Results 121 to 130 of about 23,952,755 (264)

CLEC18A interacts with sulfated glycosaminoglycans and controls clear cell renal cell carcinoma progression

The FEBS Journal, EarlyView.
CLEC18A is a previously poorly characterized C‐type lectin. We mapped the expression of CLEC18A to the proximal tubule of the kidney and found CLEC18A to interact with sulfated glycosaminoglycans on proteoglycans. Furthermore, we found that CLEC18A plays an important role in hindering the progression of clear cell renal cell carcinomas in humans and in
Gustav Jonsson, Maura Hofmann, Stefan Mereiter, Lauren Hartley‐Tassell, Masahiro Onji, Irma Sakic, Tiago Oliveira, David Hoffmann, Maria Novatchkova, Alexander Schleiffer, Josef M. Penninger   +10 more
wiley   +1 more source

Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics

The FEBS Journal, EarlyView.
We describe the CD9 interactome in epithelial cells for the first time. The interactome is diverse and dynamic and changes dependent on infection with specific bacteria. We validate these data by showing functional interaction between CD9 with CD44 or CD147. We therefore demonstrate that CD9 is a universal organiser of bacterial adhesion platforms able
Paige A. Wolverson, Isabel Fernandes Parreira, Ruth H. Thompson, Mark O. Collins, Jonathan G. Shaw, Luke R. Green   +5 more
wiley   +1 more source

Endothelial glycocalyx degradation is more severe in patients with non-pulmonary sepsis compared to pulmonary sepsis and associates with risk of ARDS and other organ dysfunction

Annals of Intensive Care, 2017
Background Disruption of the endothelial glycocalyx contributes to acute lung injury in experimental sepsis but has not been well studied in humans. To study glycocalyx degradation in sepsis-induced ARDS, we measured plasma levels of syndecan-1, a marker
Laura S. Murphy, Nancy Wickersham, J. Brennan McNeil, Ciara M. Shaver, Addison K. May, Julie A. Bastarache, Lorraine B. Ware   +6 more
doaj   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

The cell surface receptor Tartan is a potential in vivo substrate for the receptor tyrosine phosphatase Ptp52F [PDF]

, 2009
Receptor-linked protein-tyrosine phosphatases (RPTPs) are essential regulators of axon guidance and synaptogenesis in Drosophila, but the signaling pathways in which they function are poorly defined.
Bugga, Lakshmi, Ratnaparkhi, Anuradha, Zinn, Kai   +2 more
core   +2 more sources

Bacterial porphyrins in healthy skin: Microbiota components impact melanogenesis and age‐related processes leading to Porphyr'ageing

International Journal of Cosmetic Science, EarlyView.
Porphyrins, previously linked only to acne inflammation, are now implicated in skin ageing. Their presence correlates with increased melanin, inflammation, and oxidative stress, contributing to premature ageing signs. This study introduces the concept of “Porphyr'ageing,” highlighting the detrimental effects of bacterial metabolites on skin health and ...
Marie Meunier, Morgane De Tollenaere, Cyrille Jarrin, Emilie Chapuis, Marine Bracq, Laura Lapierre, Catherine Zanchetta, Jean Tiguemounine, Amandine Scandolera, Romain Reynaud   +9 more
wiley   +1 more source

Appl1, Sortilin and Syndecan-1 immunohistochemistry on intraductal carcinoma of the prostate provides evidence of retrograde spread [PDF]

, 2023
Alexandra Sorvina, Carmela Martini, Sarita Prabhakaran, Jessica M. Logan, Benjamin S.‐Y. Ung, Courtney R. Moore, I. R. Johnson, Joanna Łaźniewska, Prerna Tewari, Victoria Malone, Robert D. Brooks, Shane M. Hickey, Maria C. Caruso, Sonja Klebe, Litsa Karageorgos, John O’Leary, Brett Delahunt, Hemamali Samaratunga, Doug A. Brooks   +18 more
openalex   +1 more source

Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily [PDF]

, 2008
Background: Drosophila has six receptor protein tyrosine phosphatases (RPTPs), five of which are expressed primarily in neurons. Mutations in all five affect axon guidance, either alone or in combination.
Bahri, Sami, Jeon, Mili, Nguyen, Huong, Zinn, Kai   +3 more
core   +4 more sources

Heparan sulfate proteoglycans: structure, protein interactions and cell signaling [PDF]

