Results 211 to 220 of about 660,576 (241)

Synonymous mutations in essential genes infrequently produce fitness effects in human cell lines. [PDF]

Nucleic Acids Res
Rao Y, Sokirniy I, O'Brien E, Pritchard J.   +3 more
europepmc   +1 more source

Mitochondrial DNA mutations are associated with impaired oxidative phosphorylation and enhanced imatinib response in chronic myeloid leukemia. [PDF]

Hemasphere
Pagani IS, Krishnan V, Ouyang JF, Kok CH, Chen B, Lee KL, Pham CM, Wang P, Page E, Dang P, Saunders VA, James J, Lim K, Mangiola S, Gao Y, Shanmuganathan N, Yong A, Branford S, Chuah C, Yeung DT, White DL, Helgason VG, Thomas D, Ong ST, Hughes TP, Ross DM.   +25 more
europepmc   +1 more source

Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis—A synthesis of recent findings

Periodontology 2000, EarlyView.
AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer, Luigi Nibali, Noha Zoheir, Niki M. Moutsopoulos, Bruno G. Loos   +4 more
wiley   +1 more source

Virulence Profiles and Fungicide-Target-Gene Variability in <i>Puccinia graminis</i> f. sp. <i>tritici</i> Populations from Russian Regions. [PDF]

J Fungi (Basel)
Dudnikova K, Baranova O, Shingaliev A, Lap LQ, Polkhovskaya E, Kirov I, Dudnikov M.   +6 more
europepmc   +1 more source

Deciding What to Believe or Deciding What to Do? An Empirical Investigation of the Folk Conception of Critical Thinking

Theoria, EarlyView.
ABSTRACT This study investigates how the expression ‘critical thinking’ (CT) is understood and used by the general public in the United States, using the tools of experimental philosophy. Based on responses from 288 non‐philosopher participants, our findings suggest that CT is commonly associated with problem solving, decision making and logical ...
Céline Schöpfer, Julia Ghaliounghi, Florian Cova   +2 more
wiley   +1 more source

A novel synonymous TSC2 mutation in a Chinese family leads to tuberous sclerosis type 2 by disrupting Normal pre-mRNA splicing. [PDF]

J Genet Eng Biotechnol
Zhang C, Li S, Leng R, Deng M, Yang G.
europepmc   +1 more source

Investigating the molecular basis of the serological Rh D‐negative phenotype in Indonesia: nature, frequency, and impact for diagnostics

Transfusion, EarlyView.
Abstract Background Although widely studied and reported for more than 30 years, the molecular basis of Rh D‐negativity has remained unexplored in several regions of the world, including in Indonesia, Southeast Asia. Study Design and Methods A subset of 436 Indonesian blood donors originally typed D‐negative (D–) by routine serological testing was ...
Tonny Wongso, Teguh Triyono, Caroline Bénech, Gauthier Thomas, Sasi Widuri, Martono Adi Triyogo, Ni Kadek Mulyantari, Misnah Syarifuddin, Halimi Maksum, Winda Astuti Taruno, Hasna Fadlilatul Bidayah, Yann Fichou   +11 more
wiley   +1 more source

Sexual selection purges mutation load, but not overall genetic diversity, decreasing vulnerability to extinction. [PDF]

Proc Natl Acad Sci U S A
Pointer MD, Nash WJ, Gage MJG, Chapman T, Maklakov AA, Richardson DS.   +5 more
europepmc   +1 more source

<i>TP53</i> mutation drives unique transcriptional and functional vulnerabilities independent of del(17p) in multiple myeloma. [PDF]

iScience
Tsallos D, Ikonen N, Miettinen JJ, Majumder MM, Eldfors S, Västrik I, Parsons A, Suvela M, Dunphy K, Dowling P, Bazou D, O'Gorman P, Lievonen J, Silvennoinen R, Anttila P, Heckman CA.   +15 more
europepmc   +1 more source

The distribution of fitness effects of nonsynonymous mutations varies phylogenetically across animals. [PDF]

PLoS Biol
Lin M, Chakraborty S, Amorim CEG, Nigenda-Morales SF, Beichman AC, Nuñez-Valencia PG, Mah JC, Robinson JA, Kyriazis CC, Huber CD, Webb AE, Kocher SD, Archer FI, Moreno-Estrada A, Wayne RK, Lohmueller KE.   +15 more
europepmc   +1 more source