Results 11 to 20 of about 24,222,086 (313)
Syndecan-1 (CD138), Carcinomas and EMT [PDF]
International Journal of Molecular Sciences, 2021 Cell surface proteoglycans are known to be important regulators of many aspects of cell behavior. The principal family of transmembrane proteoglycans is the syndecans, of which there are four in mammals. Syndecan-1 is mostly restricted to epithelia, and bears heparan sulfate chains that are capable of interacting with a large array of polypeptides ...
J. Couchman
openaire +5 more sources
Syndecan-2 is a novel target of insulin-like growth factor binding protein-3 and is over-expressed in fibrosis [PDF]
PLOS ONE, 2012 Extracellular matrix deposition and tissue scarring characterize the process of fibrosis. Transforming growth factor beta (TGFβ) and Insulin-like growth factor binding protein-3 (IGFBP-3) have been implicated in the pathogenesis of fibrosis in various ...
Adriana T. Larregina +7 more
core +16 more sources
Frontiers in Cardiovascular Medicine, 2021 Background: Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host responses to infection. Recent studies have suggested that endotheliopathy may be the common basis for multiple organ failure in sepsis.
Kosaku Hatanaka +7 more
semanticscholar +3 more sources
Molecular Medicine, 2021 Background We investigated the feasibility of two biomarkers of endothelial damage (Syndecan-1 and thrombomodulin) in coronavirus disease 2019 (COVID-19), and their association with inflammation, coagulopathy, and mortality.
D. Zhang +11 more
semanticscholar +2 more sources
BMC Infectious Diseases, 2023 Background With the emergence of coronavirus disease of 2019 (COVID-19), several blood biomarkers have been identified, including the endothelial biomarker syndecan-1, a surface proteoglycan.
Elina Ghondaghsaz +5 more
semanticscholar +2 more sources
Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies
Scientific Reports, 2021 Preeclampsia, an important cause of maternal and fetal morbidity and mortality, is associated with increased sFLT1 levels and with structural and functional damage to the glycocalyx contributing to endothelial dysfunction.
H. Hassani Lahsinoui +9 more
semanticscholar +2 more sources
Syndecan-1 and FGF-2, but not FGF receptor-1, share a common transport route and co-localize with heparanase in the nuclei of mesenchymal tumor cells. [PDF]
PLoS ONE, 2009 Syndecan-1 forms complexes with growth factors and their cognate receptors in the cell membrane. We have previously reported a tubulin-mediated translocation of syndecan-1 to the nucleus.
Fang Zong +9 more
doaj +3 more sources
Frontiers in Medicine, 2021 Glycocalyx is present on the surface of healthy endothelium, and the concentration of serum syndecan-1 can serve as an injury marker. This study aimed to assess endothelial injury using serum syndecan-1 as a marker of endothelial glycocalyx injury in ...
Keigo Kusuzawa +33 more
semanticscholar +3 more sources
Antirheumatic treatment is associated with reduced serum Syndecan-1 in Rheumatoid Arthritis
PLoS ONE, 2021 The endothelial glycocalyx (EG) is essential for proper function of the endothelium and for vascular integrity, but its role in premature atherogenesis in rheumatoid arthritis (RA) has not been studied yet.
G. Deyab +10 more
semanticscholar +3 more sources
Dynamic interplay between sortilin and syndecan-1 contributes to prostate cancer progression [PDF]
Sci Rep, 2023 Prostate cancer (PCa) development and progression relies on the programming of glucose and lipid metabolism, and this involves alterations in androgen receptor expression and signalling.
Joanna Lazniewska +27 more
semanticscholar +2 more sources