Results 61 to 70 of about 6,599,798 (249)

Identification of novel synaptonemal complex components in C. elegans

Journal of Cell Biology, 2020
The synaptonemal complex (SC) is a zipper-like protein structure that forms between paired homologous chromosomes during meiosis. Hurlock et al. discover two novel SC components, SYP-5 and SYP-6, in C.
Matthew E. Hurlock, Ivana Čavka, Lisa E. Kursel, Jocelyn Haversat, Matthew Wooten, Z. Nizami, Rashi Turniansky, P. Hoess, J. Ries, J. Gall, O. Rog, S. Köhler, Yumi Kim   +12 more
semanticscholar   +1 more source

A BIRD´S-EYE VIEW OF CHROMOSOMES DURING MEIOTIC PROPHASE I [PDF]

BAG. Journal of Basic and Applied Genetics, 2022
The present review aims to summarize the research carried out in relation to meiosis in birds, especially by observing the protein axes of the chromosomes in prophase I of meiosis. This line of research, initially developed in Argentina, has provided key
Pigozzi M.I.
doaj   +1 more source

Principles of meiotic chromosome assembly revealed in S. cerevisiae [PDF]

, 2019
During meiotic prophase, chromosomes organise into a series of chromatin loops emanating from a proteinaceous axis, but the mechanisms of assembly remain unclear.
A Goloborodko, A Hayashi, A Lengronne, A Storlazzi, A Tedeschi, AL Sanborn, AV Smith, B Bonev, D Thacker, D Zickler, E Alipour, E Crane, E Trelles-Sticken, EF Glynn, EP Nora, EP Nora, F Klein, G Fudenberg, G Fudenberg, G Fudenberg, G Wutz, GA Busslinger, H Jin, H Muller, H Tjong, H Wong, J Dekker, J Dekker, J Gassler, J Li, JA Carballo, JF Marko, JHI Haarhuis, JM Belton, JR Dixon, K Challa, K Nasmyth, KG Alavattam, L Lazar-Stefanita, L Patel, L Xu, M Ito, M Merkenschlager, M Sym, M Sym, MN Conrad, N Naumova, N Servant, NJ Petela, NM Hollingsworth, O Crawley, P Eastman, P Eastman, P Kerpedjiev, PB Møens, Q Jin, S Heinz, S Maleki, S Panizza, SA Schalbetter, SSP Rao, SSP Rao, T Mizuguchi, T Sakuno, TS Hsieh, VV Subramanian, W Schwarzer, Y Blat, Y Kakui, Y Wang   +69 more
core   +2 more sources

Essential and checkpoint functions of budding yeast ATM and ATR during meiotic prophase are facilitated by differential phosphorylation of a meiotic adaptor protein, Hop1 [PDF]

, 2015
A hallmark of the conserved ATM/ATR signalling is its ability to mediate a wide range of functions utilizing only a limited number of adaptors and effector kinases.
A Alcasabas, A Emili, A Traven, AA Ali, Alastair S. Goldman, Ana Penedos, Anthony L. Johnson, B Argunhan, C Chuang, D Bishop, D Durocher, D Durocher, D Lydall, D Ontoso, D Woltering, DK Bishop, Emily Strong, H Cartagena-Lirola, H Lee, H Niu, H Niu, H Tsubouchi, HY Wu, I Acosta, J Falk, J Harper, J Melo, JA Carballo, JA Carballo, JA Carballo, Jesús A. Carballo, JM Bailis, JP Lao, K Hofmann, L Wan, L Xu, M Shinohara, MB Yaffe, Michael Lichten, NM Hollingsworth, NM Hollingsworth, R Suhandynata, Rita S. Cha, RS Cha, S Gray, T Allers, T de los Santos, T Tougan, T Usui, V Busygina, Y Sanchez, YH Lo   +51 more
core   +11 more sources

Dynamic molecular architecture of the synaptonemal complex

bioRxiv, 2020
During meiosis, pairing between homologous chromosomes is stabilized by the assembly of a protein lattice known as the synaptonemal complex (SC).
S. Köhler, Michal Wójcik, Ke Xu, A. Dernburg   +3 more
semanticscholar   +1 more source

Evidence that MEK1 positively promotes interhomologue double-strand break repair [PDF]

, 2010
During meiosis there is an imperative to create sufficient crossovers for homologue segregation. This can be achieved during repair of programmed DNA double-strand breaks (DSBs), which are biased towards using a homologue rather than sister chromatid as ...
Bishop-Bailey, A, Goldman, A.S.H, Johnson, R, Khisroon, M, Neale, Matt, Tarentyev, Y   +5 more
core   +1 more source

The synaptonemal complex central region modulates crossover pathways and feedback control of meiotic double-strand break formation

bioRxiv, 2020
The synaptonemal complex (SC) is a proteinaceous structure that mediates homolog engagement and genetic recombination during meiosis. Zip-Mer-Msh (ZMM) proteins promote crossover (CO) formation and initiate SC formation.
Min-Su Lee, Mika T. Higashide, HyungSeok Choi, Ke Li, Soogil Hong, Kangseok Lee, A. Shinohara, M. Shinohara, K. Kim   +8 more
semanticscholar   +1 more source

Meiotic sex chromosome cohesion and autosomal synapsis are supported by Esco2.

, 2020
In mitotic cells, establishment of sister chromatid cohesion requires acetylation of the cohesin subunit SMC3 (acSMC3) by ESCO1 and/or ESCO2. Meiotic cohesin plays additional but poorly understood roles in the formation of chromosome axial elements (AEs)
Biswas, U., Eichele, G., Hempel, K., Jessberger, R., Kühnel, A., McNicoll, F., Whelan, G.   +6 more
core   +1 more source

Synaptonemal Complexities and Commonalities [PDF]

Molecular Cell, 2003
Formation of synaptonemal complex and high levels of homologous recombination are the hallmarks of meiotic prophase. The relationship between these two processes has been the subject of intense study for nearly 50 years. Recent findings highlight the differences and commonalities of this relationship in different species.
openaire   +2 more sources

Crystal structure of Hop2-Mnd1 and mechanistic insights into its role in meiotic recombination [PDF]

, 2015
In meiotic DNA recombination, the Hop2-Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex by a yet-unclear mechanism.
Alexandra-Styliani Kalantzi, Bergerat, Bishop, Brown, Brunger, Bugreev, Byung-Ha Oh, Case, Chan, Chen, Chi, Cho, Christopher P. Toseland, Cloud, de Massy, De Vlaminck, de Vries, Emsley, Enomoto, Ferrari, Garcia, Haruta, Hayase, Ho-Chul Shin, Holm, Hyun-Ah Kang, Hyun-Min Kim, Keeney, Keeney, Kokabu, Kuwabara, Lange, Leu, Lu, Lu, Lu, Matteo Dal Peraro, Moktan, Morrison, Neale, Okorokov, Otwinowski, Pettersen, Petukhova, Petukhova, Pezza, Pezza, Phillips, Ploquin, Qiao, Rabitsch, Roeder, Rothenberg, Say, Schwacha, Sheridan, Sheridan, Soding, Stephan Gruber, Terwilliger, Tsai, Tsubouchi, Tsubouchi, Uanschou, van der Heijden, Wright, Zhao   +66 more
core   +3 more sources