Results 111 to 120 of about 158,281 (297)

Demography and the tragedy of the commons

, 2010
Individual success in group-structured populations has two components. First, an individual gains by outcompeting its neighbors for local resources. Second, an individual's share of group success must be weighted by the total productivity of the group ...
Alexander, Alexander, Alizon, Avilés, Bulmer, Buss, Charlesworth, Crespi, Dionisio, Frank, Frank, Frank, Frank, Frank, Frank, Frank, Frank, Frank, Frank, Gardner, Grafen, Hamilton, Hamilton, Hamilton, Hamilton, Hardin, Johnstone, Kokko, Lehmann, Leigh, Levin, Lion, Maynard Smith, Maynard Smith, Nadell, Nagelkerke, Nunney, Oster, Rankin, Rankin, Reece, Szathmáry, Szathmáry, Taylor, Taylor, Thucydides, van Tienderen, West, Wilson   +48 more
core   +2 more sources

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Effect of Clarithromycin on Enhancement of Doxorubicin-induced Cytotoxicity and Apoptosis in A549 Tumor-Cell Line

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: Nowadays, multi-drug regimens or combination therapy are new approaches in cancer treatment that combine two or several therapeutic agents.
Mohammad Shokrzadeh, Fatemeh Shaki, Nahid Amani   +2 more
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Natural Baicalein-Rich Fraction as Radiosensitizer in Combination with Bismuth Oxide Nanoparticles and Cisplatin for Clinical Radiotherapy

International Journal of Nanomedicine, 2022
Noor Nabilah Talik Sisin,1 Nor Fazila Che Mat,1 Raizulnasuha Ab Rashid,1 Norhayati Dollah,2 Khairunisak Abdul Razak,3 Moshi Geso,4 Merfat Algethami,5 Wan Nordiana Rahman1 1School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan ...
Sisin NNT, Mat NFC, Rashid RA, Dollah N, Razak KA, Geso M, Algethami M, Rahman WN   +7 more
doaj  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Pd/fMC−NiO Synergistic, Promotional Effect and Cooperation Induced Electrocatalysis towards Ethylene Glycol Electrooxidation: Experimental Approach and DFT Calculations

ChemElectroChem
Direct alcohol fuel cells (DAFCs) face several challenges such as carbon support corrosion, poor kinetics, and long‐term stability, requiring improved electrocatalyst support development.
Thabo Matthews, Dr. Tarekegn H. Dolla, Siyabonga P. Mbokazi, Makhaokane P. Chabalala, Dr. Julia Gallenberger, Prof. Jan P. Hofmann, Dr. Kiarii E. Muriithi, Prof. Penny P. Govender, Prof. Nobanathi W. Maxakato   +8 more
doaj   +1 more source