Results 101 to 110 of about 24,222,086 (313)

The monoclonal antibody nBT062 conjugated to maytansinoids has potent and selective cytotoxicity against CD138 positive multiple myeloma cells _in vitro_ and _in vivo_ [PDF]

, 2008
CD138 (Syndecan1) is highly expressed on multiple myeloma (MM) cells. In this study, we examined the anti-MM effect of murine/human chimeric CD138-specific monoclonal antibody (mAb) nBT062 conjugated with highly cytotoxic maytansinoid derivatives _in ...
Benjamin Dä, Christoph Uherek, Diana Cristea, Frank Osterroth, Giulia Perrone, Hiroshi Ikeda, Hiroshi Yasui, Kenneth C. Anderson, Loredana Santo, Mariateresa Fulciniti, Nikhil C. Munshi, Noopur S. Raje, Paul Richardson, Robert J. Lutz, Samantha Pozzi, Silkie Aigner, Sonia Vallet, Tanyel Kiziltepe, Teru Hideshima, Yu-Tzu Tai, Yutaka Okawa   +20 more
core   +1 more source

Temporal glomerular gene expression dynamics during disease progression in a mouse model of hypertension‐accelerated diabetic kidney disease

Animal Models and Experimental Medicine, EarlyView.
The current study characterized temporal changes in glomerular gene expression, pathology, and biomarkers in a mouse model of hypertension‐accelerated diabetic kidney disease (DKD). Progressive albuminuria and glomerulosclerosis were paralleled by dynamic transcriptomic changes associated withmetabolic dysfunction, extracellular matrix remodeling, and ...
Adam B. Marstrand‐Jørgensen, Frederikke Emilie Sembach, Maria Ougaard, Ditte Hansen, Mette Viberg Østergaard, Henrik H. Hansen, Louise S. Dalbøge, Ole Jørgen Kaasbøll, Michael Christensen   +8 more
wiley   +1 more source

Circulating concentrations of glycocalyx degradation products in preeclampsia

Frontiers in Physiology, 2022
Background and Objectives: Preeclampsia is a multisystem disorder that affects maternal endothelium. The glycocalyx lines and protects the endothelial surface.
Niclas Carlberg, Niclas Carlberg, Catherine Cluver, Catherine Cluver, Catherine Cluver, Camilla Hesse, Sven-Egron Thörn, Sven-Egron Thörn, Robin Gandley, Tor Damén, Tor Damén, Lina Bergman, Lina Bergman, Lina Bergman   +13 more
doaj   +1 more source

Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?

Arthritis &Rheumatology, EarlyView.
Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify noninvasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin, Leonardo Palazzo, Agnes B. Fogo, Mark Haas, David R. W. Jayne, Liz Lightstone, Brad H. Rovin, Surya V. Seshan, Augusto Vaglio, Ioannis Parodis, Ingeborg M. Bajema, for the Lupus Nephritis Classification Steering Committee   +11 more
wiley   +1 more source

Motoneurons secrete angiogenin to induce RNA cleavage in astroglia. [PDF]

, 2012
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disorder affecting motoneurons. Mutations in angiogenin, encoding a member of the pancreatic RNase A superfamily, segregate with ALS.
Aparicio, Isabela M, Breen, Bridget, Concannon, Caoimhin G, Coughlan, Karen, Dussmann, Heiko, Kieran, Dairin, King, Matthew A, Marin, Philippe, Prehn, Jochen HM, Skorupa, Alexandra   +9 more
core   +1 more source

Heparanase regulates levels of syndecan-1 in the nucleus. [PDF]

PLoS ONE, 2009
Syndecan-1 is a transmembrane heparan sulfate-bearing proteoglycan known to regulate multiple biological functions at the cell surface and within the extracellular matrix.
Ligong Chen, Ralph D Sanderson
doaj   +1 more source

Integrative single cell RNA‐sequencing and spatial transcriptomics uncovers distinct macrophage‐fibroblast cross‐talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objectives Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, and cell‐cell interactions in FAI and hip OA.
Gulzada Kulzhanova, Alexis Klee, Mina Botros, Victoria L. Hansen, John Reuter, Eliya Tazreena Tashbib, Eloise Fadial, Benjamin F. Ricciardi, Brian Giordano, Chia‐Lung Wu   +9 more
wiley   +1 more source

Regulation of vascular smooth muscle cell calcification by syndecan-4/FGF-2/PKCα signaling and cross-talk with TGFβ [PDF]

, 2017
Aims: Vascular calcification is a major cause of morbidity and mortality. Fibroblast growth factor-2 (FGF-2) plays an instructive role in osteogenesis and bone development, but its role in vascular calcification was unknown.
Alam, Ann E. Canfield, Baeyens, Biver, Catherine L.R. Merry, Chen, Chen, Collett, Debiais, Dombrowski, Fakhry, Galea, Gonzalez, Hagihara, Huang, Hyde, Ju, Kapustin, Krohn, Kuriyama, Latif, Lee, Lehto, Leopold, Lim, Ling, London, Marie, Mark R. Morgan, Montero, Morgan, Morgan, Naganawa, Nakahara, Nakayama, Nakura, Oh, Ornitz, Partovian, Rennenberg, Samantha J. Borland, Sheila E. Francis, Shona C. Borland, Teplyuk, Thomas G. Morris, Turner, Watson, Yan   +47 more
core   +3 more sources

On Top of the Alveolar Epithelium: Surfactant and the Glycocalyx [PDF]

, 2020
Gas exchange in the lung takes place via the air-blood barrier in the septal walls of alveoli. The tissue elements that oxygen molecules have to cross are the alveolar epithelium, the interstitium and the capillary endothelium.
Hegermann, Jan, Kuebler, Wolfgang M., Lopez-Rodriguez, Elena, Matuszak, Jasmin, Nouailles, Geraldine, Ochs, Matthias, Simmons, Szandor, Timm, Sara, Witzenrath, Martin   +8 more
core   +1 more source

The Role of Syndecan-1 in Malignancies

Annals of Medicine, 1996
Syndecans form a family of cell surface proteoglycans, which can interact with various effector molecules, such as extracellular matrix (ECM) molecules and growth factors. Syndecan-1 is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic ...
P, Inki, M, Jalkanen
openaire   +2 more sources