Results 1 to 10 of about 23,952,755 (264)

Syndecan-1, an indicator of endothelial glycocalyx degradation, predicts outcome of patients admitted to an ICU with COVID-19 [PDF]

Molecular Medicine, 2021
Background We investigated the feasibility of two biomarkers of endothelial damage (Syndecan-1 and thrombomodulin) in coronavirus disease 2019 (COVID-19), and their association with inflammation, coagulopathy, and mortality.
Dong Zhang, Liubing Li, Yu Chen, Jie Ma, Yanli Yang, Surita Aodeng, Qiuju Cui, Kedi Wen, Meng Xiao, Jing Xie, Yingchun Xu, Yongzhe Li   +11 more
doaj   +3 more sources

Serum syndecan-1 is related to severity and prognosis of COVID-19 patients: a perspective cohort study [PDF]

BMC Pulmonary Medicine
Introduction Syndecan-1 is one of cell surface proteoglycans that mediates the connection between cytoskeleton and interstitial matrix. The previous studies have demonstrated that syndecan-1 exerts an essential role in several pulmonary diseases. However,
Mengmeng Ma, Qingqing Zhang, Yongxia Guo, Shushu Li, Ziyong Chen, Kui Liu, Lifang Cao, Meiling Xie, Yingli Wang, Yalin Jiang, Lin Fu   +10 more
doaj   +4 more sources

Serum expression of ESM-1 and Syndecan-1 and its relationship with disease severity in children with Mycoplasma pneumoniae pneumonia [PDF]

Italian Journal of Pediatrics
Background This study aim to investigate the role of endothelial damage in the pathogenesis of Mycoplasma pneumoniae pneumonia (MPP) by comparing serum levels of endothelial cell-specific molecule 1 (ESM-1) and Syndecan-1 in patients with varying degrees
Yanjuan Yu, Yanyan Su, Xiuhong Jin, Xiangfeng Zhang, Yeran Yang, Yuelin Shen   +5 more
doaj   +4 more sources

Syndecan-1 and FGF-2, but not FGF receptor-1, share a common transport route and co-localize with heparanase in the nuclei of mesenchymal tumor cells. [PDF]

PLoS ONE, 2009
Syndecan-1 forms complexes with growth factors and their cognate receptors in the cell membrane. We have previously reported a tubulin-mediated translocation of syndecan-1 to the nucleus.
Fang Zong, Eleni Fthenou, Nina Wolmer, Péter Hollósi, Ilona Kovalszky, László Szilák, Carolin Mogler, Gustav Nilsonne, Georgios Tzanakakis, Katalin Dobra   +9 more
doaj   +3 more sources

Dynamic interplay between sortilin and syndecan-1 contributes to prostate cancer progression. [PDF]

Sci Rep, 2023
Prostate cancer (PCa) development and progression relies on the programming of glucose and lipid metabolism, and this involves alterations in androgen receptor expression and signalling.
Lazniewska J, Li KL, Johnson IRD, Sorvina A, Logan JM, Martini C, Moore C, Ung BS, Karageorgos L, Hickey SM, Prabhakaran S, Heatlie JK, Brooks RD, Huzzell C, Warnock NI, Ward MP, Mohammed B, Tewari P, Martin C, O'Toole S, Edgerton LB, Bates M, Moretti P, Pitson SM, Selemidis S, Butler LM, O'Leary JJ, Brooks DA.   +27 more
europepmc   +2 more sources

Circulating Syndecan-1 as a Predictor of Persistent Thrombocytopenia and Lethal Outcome: A Population Study of Patients With Suspected Sepsis Requiring Intensive Care

Frontiers in Cardiovascular Medicine, 2021
Background: Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host responses to infection. Recent studies have suggested that endotheliopathy may be the common basis for multiple organ failure in sepsis.
Kosaku Hatanaka, Takashi Ito, Yutaro Madokoro, Chinatsu Kamikokuryo, Shuhei Niiyama, Shingo Yamada, Ikuro Maruyama, Yasuyuki Kakihana   +7 more
doaj   +2 more sources

Molecular targets and signaling pathways regulated by nuclear translocation of syndecan-1 [PDF]

