Results 31 to 40 of about 23,952,755 (264)

Syndecan-1 enhances proliferation, migration and metastasis of HT-1080 cells in cooperation with syndecan-2. [PDF]

PLoS ONE, 2012
Syndecans are transmembrane heparan sulphate proteoglycans. Their role in the development of the malignant phenotype is ambiguous and depends upon the particular type of cancer.
Bálint Péterfia, Tibor Füle, Kornélia Baghy, Krisztina Szabadkai, Alexandra Fullár, Katalin Dobos, Fang Zong, Katalin Dobra, Péter Hollósi, András Jeney, Sándor Paku, Ilona Kovalszky   +11 more
doaj   +1 more source

Syndecan-1 (CD138), Carcinomas and EMT

International Journal of Molecular Sciences, 2021
Cell surface proteoglycans are known to be important regulators of many aspects of cell behavior. The principal family of transmembrane proteoglycans is the syndecans, of which there are four in mammals.
J. Couchman
semanticscholar   +1 more source

Syndecan-1 (CD138) modulates triple-negative breast cancer stem cell properties via regulation of LRP-6 and IL-6-mediated STAT3 signaling. [PDF]

PLoS ONE, 2013
Syndecan-1 (CD138), a heparan sulfate proteoglycan, acts as a coreceptor for growth factors and chemokines and is a molecular marker associated with epithelial-mesenchymal transition during development and carcinogenesis.
Sherif A Ibrahim, Hebatallah Hassan, Laura Vilardo, Sampath Katakam Kumar, Archana Vijaya Kumar, Reinhard Kelsch, Cornelia Schneider, Ludwig Kiesel, Hans Theodor Eich, Ileana Zucchi, Rolland Reinbold, Burkhard Greve, Martin Götte   +12 more
doaj   +1 more source

Interleukin‐34 Reprograms Glycolytic and Osteoclastic Rheumatoid Arthritis Macrophages via Syndecan 1 and Macrophage Colony‐Stimulating Factor Receptor

Arthritis & Rheumatology, 2021
In rheumatoid arthritis (RA), elevated serum interleukin‐34 (IL‐34) levels are linked with increased disease severity. IL‐34 binds to 2 receptors, macrophage colony‐stimulating factor receptor (M‐CSFR) and syndecan 1, which are coexpressed in RA ...
K. van Raemdonck, S. Umar, Karol Palasiewicz, M. Volin, Hatem A. Elshabrawy, Bianca Romay, Chandana Tetali, Azam Ahmed, M. A. Amin, Ryan K. Zomorrodi, N. Sweiss, S. Shahrara   +11 more
semanticscholar   +1 more source

Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate

bioRxiv, 2021
A main clinical parameter of COVID-19 pathophysiology is hypoxia. Here we show that hypoxia decreases the attachment of the receptor binding domain (RBD) and the S1 subunit (S1) of the spike protein of SARS-CoV-2 to epithelial cells.
Endika Prieto-Fernández, L. Egia-Mendikute, Laura Vila-Vecilla, Alexandre Bosch, Adrián Barreira-Manrique, So Young Lee, Ana García-del Río, Asier Antoñana-Vildosola, Borja Jimenez-Lasheras, Leire Moreno-Cugnon, J. Jiménez‐Barbero, E. Berra, J. Ereño-Orbea, A. Palazón   +13 more
semanticscholar   +1 more source

Possible involvement of Syndecan-1 in the state of COVID-19 related to endothelial injury

Thrombosis Journal, 2021
Background The coronavirus infection 2019 (COVID-19) is associated with microvascular endothelial injury. Here, we report that syndecan-1, a component of endothelial glycocalyx, may reflect the disease state of COVID-19 related to endothelial injury ...
Keiko Suzuki, Hideshi Okada, H. Tomita, Kazuyuki Sumi, Yoshinori Kakino, Ryu Yasuda, Yuichiro Kitagawa, Tetsuya Fukuta, Takahito Miyake, S. Yoshida, A. Suzuki, S. Ogura   +11 more
semanticscholar   +1 more source

Neutrophil Extracellular Trap Formation and Syndecan-1 Shedding Are Increased After Trauma

Shock, 2021
Background: Damage-associated molecular patterns (DAMPs) stimulate endothelial syndecan-1 shedding and neutrophil extracellular traps (NET) formation. The role of NETs in trauma and trauma-induced hypercoagulability is unknown.
J. Goswami, Taleen A. Macarthur, K. Bailey, G. Spears, R. Kozar, M. Auton, Jing-fei Dong, N. Key, Stephanie F. Heller, Erica A. Loomis, N. Hall, A. Johnstone, Myung S. Park   +12 more
semanticscholar   +1 more source

Syndecan-1 Promotes Angiogenesis in Triple-Negative Breast Cancer through the Prognostically Relevant Tissue Factor Pathway and Additional Angiogenic Routes

Cancers, 2021
Simple Summary Triple-negative breast cancer is an aggressive subtype of breast cancer characterized by tumor angiogenesis and poor patient survival. Here, we analyzed the function of the cell surface molecule Syndecan-1 in tumor angiogenesis in a 3D ...
E. Nassar, N. Hassan, Eslam A. El-Ghonaimy, Hebatallah Hassan, Mahmoud Salah Abdullah, T. Rottke, L. Kiesel, B. Greve, S. Ibrahim, M. Götte   +9 more
semanticscholar   +1 more source

The effects of a limited infusion rate of fluid in the early resuscitation of sepsis on glycocalyx shedding measured by plasma syndecan-1: a randomized controlled trial

Journal of Intensive Care, 2021
Background Aggressive fluid administration is recommended in the resuscitation of septic patients. However, the delivery of a rapid fluid bolus might cause harm by inducing degradation of the endothelial glycocalyx.
Jutamas Saoraya, Lipda Wongsamita, N. Srisawat, Khrongwong Musikatavorn   +3 more
semanticscholar   +1 more source

The heparan sulfate proteoglycan Syndecan-1 influences local bone cell communication via the RANKL/OPG axis

Scientific Reports, 2020
The heparan sulfate proteoglycan Syndecan-1, a mediator of signals between the extracellular matrix and cells involved is able to interact with OPG, one of the major regulators of osteoclastogenesis.
Melanie Timmen, Heriburg Hidding, Martin Götte, Thaqif El Khassawna, Daniel Kronenberg, Richard Stange   +5 more
doaj   +1 more source