Results 21 to 30 of about 24,222,086 (313)

Elevated plasma syndecan-1 as glycocalyx injury marker predicts unfavorable outcomes after rt-PA intravenous thrombolysis in acute ischemic stroke

Frontiers in Pharmacology, 2022
Purpose: We aimed to examine the prognostic value of syndecan-1 as a marker of glycocalyx injury in patients with acute ischemic stroke (AIS) receiving rt-PA intravenous thrombolysis.
Fangfang Zhao, Rongliang Wang, Yuyou Huang, Lingzhi Li, Liyuan Zhong, Yue Hu, Z. Han, Junfen Fan, Ping Liu, Yangmin Zheng, Yumin Luo   +10 more
semanticscholar   +3 more sources

Serum syndecan-1 is related to severity and prognosis of COVID-19 patients: a perspective cohort study [PDF]

BMC Pulmonary Medicine
Introduction Syndecan-1 is one of cell surface proteoglycans that mediates the connection between cytoskeleton and interstitial matrix. The previous studies have demonstrated that syndecan-1 exerts an essential role in several pulmonary diseases. However,
Mengmeng Ma, Qingqing Zhang, Yongxia Guo, Shushu Li, Ziyong Chen, Kui Liu, Lifang Cao, Meiling Xie, Yingli Wang, Yalin Jiang, Lin Fu   +10 more
doaj   +2 more sources

Cleavage of Syndecan-1 Promotes the Proliferation of the Basal-Like Breast Cancer Cell Line BT-549 Via Akt SUMOylation

Frontiers in Cell and Developmental Biology, 2021
Basal-like breast cancer is characterized by an aggressive clinical outcome and presence of metastasis, for which effective therapies are unavailable.
S. Nadanaka, Yaqiang Bai, H. Kitagawa
semanticscholar   +3 more sources

Molecular functions of syndecan-1 in disease [PDF]

Matrix Biology, 2012
Syndecan-1 is a cell surface heparan sulfate proteoglycan that binds to many mediators of disease pathogenesis. Through these molecular interactions, syndecan-1 can modulate leukocyte recruitment, cancer cell proliferation and invasion, angiogenesis, microbial attachment and entry, host defense mechanisms, and matrix remodeling.
Pyong Woo Park
exaly   +3 more sources

A novel role for syndecan-3 in angiogenesis. [PDF]

F1000Research, 2013
Syndecan-3 is one of the four members of the syndecan family of heparan sulphate proteoglycans and has been shown to interact with numerous growth factors via its heparan sulphate chains.
A Alexopoulou, A Chui, A Chung, A Passaniti, A Pisconti, A Rapraeger, A Rapraeger, C Dealy, C Streuli, D Beauvais, D Cornelison, G De Rossi, G De Rossi, J Chen, J Couchman, J Couchman, J Couchman, J Creemers, J Whiteford, J Whiteford, J Whiteford, M Bespalov, M Chernousov, M Holderfield, M Potente, O Reizes, P Carmeliet, Q Zheng, R Kosher, R Nicosia, R Nolo, S Weis, V Asundi   +32 more
core   +5 more sources

Serum syndecan-1 concentration in hospitalized patients with heart failure may predict readmission-free survival

PLoS ONE, 2021
Syndecan-1 is found in the endothelial glycocalyx and is released into the bloodstream during stressed conditions, including severe diseases such as acute kidney injury, chronic kidney disease, and cardiovascular disease.
Yuichiro Kitagawa, I. Kawamura, Keiko Suzuki, Hideshi Okada, Takuma Ishihara, H. Tomita, Kodai Suzuki, Chihiro Takada, So Sampei, Soichiro Kano, K. Kondo, Hirotaka Asano, Yugo Wakayama, R. Kamidani, Y. Kawasaki, H. Fukuda, Ayane Nishio, Takahito Miyake, Tetsuya Fukuta, Ryu Yasuda, Hideaki Oiwa, Yoshinori Kakino, Nagisa Miyazaki, Takatomo Watanabe, Takahiro Yoshida, T. Doi, A. Suzuki, S. Yoshida, H. Matsuo, Shinji Ogura   +29 more
semanticscholar   +5 more sources

Syndecan-1 as a severity biomarker for patients with trauma [PDF]

Front Med (Lausanne), 2022
Tissue injury and hemorrhage induced by trauma lead to degradation of the endothelial glycocalyx, causing syndecan-1 (SDC-1) to be shed into the blood.
Keiko Suzuki, Hideshi Okada, Kazuyuki Sumi, H. Tomita, R. Kobayashi, Takuma Ishihara, Y. Mizuno, F. Yamaji, R. Kamidani, Tomotaka Miura, Ryu Yasuda, Yuichiro Kitagawa, Tetsuya Fukuta, Kodai Suzuki, Takahito Miyake, Norihide Kanda, T. Doi, Takahiro Yoshida, S. Yoshida, Nobuyuki Tetsuka, Shinji Ogura, A. Suzuki   +21 more
semanticscholar   +2 more sources

Expression of Syndecan-1 in Chronic Liver Diseases: Correlation With Hepatic Fibrosis [PDF]

In Vivo, 2021
Background/Aim: The mechanisms underlying the contribution of the heparan sulfate proteoglycan syndecan-1 to liver tissue injury and to crucial biological processes, such as fibrogenesis, remain to be elucidated.
A. Charchanti, P. Kanavaros, Efthymios Koniaris, A. Kataki, G. Glantzounis, Niki J. Agnantis, A. Goussia   +6 more
semanticscholar   +2 more sources

Serum Syndecan-1 is Associated With Kidney and Cardiovascular Outcomes in Idiopathic Nephrotic Syndrome [PDF]

Kidney International Reports
Introduction: Idiopathic nephrotic syndrome (INS) is associated with important kidney and cardiovascular morbidities. We tested the hypothesis that serum syndecan-1, a marker of endothelial glycocalyx injury, can help identify patients at risk for ...
Colin Bauer, Arshia Anand, Christine Sethna, Jonathan Troost, Tarak Srivastava, Imtiazul Islam, Audrey Fetsko, Julie A. Dougherty, William E. Smoyer, Richard J. Johnson, Gabriel Cara-Fuentes   +10 more
doaj   +2 more sources

Aqueous humor levels of syndecan-1 and syndecan-4 associated with OCTA metrics in diabetic retinopathy [PDF]

Frontiers in Medicine
PurposeAttenuated endothelium glycocalyx had been shown to be related to vascular damage during diabetic retinopathy (DR). Syndecans were pivotal components of retinal glycocalyx, which could be released from the endothelial surface by a highly regulated
Jixian Ma, Yue Bian, Yazhou Qin, Yingni Huang, Yuyao Qu, Li Qin, Anming Xie, Qiuping Liu, Xiayu Xu, Jianqin Lei, Jingming Li   +10 more
doaj   +2 more sources