Results 41 to 50 of about 24,222,086 (313)
Targeting Syndecan-1: New Opportunities in Cancer Therapy.
American Journal of Physiology - Cell Physiology, 2022 Syndecan-1 (SDC1, CD138) is one of the heparan sulfate proteoglycans and is essential for maintaining normal cell morphology, interacting with extracellular and intracellular protein repertoire as well as mediating signaling transduction upon ...
Zecheng Yang +3 more
semanticscholar +1 more source
Syndecan-1 enhances proliferation, migration and metastasis of HT-1080 cells in cooperation with syndecan-2. [PDF]
PLoS ONE, 2012 Syndecans are transmembrane heparan sulphate proteoglycans. Their role in the development of the malignant phenotype is ambiguous and depends upon the particular type of cancer.
Bálint Péterfia +11 more
doaj +1 more source
The Role and Therapeutic Value of Syndecan-1 in Cancer Metastasis and Drug Resistance
Frontiers in Cell and Developmental Biology, 2022 Metastasis and relapse are major causes of cancer-related fatalities. The elucidation of relevant pathomechanisms and adoption of appropriate countermeasures are thus crucial for the development of clinical strategies that inhibit malignancy progression ...
Sen Guo +9 more
semanticscholar +1 more source
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on SDC1 (syndecan 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Purushothaman, A, Sanderson, RD
openaire +2 more sources
Focus on Molecules: Syndecan-1 [PDF]
Experimental Eye Research, 2011 Syndecan-1 (NP_001006947.1) is a widely expressed cell surface heparan sulfate proteoglycan whose molecular cloning as ‘syndecan’ (Saunders et al, ’89), later known as syndecan-1, was the springboard for the discovery of syndecans-2 through -4. Expression in the eye has been documented in corneal, limbal (GDS2433) and conjunctival epithelial cells ...
Yinghui, Zhang +4 more
openaire +2 more sources
bioRxiv, 2021 A main clinical parameter of COVID-19 pathophysiology is hypoxia. Here we show that hypoxia decreases the attachment of the receptor binding domain (RBD) and the S1 subunit (S1) of the spike protein of SARS-CoV-2 to epithelial cells.
Endika Prieto-Fernández +13 more
semanticscholar +1 more source
Syndecan-1 (CD138) modulates triple-negative breast cancer stem cell properties via regulation of LRP-6 and IL-6-mediated STAT3 signaling. [PDF]
PLoS ONE, 2013 Syndecan-1 (CD138), a heparan sulfate proteoglycan, acts as a coreceptor for growth factors and chemokines and is a molecular marker associated with epithelial-mesenchymal transition during development and carcinogenesis.
Sherif A Ibrahim +12 more
doaj +1 more source
Syndecan-1 in Liver Diseases [PDF]
Pathology & Oncology Research, 2019 Liver diseases such as liver cirrhosis, primary and metastatic liver cancers are still a major medical challenge. Syndecan-1 is one of the most important proteoglycans in the liver. Syndecan-1 is normally expressed on the surfaces of hepatocytes and cholangiocytes. Due to liver diseases the amount of syndecan-1 increases in the liver.
Eszter Regős +6 more
openaire +2 more sources
Possible involvement of Syndecan-1 in the state of COVID-19 related to endothelial injury
Thrombosis Journal, 2021 Background The coronavirus infection 2019 (COVID-19) is associated with microvascular endothelial injury. Here, we report that syndecan-1, a component of endothelial glycocalyx, may reflect the disease state of COVID-19 related to endothelial injury ...
Keiko Suzuki +11 more
semanticscholar +1 more source
Neutrophil Extracellular Trap Formation and Syndecan-1 Shedding Are Increased After Trauma
Shock, 2021 Background: Damage-associated molecular patterns (DAMPs) stimulate endothelial syndecan-1 shedding and neutrophil extracellular traps (NET) formation. The role of NETs in trauma and trauma-induced hypercoagulability is unknown.
J. Goswami +12 more
semanticscholar +1 more source