Results 91 to 100 of about 23,952,755 (264)

Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?

Arthritis &Rheumatology, Accepted Article.
Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify non‐invasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin, Leonardo Palazzo, Agnes B. Fogo, Mark Haas, David R. W. Jayne, Liz Lightstone, Brad H. Rovin, Surya V. Seshan, Augusto Vaglio, Ioannis Parodis, Ingeborg M. Bajema, The LN classification steering committee   +11 more
wiley   +1 more source

Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice [PDF]

, 2014
INTRODUCTION: Syndecans are heparan sulphate proteoglycans expressed by endothelial cells. Syndecan-3 is expressed by synovial endothelial cells of rheumatoid arthritis (RA) patients where it binds chemokines, suggesting a role in leukocyte trafficking ...
Boyes, C, Eustace, A, Kalia, N, Kehoe, O, King, S, Middleton, J, Patterson, A, Reizes, O, Williams, A   +8 more
core   +4 more sources

Ontogeny of RSPO1, FOXL2, and RUNX1 during ovarian differentiation in the marsupial tammar wallaby

Developmental Dynamics, EarlyView.
Abstract Background RSPO1 and FOXL2 are female sex‐determining genes involved in the differentiation and organization of the ovary in some eutherian mammals. Mutations or loss of function of these genes are associated with partial to full sex reversal in mice, humans, and goats.
Monika R. Paranjpe, Yu Chen, Geoff Shaw, Marilyn B. Renfree   +3 more
wiley   +1 more source

Circulating concentrations of glycocalyx degradation products in preeclampsia

Frontiers in Physiology, 2022
Background and Objectives: Preeclampsia is a multisystem disorder that affects maternal endothelium. The glycocalyx lines and protects the endothelial surface.
Niclas Carlberg, Niclas Carlberg, Catherine Cluver, Catherine Cluver, Catherine Cluver, Camilla Hesse, Sven-Egron Thörn, Sven-Egron Thörn, Robin Gandley, Tor Damén, Tor Damén, Lina Bergman, Lina Bergman, Lina Bergman   +13 more
doaj   +1 more source

PCSK9 and syndecan-1 in renal disease-related dyslipidemia [PDF]

, 2022
Pragyi Shrestha
openalex   +1 more source

Motoneurons secrete angiogenin to induce RNA cleavage in astroglia. [PDF]

, 2012
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disorder affecting motoneurons. Mutations in angiogenin, encoding a member of the pancreatic RNase A superfamily, segregate with ALS.
Aparicio, Isabela M, Breen, Bridget, Concannon, Caoimhin G, Coughlan, Karen, Dussmann, Heiko, Kieran, Dairin, King, Matthew A, Marin, Philippe, Prehn, Jochen HM, Skorupa, Alexandra   +9 more
core   +1 more source

On Top of the Alveolar Epithelium: Surfactant and the Glycocalyx [PDF]

, 2020
Gas exchange in the lung takes place via the air-blood barrier in the septal walls of alveoli. The tissue elements that oxygen molecules have to cross are the alveolar epithelium, the interstitium and the capillary endothelium.
Hegermann, Jan, Kuebler, Wolfgang M., Lopez-Rodriguez, Elena, Matuszak, Jasmin, Nouailles, Geraldine, Ochs, Matthias, Simmons, Szandor, Timm, Sara, Witzenrath, Martin   +8 more
core   +1 more source

The β integrin modulates serotonin sensitivity via NPxY motifs to regulate egg laying and mechanosensation behaviors in Caenorhabditis elegans

Developmental Dynamics, EarlyView.
Abstract Background Integrin is an αβ heterodimeric receptor to the extracellular matrix; its binding to the matrix recruits focal adhesions to two NPxY motifs, the tyrosine phosphorylation sites in the cytoplasmic domain. Studies found that replacing tyrosines (Y) with phenylalanines (F) in the motif of β1 integrin displayed little developmental or ...
Josh Haram Bumm, Daniel Dogeon Lee, Zhongqiang Qiu, Angela Haeun Choi, Meghana Kolluri, Michael J. Olsen, Lianzijun Wang, Myeongwoo Lee   +7 more
wiley   +1 more source

Extracellular Vesicle‐Based mRNA Therapeutics and Vaccines

Exploration, EarlyView.
This review provides a comprehensive analysis of recent advancements in extracellular vesicle (EV)‐based messenger RNA (mRNA) applications for therapeutics and vaccines. It systematically outlines strategies for mRNA encapsulation within EVs and elucidates the challenges associated with this technology, offering insights into future research directions
Qi Li, Haonan Xing, Abid Naeem, Kaiyue Zhang, Aiping Zheng, Yuanyu Huang, Mei Lu   +6 more
wiley   +1 more source

Elevated Plasma Concentrations of Syndecan-1 Do Not Correlate With Increased Capillary Leakage of 20% Albumin.

Anesthesia and Analgesia, 2020
BACKGROUND Preclinical experiments show that an inflammatory reaction causes degradation of the endothelial glycocalyx layer and accelerated capillary leakage of albumin and fluid.
R. Hahn, Markus Zdolsek, Camilla Krizhanovskii, Stelia Ntika, J. Zdolsek   +4 more
semanticscholar   +1 more source