Results 61 to 70 of about 220,441 (262)
Synonymous and non-synonymous SNP incidence.
, 2014 A: Exonic SNPs in 98 genes known to be lethal or severely debilitating if deleted (a subset of genes in Figure 1A with at least one exonic SNP (Table S2)); B: Survey of 13,820 genes for which data was accessible from the Exon-Intron Database (http://www ...
Hemant Tiwari (29034) +7 more
core +1 more source
Advanced Science, EarlyView.Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin +20 more
wiley +1 more source
Synonymous (Ks) and non-synonymous (Ka) substitutions.
, 2015 Average overall Ks and Ka substitutions and the Ka/Ks ratio for each ORF as assessed with MEGA6 using the Kimura model. Values for Ka/Ks >1 indicated in bold type represent evidence for positive selection.Synonymous (Ks) and non-synonymous (Ka ...
Johan T. Burger (587759) +5 more
core +1 more source
The Mind From Within: Visceral Roots of Human Cognition
Advanced Science, EarlyView.The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti +1 more
wiley +1 more source
Analysis of synonymous and non-synonymous SNPs of ORF sequences.
, 2015 Analysis of synonymous and non-synonymous SNPs of ORF sequences.
Takeshi Inoue (208656) +7 more
core +1 more source
Ethical Precision in Nanoscale Brain Interfacing
Advanced Science, EarlyView.As brain interfaces approach the nanoscale, precision no longer only measures—it knows, predicts, and potentially reshapes the mind. This work argues that traditional ethics fails under such conditions and proposes a shift toward continuous, operation‐based governance using the recovery–discovery framework to track, constrain, and responsibly steer ...
Guilherme Wood
wiley +1 more source
Advanced Science, EarlyView.This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita +4 more
wiley +1 more source
Non-synonymous and synonymous coding SNPs show similar likelihood and effect size of human disease association. [PDF]
PLoS ONE, 2010 Many DNA variants have been identified on more than 300 diseases and traits using Genome-Wide Association Studies (GWASs). Some have been validated using deep sequencing, but many fewer have been validated functionally, primarily focused on non ...
Rong Chen +3 more
doaj +1 more source
The Fitness Effects of Synonymous Mutations in DNA and RNA Viruses
, 2011 Despite being silent with respect to protein sequence, synonymous nucleotide substitutions can be targeted by natural selection directly at the DNA or RNA level.
Rafael Sanjuán +5 more
core +1 more source
Advanced Science, EarlyView.A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...
Qun Ma +11 more
wiley +1 more source