Results 61 to 70 of about 23,952,755 (264)

Targeting syndecan-1 in breast cancer inhibits osteoclast functions through up-regulation of osteoprotegerin

Journal of Bone Oncology, 2014
Background: Breast cancer often metastasizes into bone and leads to osteolytic lesions. The underlying mechanisms, however, are complex and not fully understood.
Peggy Benad-Mehner, Stefanie Thiele, Tilman D. Rachner, Andy Göbel, Martina Rauner, Lorenz C. Hofbauer   +5 more
doaj   +1 more source

MMP7 shedding of syndecan-1 facilitates re-epithelialization by affecting alpha(2)beta(1) integrin activation.

PLoS ONE, 2009
BackgroundLung injury promotes the expression of matrix metalloproteinase-7 (MMP7, matrilysin), which is required for neutrophil recruitment and re-epithelialization. MMP7 governs the lung inflammatory response through the shedding of syndecan-1. Because
Peter Chen, Laura E Abacherli, Samuel T Nadler, Ying Wang, Qinglang Li, William C Parks   +5 more
doaj   +1 more source

Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function. [PDF]

, 2019
The endogenous melanocortin peptide agouti-related protein (AgRP) plays a well-known role in foraging, but its contribution to metabolic regulation is less understood.
Chen, Jihuan, Chen, Valerie, Hoang, Ivy, Kawamura, Tomoya, McBride, Ryan, Millhauser, Glenn L, Repunte-Canonigo, Vez, Sanna, Pietro Paolo, Wong, Ashley Tess, Yang, Yang   +9 more
core   +1 more source

Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells

Cell Communication and Signaling, 2020
Background Syndecans regulate cell migration thus having key roles in scarring and wound healing processes. Our previous results have shown that Thy-1/CD90 can engage both αvβ3 integrin and Syndecan-4 expressed on the surface of astrocytes to induce cell
Alejandra Valdivia, Areli Cárdenas, Marianne Brenet, Horacio Maldonado, Milene Kong, Jorge Díaz, Keith Burridge, Pascal Schneider, Alejandra San Martín, Rafael García-Mata, Andrew F. G. Quest, Lisette Leyton   +11 more
doaj   +1 more source

The utility of syndecan-1 circulating levels as a biomarker in patients with previous or active COVID-19: a systematic review and meta-analysis

BMC Infectious Diseases, 2023
Background With the emergence of coronavirus disease of 2019 (COVID-19), several blood biomarkers have been identified, including the endothelial biomarker syndecan-1, a surface proteoglycan.
Elina Ghondaghsaz, Amirmohammad Khalaji, Mitra Norouzi, Douglas D. Fraser, Sanam Alilou, Amir Hossein Behnoush   +5 more
doaj   +1 more source

Pancancer analysis of DNA methylation-driven genes using MethylMix. [PDF]

, 2015
Aberrant DNA methylation is an important mechanism that contributes to oncogenesis. Yet, few algorithms exist that exploit this vast dataset to identify hypo- and hypermethylated genes in cancer.
Gevaert, Olivier, Plevritis, Sylvia K, Tibshirani, Robert   +2 more
core   +2 more sources

Syndecan expressions in the human amnion and chorionic plate

European Journal of Histochemistry, 2010
The syndecan family consists of four distinct membrane glycoproteins in mammals. Syndecans control cell proliferation, differentiation, adhesion and migration through participation in cell-cell interactions, anchorage of cells to the extracellular ...
T. Lorenzi, A. Turi, C. Crescimanno, M. Morroni, M. Castellucci, G. David, A. L. Tranquilli, D. Marzioni   +7 more
doaj   +1 more source

Osteoprotegerin Contributes to the Metastatic Potential of Cells with a Dysfunctional TSC2 Tumor-Suppressor Gene [PDF]

, 1974
In addition to its effects on bone metabolism, osteoprotegerin (OPG), a soluble member of the tumor necrosis factor family of receptors, promotes smooth muscle cell proliferation and migration and may act as a survival factor for tumor cells.
Steagall, Wendy K., Pacheco-Rodriguez, Gustavo, Glasgow, Connie G., Ikeda, Yoshihiko, Lin, Jing-Ping, Zheng, Gang, Moss, Joel   +6 more
core   +1 more source

Specific syndecan-1 domains regulate mesenchymal tumor cell adhesion, motility and migration. [PDF]

PLoS ONE, 2011
BackgroundSyndecans are proteoglycans whose core proteins have a short cytoplasmic domain, a transmembrane domain and a large N-terminal extracellular domain possessing glycosaminoglycan chains. Syndecans are involved in many important cellular processes.
Fang Zong, Eleni Fthenou, Filip Mundt, Tünde Szatmári, Ilona Kovalszky, László Szilák, David Brodin, George Tzanakakis, Anders Hjerpe, Katalin Dobra   +9 more
doaj   +1 more source

Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration. [PDF]

, 2016
Our previous reports indicate that ligand-induced αVβ3 integrin and Syndecan-4 engagement increases focal adhesion formation and migration of astrocytes.
Alvarez, A., Burgos-Bravo, F., Cárdenas, A., Kong, M., Lagos-Cabré, R., Leyton, L., Quest, A.F., Schneider, P.   +7 more
core   +2 more sources