Heparanase regulates levels of syndecan-1 in the nucleus. [PDF]
PLoS ONE, 2009 Syndecan-1 is a transmembrane heparan sulfate-bearing proteoglycan known to regulate multiple biological functions at the cell surface and within the extracellular matrix.
Ligong Chen, Ralph D Sanderson
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Syndecan-1 and E-Cadherin Expression in Canine Cutaneous Squamous Cell Carcinoma [PDF]
Veterinary SciencesCutaneous squamous cell carcinoma (CSCC) in dogs is a locally invasive tumor that typically occurs in areas of poorly pigmented skin due to sun exposure.
Rita Files +4 more
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Frontiers in Oncology, 2020 The heparan sulfate proteoglycan Syndecan-1 binds cytokines, morphogens and extracellular matrix components, regulating cancer stem cell properties and invasiveness.
Sampath Kumar Katakam +6 more
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Perioperative serum syndecan-1 concentrations in patients who underwent cardiovascular surgery with cardiopulmonary bypass and its association with the occurrence of postoperative acute kidney injury: a retrospective observational study [PDF]
BMC AnesthesiologyBackground Various factors can cause vascular endothelial damage during cardiovascular surgery (CVS) with cardiopulmonary bypass (CPB), which has been suggested to be associated with postoperative complications.
Atsushi Miyazaki +3 more
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Association Between Serum Syndecan 1 Levels and Metabolic Syndrome Parameters: A Comparative Cross-Sectional Study. [PDF]
Endocrinol Diabetes MetabThe results revealed that men in the MetS+ HTN+ ALT+ group had significantly higher serum SDC1 levels than women (20.19 ± 10.56 vs. 11.82 ± 5.09 ng/mL, p = 0.020). Furthermore, in both the total study sample and the MetS+ HTN+ ALT+ group, SDC1 concentrations were positively correlated with diastolic blood pressure (r = 0.256, p = 0.021; r = 0.463, p ...
Tavalaie S +9 more
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Life, 2023 (1) Background: Acute heart failure (HF) represents a complex clinical syndrome burdened by increased mortality and a high rate of systemic complications.
R. Miftode +12 more
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Syndecan-2 is a novel target of insulin-like growth factor binding protein-3 and is over-expressed in fibrosis [PDF]
, 2012 Extracellular matrix deposition and tissue scarring characterize the process of fibrosis. Transforming growth factor beta (TGFβ) and Insulin-like growth factor binding protein-3 (IGFBP-3) have been implicated in the pathogenesis of fibrosis in various ...
Adriana T. Larregina +7 more
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Biochemistry and Biophysics Reports, 2021 Syndecan-1 and syndecan-4 are members of the syndecan family of transmembrane heparan sulfate proteoglycans. Vascular endothelial cells synthesize both species of proteoglycans and use them to regulate the blood coagulation-fibrinolytic system and their ...
Takato Hara +3 more
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Targeting Syndecan-1: New Opportunities in Cancer Therapy.
American Journal of Physiology - Cell Physiology, 2022 Syndecan-1 (SDC1, CD138) is one of the heparan sulfate proteoglycans and is essential for maintaining normal cell morphology, interacting with extracellular and intracellular protein repertoire as well as mediating signaling transduction upon ...
Zecheng Yang +3 more
semanticscholar +1 more source
The Role and Therapeutic Value of Syndecan-1 in Cancer Metastasis and Drug Resistance
Frontiers in Cell and Developmental Biology, 2022 Metastasis and relapse are major causes of cancer-related fatalities. The elucidation of relevant pathomechanisms and adoption of appropriate countermeasures are thus crucial for the development of clinical strategies that inhibit malignancy progression ...
Sen Guo +9 more
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