Results 51 to 60 of about 74,456 (251)

Strong purifying selection at synonymous sites in D. melanogaster. [PDF]

PLoS Genetics, 2013
Synonymous sites are generally assumed to be subject to weak selective constraint. For this reason, they are often neglected as a possible source of important functional variation.
David S Lawrie, Philipp W Messer, Ruth Hershberg, Dmitri A Petrov   +3 more
doaj   +1 more source

A Novel Synonymous Mutation of SARS-CoV-2: Is This Possible to Affect Their Antigenicity and Immunogenicity?

Vaccines, 2020
The S glycoprotein of coronaviruses is important for viral entry and pathogenesis with most variable sequences. Therefore, we analyzed the S gene sequences of SARS-CoV-2 to better understand the antigenicity and immunogenicity of this virus in this study.
Sung-Jae Kim, V. Nguyen, Y. Park, B. Park, H. Chung   +4 more
semanticscholar   +1 more source

Identity and Semantic Synonymy As Avicenna's Innovative Theory in The Problem of Being Impossible in Abstraction Plurality of the Unit in Al-Ta'liqat

حکمت سینوی, 2020
Avicenna has provided a solution to the problem of abstraction plurality of the unit. In order to eliminate problems such as pluralityin the divine essence and abstraction pluralityfrom the unit, he must first solve the problem of pluralityin Properties.
Hassan Rahbar, Morteza Erfani, Lailaa Nikooyenejaad   +2 more
doaj  

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Synonymous Structures in English Syntax

Armenian Folia Anglistika, 2018
Synonymy is one of the most important sources of the wealth of language and is closely related to the problems of stylistics, speech culture, language changes and language improvements.
Jemma Militonyan
doaj   +1 more source

Synonymous but not the same: the causes and consequences of codon bias

Nature reviews genetics, 2010
Despite their name, synonymous mutations have significant consequences for cellular processes in all taxa. As a result, an understanding of codon bias is central to fields as diverse as molecular evolution and biotechnology.
J. Plotkin, Grzegorz Kudla
semanticscholar   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Synonymous codon substitutions perturb cotranslational protein folding in vivo and impair cell fitness

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Many proteins that are incapable of refolding in vitro nevertheless fold efficiently to their native state in the cell. This suggests that more information than the amino acid sequence is required to properly fold these proteins.
Ian M. Walsh, Micayla A. Bowman, Iker F. Soto Santarriaga, A. Rodríguez, P. Clark   +4 more
semanticscholar   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Synonymous GATA2 mutations result in selective loss of mutated RNA and are common in patients with GATA2 deficiency

Leukemia, 2020
Deficiency of the transcription factor GATA2 is a highly penetrant genetic disorder predisposing to myelodysplastic syndromes (MDS) and immunodeficiency. It has been recognized as the most common cause underlying primary MDS in children. Triggered by the
E. Kozyra, V. Pastor, Stylianos Lefkopoulos, S. Sahoo, H. Busch, R. Voss, M. Erlacher, D. Lebrecht, E. Szvetnik, Shinsuke Hirabayashi, Ramunė Pasaulienė, L. Pedace, M. Tartaglia, C. Klemann, Patrick Metzger, Melanie Boerries, A. Catalá, H. Hasle, V. de Haas, K. Kállay, R. Masetti, B. De Moerloose, M. Dworzak, M. Schmugge, O. Smith, J. Starý, E. Mejstříková, M. Ussowicz, E. Morris, Preeti Singh, M. Collin, Marta Derecka, G. Göhring, C. Flotho, B. Strahm, F. Locatelli, C. Niemeyer, E. Trompouki, M. Wlodarski   +38 more
semanticscholar   +1 more source