Results 31 to 40 of about 24,222,086 (313)

High Preoperative Serum Syndecan-1, a Marker of Endothelial Glycocalyx Degradation, and Severe Acute Kidney Injury after Valvular Heart Surgery [PDF]

Journal of Clinical Medicine, 2020
Degradation of endothelial glycocalyx (EG) is associated with inflammation and endothelial dysfunction, which may contribute to the development of acute kidney injury (AKI). We investigated the association between a marker of EG degradation and AKI after
Hye-Bin Kim, S. Soh, Y. Kwak, J. Bae, S. Kang, J. Song   +5 more
semanticscholar   +2 more sources

Syndecan-1 Amplifies Angiotensin II–Induced Cardiac Fibrosis [PDF]

Hypertension, 2010
Syndecan-1 (Synd1) is a transmembrane heparan sulfate proteoglycan that functions as a coreceptor for various growth factors and modulates signal transduction. The present study investigated whether Synd1, by affecting growth factor signaling, may play a role in hypertension-induced cardiac fibrosis and dysfunction.
Schellings, Mark W. M., Vanhoutte, Davy, van Almen, Geert C., Swinnen, Melissa, Leenders, Joost J. G., Kubben, Nard, van Leeuwen, Rick E. W., Hofstra, Leo, Heymans, Stephane, Pinto, Yigal M.   +9 more
openaire   +3 more sources

Serum expression of ESM-1 and Syndecan-1 and its relationship with disease severity in children with Mycoplasma pneumoniae pneumonia [PDF]

Italian Journal of Pediatrics
Background This study aim to investigate the role of endothelial damage in the pathogenesis of Mycoplasma pneumoniae pneumonia (MPP) by comparing serum levels of endothelial cell-specific molecule 1 (ESM-1) and Syndecan-1 in patients with varying degrees
Yanjuan Yu, Yanyan Su, Xiuhong Jin, Xiangfeng Zhang, Yeran Yang, Yuelin Shen   +5 more
doaj   +2 more sources

Syndecan-1-Dependent Regulation of Heparanase Affects Invasiveness, Stem Cell Properties, and Therapeutic Resistance of Caco2 Colon Cancer Cells

Frontiers in Oncology, 2020
The heparan sulfate proteoglycan Syndecan-1 binds cytokines, morphogens and extracellular matrix components, regulating cancer stem cell properties and invasiveness.
S. Katakam, P. Pelucchi, C. Cocola, R. Reinbold, I. Vlodavsky, B. Greve, M. Götte   +6 more
semanticscholar   +3 more sources

Syndecan-1 and E-Cadherin Expression in Canine Cutaneous Squamous Cell Carcinoma [PDF]

Veterinary Sciences
Cutaneous squamous cell carcinoma (CSCC) in dogs is a locally invasive tumor that typically occurs in areas of poorly pigmented skin due to sun exposure.
Rita Files, Cláudia Cardoso, Justina Prada, Filipe Silva, Isabel Pires   +4 more
doaj   +2 more sources

Syndecan-1 as a predictor of vulnerable atherosclerotic plaques [PDF]

Front Cell Dev Biol
Yan Qiu, Zhi Ouyang, Jian Zhong, Linlu Jin, Yixue Qin, Ye Zeng   +5 more
openalex   +2 more sources

Syndecan-1: From a Promising Novel Cardiac Biomarker to a Surrogate Early Predictor of Kidney and Liver Injury in Patients with Acute Heart Failure

Life, 2023
(1) Background: Acute heart failure (HF) represents a complex clinical syndrome burdened by increased mortality and a high rate of systemic complications.
R. Miftode, I. Costache, D. Constantinescu, O. Mitu, A. Timpau, M. Hăncianu, D. Leca, Ionela-Larisa Miftode, R.A. Jigoranu, A. Oancea, M. Haba, D. Miftode, I. Șerban   +12 more
semanticscholar   +1 more source

Syndecan-1 downregulates syndecan-4 expression by suppressing the ERK1/2 and p38 MAPK signaling pathways in cultured vascular endothelial cells

Biochemistry and Biophysics Reports, 2021
Syndecan-1 and syndecan-4 are members of the syndecan family of transmembrane heparan sulfate proteoglycans. Vascular endothelial cells synthesize both species of proteoglycans and use them to regulate the blood coagulation-fibrinolytic system and their ...
Takato Hara, Arisa Sato, Chika Yamamoto, Toshiyuki Kaji   +3 more
doaj   +1 more source

Longitudinal Assessment of Plasma Syndecan-1 Predicts 60-Day Mortality in Patients with COVID-19

Journal of Clinical Medicine, 2023
Background: Endotheliopathy is a common pathologic finding in patients with acute and long COVID-19. It may be associated with disease severity and predispose patients to long-term complications.
Quan Zhang, Zhan Ye, Antonia Bignotti, X. Zheng   +3 more
semanticscholar   +1 more source

Endothelial damage in septic shock patients as evidenced by circulating syndecan-1, sphingosine-1-phosphate and soluble VE-cadherin: a substudy of ALBIOS

Critical Care, 2021
Background Septic shock is characterized by breakdown of the endothelial glycocalyx and endothelial damage, contributing to fluid extravasation, organ failure and death. Albumin has shown benefit in septic shock patients.
Arianna Piotti, D. Novelli, J. Meessen, D. Ferlicca, Sara Coppolecchia, A. Marino, G. Salati, M. Savioli, G. Grasselli, G. Bellani, A. Pesenti, S. Masson, P. Caironi, L. Gattinoni, M. Gobbi, C. Fracasso, R. Latini, Paola Francesca Riccarda Andrea Chiara Beatrice Stefano Bruzzone Pagan Russo Confalonieri Abbruzzese Vergn, P. Bruzzone, F. Pagan, R. Russo, A. Confalonieri, C. Abbruzzese, B. Vergnano, S. Faenza, A. Siniscalchi, E. Pierucci, A. Noto, A. Pezzi, P. Spanu, V. Parrini, R. Oggioni, G. Pasetti, M. Casadio, Rosa Buontempo, S. Carrer, F. Piccoli, Tatiana Rizzi, A. Caricato, M. La Sala, A. Antonaci, P. Fassini, Silvia Paganini, V. Porta, G. Moise, Silvia Marell, M. Furia, Maria Cristina Urbano, Roberta Carobbi, Simona Poleni, H. Kandil, A. Ballotta, F. Bettini, M. Sanseverino, A. Gatta, F. Cecchini, Luca Guatteri, G. Ciceri, F. Raimondi, Roberto Colombo, S. Ferraris, Massimo Borelli, V. Bellato, Franco Cancellieri, Silvia Senni, Ester Bertocchi, P. Ferri, Gianpietro Moioli, A. Fedele, A. Molin, G. Salati, P. Salsi, E. Brunori, D. Elisei, Giuseppe Maggio, F. Nicola, M. Cavana, G. Morelli, A. Guarino, Michele Isetta, G. Tulli, V. Mangani, N. Rossi, Marta Ferrari, F. Bona, Monica Vay, Teresa M. Bartoli, Mauro Gallo, K. Vettoretto, M. D. Morte, E. Boselli, D. Puscio, Monia Bovo, A. Galzerano, Manuela Carli, G. Zagara   +95 more
semanticscholar   +1 more source