BMC Cell Biology, 2017
Background The cell-surface heparan sulfate proteoglycan syndecan-1 is important for tumor cell proliferation, migration, and cell cycle regulation in a broad spectrum of malignancies.
Tünde Szatmári, Filip Mundt, Ashish Kumar-Singh, Lena Möbus, Rita Ötvös, Anders Hjerpe, Katalin Dobra   +6 more
doaj   +2 more sources

Syndecan-1 as a severity biomarker for patients with trauma. [PDF]

Front Med (Lausanne), 2022
Tissue injury and hemorrhage induced by trauma lead to degradation of the endothelial glycocalyx, causing syndecan-1 (SDC-1) to be shed into the blood.
Suzuki K, Okada H, Sumi K, Tomita H, Kobayashi R, Ishihara T, Mizuno Y, Yamaji F, Kamidani R, Miura T, Yasuda R, Kitagawa Y, Fukuta T, Suzuki K, Miyake T, Kanda N, Doi T, Yoshida T, Yoshida S, Tetsuka N, Ogura S, Suzuki A.   +21 more
europepmc   +2 more sources

Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies

Scientific Reports, 2021
Preeclampsia, an important cause of maternal and fetal morbidity and mortality, is associated with increased sFLT1 levels and with structural and functional damage to the glycocalyx contributing to endothelial dysfunction.
H. Hassani Lahsinoui, F. Amraoui, L. J. A. Spijkers, G. J. M. Veenboer, S. L. M. Peters, N. van Vlies, L. Vogt, C. Ris-Stalpers, B. J. H. van den Born, G. B. Afink   +9 more
doaj   +2 more sources

Endothelial damage in septic shock patients as evidenced by circulating syndecan-1, sphingosine-1-phosphate and soluble VE-cadherin: a substudy of ALBIOS [PDF]

Critical Care, 2021
Background Septic shock is characterized by breakdown of the endothelial glycocalyx and endothelial damage, contributing to fluid extravasation, organ failure and death. Albumin has shown benefit in septic shock patients.
Arianna Piotti, Deborah Novelli, Jennifer Marie Theresia Anna Meessen, Daniela Ferlicca, Sara Coppolecchia, Antonella Marino, Giovanni Salati, M. Savioli, Giacomo Grasselli, Giacomo Bellani, Antonio Pesenti, Serge Masson, Pietro Caironi, Luciano Gattinoni, Marco Gobbi, Claudia Fracasso, Roberto Latini, Paolo Bruzzone, Francesca Pagan, R Russo, A Confalonieri, Chiara Abbruzzese, Beatrice Vergnano, Stefano Faenza, Antonio Daniele Pinna, Elisabetta Pierucci, Andrea Noto, Angelo Pezzi, P. Spanu, Vieri Parrini, R Oggioni, G Pasetti, Maria Cinzia Casadio, Rosa Buontempo, Sara Carrer, Francesca Piccoli, Tatiana Rizzi, Anselmo Caricato, Monica La Sala, Alessandra Antonaci, Paola Fassini, Silvia Paganini, Virginia Porta, G Moise, Silvia Marell, Mirella Furia, Maria Cristina Urbano, Roberta Carobbi, Simona Poleni, Hassan Kandil, Andrea Ballotta, F Bettini, Manlio Sanseverino, Alessandro Gatta, Francesca Cecchini, Luca Guatteri, Gabriella Ciceri, Ferdinando Raimondi, Roberto Colombo, S Ferraris, Massimo Borelli, Vittoria Bellato, F Cancellieri, Silvia Senni, Ester Bertocchi, Paola Ferri, Gianpietro Moioli, Andrea Fedele, Alexandra Molin, Giovanni Salati, Pierpaolo Salsi, Emanuela Brunori, Daniele Elisei, Giuseppe Maggio, Federico Nicola, Marco Cavana, Giacomo Morelli, Arturo Guarino, Michele Isetta, G Tulli, Valerio Mangani, Nicola De Rossi, Marta Ferrari, Francesco Bona, Monica Vay, Teresa Bartoli, Mauro Gallo, K. Vettoretto, Mauro Della Morte, Enrico Boselli, Daniela Puscio, Monia Bovo, António Galzerano, Manuela Carli, G Zagara   +94 more
openalex   +2 more sources