, 2009
Heparan sulfate proteoglycans are ubiquitously found at the cell surface and extracellular matrix in all the animal species. This review will focus on the structural characteristics of the heparan sulfate proteoglycans related to protein interactions ...
ABRAMSSON A, ALEXOPOULOU AN, ALLIEL PM, ALMEIDA PC, ARICESCU AR, ASHIKARI-HADA S, ATHANASSIADES A, AVIEZER D, BAEG GH, BAKER AB, BARTLETT AH, BEAUVAIS DM, BECKETT K, BELFORD DA, BELLIN R, BELTING M, BEN-ZAKEN O, BERNFIELD M, BEZAKOVA G, BLACKHALL FH, BOUCHE G, Caio V. Regatieri, CAIZERGUES-FERRER M, CAMPBELL EJ, CANO-GAUCI DF, CAPILA I, CAPILA I, CAPILA I, CAPURRO MI, CARDIN AD, CARNERO A, CASSARO CM, CASU B, CHAVANTE SF, CHEN CL, CHENG F, CHUANG WL, COHEN MM JR, COLE GJ, CONRAD HE, COOMBE DR, CROWN SE, CZUBAYKO F, DEANGELIS PL, DERKSEN PW, DIETRICH CP, DIETRICH CP, DIETRICH CP, DIETRICH CP, DIETRICH CP, DIETZ F, DUCHESNE L, ESCRIBA PV, FAN TC, FARACH-CARSON MC, FARACH-CARSON MC, FEARS CY, FEDARKO NS, FERREIRA TM, FERRO DR, FEYZI E, FILMUS J, FILMUS J, FJELDSTAD K, FOX AN, FRANCO CR, FRANSSON LA, FRANSSON LA, FUKI IV, FUKI IV, FURUKAWA K, GAGLIARDI M, GALLAGHER JT, GAMBARINI AG, GIROS A, GITAY-GOREN H, GLASS DJ, GOMES PB, GRUNERT M, GUERRINI M, GUERRINI M, GUMIENNY TL, HABUCHI H, HACKER U, HANDEL TM, HARMER NJ, HARRISON CA, HAUSSER HJ, Helena B. Nader, HENKE CA, HILEMAN RE, HSIA E, HUBER R, IOZZO RV, IOZZO RV, ISHIHARA M, ISHIHARA M, ISHITSUKA R, JASTREBOVA N, JERONIMO SM, JIANG X, JOHNSON KG, JOHNSON Z, Juliana L. Dreyfuss, JURY EC, KAYED H, KEMP LE, KIRKPATRICK CA, KNOX SM, KOOPMANN W, KREUGER J, KRILLEKE D, LAU EK, LEICHT DT, LEWIS KA, LINDNER JR, LOO BM, LOPES CC, LOPES CC, LORTAT-JACOB H, Lucia O. Sampaio, MA YQ, MIYAZONO K, MOBLI M, MOHAMMADI M, MOHAMMADI M, MONGIAT M, MOREIRA CR, MORGAN MR, MULLOY B, MULLOY B, MULLOY B, MURRAY AJ, NADER HB, NADER HB, NADER HB, NADER HB, NADER HB, NADER HB, NAKADA M, NASCIMENTO FD, NASCIMENTO FD, NG YS, NGO ST, NOTI C, NOZIK-GRAYCK E, NUGENT MA, NUNES SS, OBA-SHINJO SM, OH ES, PADERA R, PANKONIN MS, PARISH CR, PATEL VN, PATEY SJ, PELLEGRINI L, PERETTI T, POON GM, PORCIONATTO MA, PORCIONATTO MA, PORCIONATTO MA, POWELL AK, POWERS CJ, PRESTA M, QUARTO N, RAGAZZI M, RAMAN R, RAPRAEGER AC, RAPRAEGER AC, Renan P. Cavalheiro, RIDER CC, ROHDE LH, ROLNY C, RUBIN JS, RUHRBERG C, SAITO Y, SAKSELA O, SAMPAIO L, SANDERSON RD, SASAKI N, SASAKI S, SASISEKHARAN R, SCHNEPP A, SCHWALL RH, SHINJO SK, SMIRNOV SP, SONCIN F, SONG HH, SPIVAK-KROIZMAN T, STIGLIANO I, STRAUS AH, STRINGER SE, SU G, SUAREZ ER, SUGAYA N, SULPICE E, TANTRAVAHI RV, TAYLOR KR, TELCI D, TERSARIOL IL, TERSARIOL IL, Thais R. Jarrouge, TKACHENKO E, TKACHENKO E, TOLEDO OM, TOUROVSKAIA A, TRAISTER A, UTANI A, VEIGA SS, VEUGELERS M, VEUGELERS M, VIVES RR, VLODAVSKY I, WALKER A, WATT SM, WHITELOCK JM, WIEDLOCHA A, WILCOX-ADELMAN SA, WILKINS-PORT CE, WILLIAMS S, WOJTAL KA, WOODS A, WU DQ, YATES EA, YAYON A, YU WH, YU WH, ZHANG F   +227 more
core   +2 more sources

Ultrasensitive Immunoprofiling of Plasma Extracellular Vesicles Identifies Syndecan-1 as a Potential Tool for Minimally Invasive Diagnosis of Glioma

Clinical Cancer Research, 2019
Purpose: Liquid biopsy has great potential to improve the management of brain tumor patients at high risk of surgery-associated complications. Here, the aim was to explore plasma extracellular vesicle (plEV) immunoprofiling as a tool for noninvasive ...
V. Indira Chandran, C. Welinder, A. Månsson, S. Offer, E. Freyhult, M. Pernemalm, S. Lund, S. Pedersen, J. Lehtiö, G. Marko‐Varga, M. Johansson, E. Englund, P. Sundgren, M. Belting   +13 more
semanticscholar   +1 more source