Results 21 to 30 of about 2,222 (191)

A Review of the Human Clinical Studies Involving Citrus aurantium (Bitter Orange) Extract and its Primary Protoalkaloid p-Synephrine

International Journal of Medical Sciences, 2012
This review summarizes the published as well as unpublished human studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine, providing information and an assessment of the safety and efficacy of these widely ...
Sidney J. Stohs, Harry G. Preuss, Mohd Shara
doaj   +1 more source

Co-Existence of Hypertensive and Anti-Hypertensive Constituents, Synephrine, and Nobiletin in Citrus unshiu Peel

Molecules, 2019
A single herb can contain multiple constituents with diverse bioactivities. We found that the extract of Citrus unshiu peel (CUP), induced abnormal vasoconstriction responses on the freshly isolated rat aortic rings in vitro.
Jung-Joon Kim, Keunyoung Kim, Ye-Ryeon Jung, Yiying Bian, Thien Ngo, Ok-Nam Bae, Kyung-Min Lim, Jin-Ho Chung   +7 more
doaj   +2 more sources

STEMI in a Young Male after Use of Synephrine-Containing Dietary Supplement

Case Reports in Cardiology, 2018
A twenty-two-year-old male with no significant past medical history who presented with chest pain was found to have ST-segment elevation in leads II, III, aVF, and V4–V6.
Dileep Unnikrishnan, Radhika Annam, Aasems Jacob, Braghadheeswar Thyagarajan, Peter Farrugia   +4 more
doaj   +2 more sources

Effects of p-Synephrine alone and in Combination with Selected Bioflavonoids on Resting Metabolism, Blood Pressure, Heart Rate and Self-Reported Mood Changes

International Journal of Medical Sciences, 2011
Bitter orange (Citrus aurantium) extract is widely used in dietary supplements for weight management and sports performance. Its primary protoalkaloid is p-synephrine.
Sidney J. Stohs, Harry G Preuss, Samuel C. Keith, Patti L. Keith, Howard Miller, Gilbert R. Kaats
doaj   +1 more source

Synephrine and Its Derivative Compound A: Common and Specific Biological Effects. [PDF]

Int J Mol Sci, 2023
This review is focused on synephrine, the principal phytochemical found in bitter orange and other medicinal plants and widely used as a dietary supplement for weight loss/body fat reduction.
Dodonova SA, Zhidkova EM, Kryukov AA, Valiev TT, Kirsanov KI, Kulikov EP, Budunova IV, Yakubovskaya MG, Lesovaya EA.   +8 more
europepmc   +2 more sources

Recent Advance in the biological activity of synephrine in Citri Reticulatae Pericarpium

European Journal of Medicinal Chemistry Reports, 2022
Synephrine, a natural product also known as deoxyepinephrine, exists in Rutaceae plants and is widely distributed in China. In addition to natural sources, synephrine may also be obtained by means of chemical synthesis and genetic engineering methods. In
Yue-Chang Huang, Jia-Min Li, Bai-Zhong Chen, Xing-Min Zhang, Ri-Hui Wu, Pan-Pan Wu, Chen Li, Wen-Hua Chen   +7 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using ¹H NMR spectroscopy. [PDF]

FEBS Open Bio
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Davies EC, Maker GL, Musgrave IF, Lodge S.   +3 more
europepmc   +2 more sources

Effects of p-Synephrine during Exercise: A Brief Narrative Review [PDF]

, 2021
: p-Synephrine is the principal phytochemical found in bitter orange (Citrus aurantium). This substance is widely included in dietary supplements for weight loss/body fat reduction due to its potential benefits of increasing fat oxidation.
Carlos Ruiz-Moreno, Girález Costas, Verónica, Giráldez-Costas, Verónica, Ruiz-Moreno, Carlos, Juan Del Coso, Del Coso, Juan, González García, Jaime, Gutíerrez-Hellín, Jorge, Gutiérrez Hellín, Jorge, Verónica Giráldez-Costas, Jorge Gutiérrez-Hellín, Ruiz Moreno, Carlos, González-García, Jaime, Jaime González-García   +13 more
core   +1 more source

Synergistic Effect of Composite Chitosan/Phenylalanine Edible Coating on the Postharvest Bioactive Composition of Mandarin Fruit. [PDF]

Food Sci Nutr
Chitosan/Phenylalanine (Chitosan/Phe) composite coating markedly enhanced the postharvest stability and biochemical integrity of mandarin fruit. This treatment effectively extended shelf life to 12 days at ambient conditions and 35 days under cold storage, while significantly increasing polyphenolic and flavonoid content and sustaining antioxidant ...
Jurić S, Vuković M, Bureš MS, Stracenski KS, Donsì F, Bandić LM.   +5 more
europepmc   +2 more sources

p‐Synephrine, ephedrine, p‐octopamine and m‐synephrine: Comparative mechanistic, physiological and pharmacological properties [PDF]

Phytotherapy Research, 2020
AbstractConfusion and misunderstanding exist regarding the lack of cardiovascular and other adverse health effects of p‐synephrine and p‐octopamine relative to ephedrine and m‐synephrine (phenylephrine) which are known for their effects on the cardiovascular system. These four molecules have some structural similarities.
S J Stohs, Mohd Shara, Sidhartha D. Ray
openaire   +2 more sources