Results 71 to 80 of about 220,441 (262)
An analysis of mutational signatures of synonymous mutations across 15 cancer types
BMC Medical Genetics, 2019 Background Synonymous mutations have been identified to play important roles in cancer development, although they do not modify the protein sequences.
Yannan Bin +4 more
doaj +1 more source
Advanced Science, EarlyView.CA9‐targeted PET imaging could be a noninvasive approach to characterize clear cell renal cell carcinoma and associated tumor biology. PET uptake correlates with tumor CA9 expression and is linked to angiogenic activity, immune remodeling, and metabolic reprogramming.
Kailei Chen +19 more
wiley +1 more source
Relative frequencies of synonymous and non-synonymous polymorphisms.
, 2012 Note: Alleles, number of unique sequences. dN, average frequency of non-synonymous mutations per potential non-synonymous site. dS, average frequency of synonymous mutations per potential synonymous site. ω, dN/dS.
François-Xavier Weill (157212) +12 more
core +1 more source
Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7
Advanced Science, EarlyView.Prime Editor 7‐mediated conversion of APOE4 to APOE3 alleviates Alzheimer's disease‐associated pathology in AD mouse models and patient‐derived neurons and improves cognitive performance in vivo, supporting therapeutic genome editing as a promising strategy for APOE4‐associated neurodegeneration.
Yunkyung Kim +16 more
wiley +1 more source
Evidence that synonymous mutations and synonymous gene variants have fitness effects have accumulated recently. Since horizontal gene transfer represents a change in the genome of expression of the transferred gene, we hypothesized that the codon usage ...
Hamet, Jeanne +4 more
core +1 more source
Analysis of synonymous and non-synonymous changes in cassava SNPs.
, 2014 Detailed information regarding the changes introduced by nucleotide substitutions and their distribution according to the nucleotide position within codons.Analysis of synonymous and non-synonymous changes in cassava SNPs.
Chutima Sonthirod (680896) +9 more
core +1 more source
Advanced Science, EarlyView.This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo +17 more
wiley +1 more source
Structural impact of synonymous mutations in six SARS-CoV-2 Variants of Concern.
PLoS ONESARS-CoV-2 continues to spread and infect people worldwide. While most effort into characterizing variants of this virus have focused on non-synonymous changes, accumulation of synonymous mutations in different viral variants has also occurred.
Alison Ziesel, Hosna Jabbari
doaj +1 more source
KAJIAN ASINONIMITAS AL-KITAB WAL AL-QUR’AN: QIRA’AH MUASHIRAH
Lingua: Jurnal Bahasa, Sastra dan Pengajarannya, 2017 This research describes the concept of Muhammad Syahrur on the birth of asynonymous theory, the ignorance of synonymous in the Qur'an. Synonymous in the Qur'an is frequently discussed, but debates appear where Syahrur is in disagreement.
Mia Fitriah Elkarimah
doaj +1 more source