   +1 more source

Crystal structure of Hop2-Mnd1 and mechanistic insights into its role in meiotic recombination [PDF]

, 2015
In meiotic DNA recombination, the Hop2-Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex by a yet-unclear mechanism.
Alexandra-Styliani Kalantzi, Bergerat, Bishop, Brown, Brunger, Bugreev, Byung-Ha Oh, Case, Chan, Chen, Chi, Cho, Christopher P. Toseland, Cloud, de Massy, De Vlaminck, de Vries, Emsley, Enomoto, Ferrari, Garcia, Haruta, Hayase, Ho-Chul Shin, Holm, Hyun-Ah Kang, Hyun-Min Kim, Keeney, Keeney, Kokabu, Kuwabara, Lange, Leu, Lu, Lu, Lu, Matteo Dal Peraro, Moktan, Morrison, Neale, Okorokov, Otwinowski, Pettersen, Petukhova, Petukhova, Pezza, Pezza, Phillips, Ploquin, Qiao, Rabitsch, Roeder, Rothenberg, Say, Schwacha, Sheridan, Sheridan, Soding, Stephan Gruber, Terwilliger, Tsai, Tsubouchi, Tsubouchi, Uanschou, van der Heijden, Wright, Zhao   +66 more
core   +3 more sources

Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling

Molecular Systems Biology, 2013
Genes with common profiles of the presence and absence in disparate genomes tend to function in the same pathway. By mapping all human genes into about 1000 clusters of genes with similar patterns of conservation across eukaryotic phylogeny, we ...
Yuval Tabach, Tamar Golan, Abrahan Hernández‐Hernández, Arielle R Messer, Tomoyuki Fukuda, Anna Kouznetsova, Jian‐Guo Liu, Ingrid Lilienthal, Carmit Levy, Gary Ruvkun   +9 more
doaj   +1 more source

How to halve ploidy : lessons from budding yeast meiosis [PDF]

, 2012
Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells.
Arumugam, Prakash, Kerr, Gary W., Sarkar, Sourav   +2 more
core   +1 more source

Surveillance of cohesin-supported chromosome structure controls meiotic progression

Nature Communications, 2020
Meiosis-specific cohesins and the synaptonemal complex are essential for meiotic chromosome structure and function. Here the authors show that continued surveillance of these chromosome structures controls meiotic progression by regulating CHK-2, a ...
Maikel Castellano-Pozo, Sarai Pacheco, Georgios Sioutas, Angel Luis Jaso-Tamame, Marian H. Dore, Mohammad M. Karimi, Enrique Martinez-Perez   +6 more
doaj   +1 more source

Synaptonemal complex components promote centromere pairing in pre-meiotic germ cells. [PDF]

PLoS Genetics, 2013
Mitosis and meiosis are two distinct cell division programs. During mitosis, sister chromatids separate, whereas during the first meiotic division, homologous chromosomes pair and then segregate from each other.
Nicolas Christophorou, Thomas Rubin, Jean-René Huynh   +2 more
doaj   +1 more source