Results 51 to 60 of about 24,222,086 (313)

Syndecan-1 and Syndecan-4 Are Independent Indicators in Breast Carcinoma [PDF]

Journal of Histochemistry & Cytochemistry, 2011
Syndecan proteoglycans may be key regulators of tumor invasion and metastasis because this four-member family of transmembrane receptors regulates cell adhesion, proliferation, and differentiation. Their expression can also serve as prognostic markers.
Lendorf, Maria E, Manon-Jensen, Tina, Kronqvist, Pauliina, Multhaupt, Hinke A B, Couchman, John R   +4 more
openaire   +4 more sources

Interleukin‐34 Reprograms Glycolytic and Osteoclastic Rheumatoid Arthritis Macrophages via Syndecan 1 and Macrophage Colony‐Stimulating Factor Receptor

Arthritis & Rheumatology, 2021
In rheumatoid arthritis (RA), elevated serum interleukin‐34 (IL‐34) levels are linked with increased disease severity. IL‐34 binds to 2 receptors, macrophage colony‐stimulating factor receptor (M‐CSFR) and syndecan 1, which are coexpressed in RA ...
K. van Raemdonck, S. Umar, Karol Palasiewicz, M. Volin, Hatem A. Elshabrawy, Bianca Romay, Chandana Tetali, Azam Ahmed, M. A. Amin, Ryan K. Zomorrodi, N. Sweiss, S. Shahrara   +11 more
semanticscholar   +1 more source

Syndecan-1 Promotes Angiogenesis in Triple-Negative Breast Cancer through the Prognostically Relevant Tissue Factor Pathway and Additional Angiogenic Routes

Cancers, 2021
Simple Summary Triple-negative breast cancer is an aggressive subtype of breast cancer characterized by tumor angiogenesis and poor patient survival. Here, we analyzed the function of the cell surface molecule Syndecan-1 in tumor angiogenesis in a 3D ...
E. Nassar, N. Hassan, Eslam A. El-Ghonaimy, Hebatallah Hassan, Mahmoud Salah Abdullah, T. Rottke, L. Kiesel, B. Greve, S. Ibrahim, M. Götte   +9 more
semanticscholar   +1 more source

The effects of a limited infusion rate of fluid in the early resuscitation of sepsis on glycocalyx shedding measured by plasma syndecan-1: a randomized controlled trial

Journal of Intensive Care, 2021
Background Aggressive fluid administration is recommended in the resuscitation of septic patients. However, the delivery of a rapid fluid bolus might cause harm by inducing degradation of the endothelial glycocalyx.
Jutamas Saoraya, Lipda Wongsamita, N. Srisawat, Khrongwong Musikatavorn   +3 more
semanticscholar   +1 more source

The heparan sulfate proteoglycan Syndecan-1 influences local bone cell communication via the RANKL/OPG axis

Scientific Reports, 2020
The heparan sulfate proteoglycan Syndecan-1, a mediator of signals between the extracellular matrix and cells involved is able to interact with OPG, one of the major regulators of osteoclastogenesis.
Melanie Timmen, Heriburg Hidding, Martin Götte, Thaqif El Khassawna, Daniel Kronenberg, Richard Stange   +5 more
doaj   +1 more source

Syndecan-1 [PDF]

Hypertension, 2010
Cardiac fibrosis is characterized by net accumulation of extracellular matrix in the myocardium and is an integral component of most cardiac pathological conditions. Fibrotic remodeling of the ventricle has profound consequences on cardiac function. Increased deposition of interstitial collagen in the perimysial space is initially associated with a ...
openaire   +1 more source

Nuclear Syndecan-1 Regulates Epithelial-Mesenchymal Plasticity in Tumor Cells

Biology, 2021
Simple Summary The major cause of death in cancer is that tumor cells metastasize (i.e., spread to vital organs such as the lungs and liver). Our knowledge of how metastasis occurs is incomplete and consequently, there is a lack of therapeutic strategies
Ashish Kumar-Singh, M. Parniewska, Nikolina Giotopoulou, Joman Javadi, Wenwen Sun, T. Szatmári, K. Dobra, A. Hjerpe, J. Fuxe   +8 more
semanticscholar   +1 more source

Association of loss of epithelial syndecan-1 with stage and local metastasis of colorectal adenocarcinomas: An immunohistochemical study of clinically annotated tumors

BMC Cancer, 2008
Background Syndecan-1 is a transmembrane proteoglycan with important roles in cell-cell and cell-extracellular matrix adhesion and as a growth factor co-receptor.
Skacel Marek, Hashimoto Yosuke, Adams Josephine C   +2 more
doaj   +1 more source

Novel genes and pathways modulated by syndecan-1: implications for the proliferation and cell-cycle regulation of malignant mesothelioma cells. [PDF]

PLoS ONE, 2012
Malignant pleural mesothelioma is a highly malignant tumor, originating from mesothelial cells of the serous cavities. In mesothelioma the expression of syndecan-1 correlates to epithelioid morphology and inhibition of growth and migration.
Tünde Szatmári, Filip Mundt, Ghazal Heidari-Hamedani, Fang Zong, Elena Ferolla, Andrey Alexeyenko, Anders Hjerpe, Katalin Dobra   +7 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source