Results 81 to 90 of about 660,576 (241)

Strong mutation testing strategies [PDF]

, 1993
Mutation Testing (or Mutation Analysis) is a source code testing technique which analyses code by altering code components. The output from the altered code is compared with output from the original code.
Duncan, Ishbel M.M.
core  

Modelling the effects of single point mutations on the structure and function of proteins [PDF]

, 2009
Insight into the molecular impact of mutations on the structure and function of proteins is of great importance in biology. It helps understand the evolution of proteins, rationalize the molecular causes of disease and, from a practical perspective, aid ...
Battey, James Nicolas Duncan
core   +1 more source

Systematic pathway‐level analysis defines conserved transcriptional divergence between primary lung tumors and cell line models

Animal Models and Experimental Medicine, EarlyView.
Lung cancer cell lines diverge substantially from primary tumors at the transcriptional level. Using single‐sample gene set enrichment analysis and L1‐penalized feature selection across TCGA‐LUAD and CCLE‐LUAD, we identified five Hallmark pathways (E2F targets, G2M checkpoint, IFNγ response, coagulation, and EMT) that discriminated primary tumors from ...
Pritam Bera, Rajesh Raju, Debodipta Das
wiley   +1 more source

Host-dependent C-to-U RNA editing in SARS-CoV-2 creates novel viral genes with optimized expressibility

Frontiers in Cellular and Infection Microbiology
Rampant C-to-U RNA editing drives the mutation and evolution of SARS-CoV-2. While much attention has been paid to missense mutations, the C-to-U events leading to AUG and thus creating novel ORFs were uninvestigated.
Pirun Zhang, Wenli Zhang, Jiahuan Li, Huiying Liu, Yantong Yu, Xiaoping Yang, Xiaoping Yang, Wenqing Jiang, Wenqing Jiang   +8 more
doaj   +1 more source

Different frequency patterns of synonymous, non-synonymous and nonsense mutations.

, 2018
As expected, in the HIV pol gene, synonymous mutations occurred more frequently than non-synonymous mutations, which occurred more frequently than nonsense mutations, which were not observed at all.
Marion Hartl (5464361), Kristof Theys (88458), Adi Stern (269436), Alison F. Feder (201256), Pleuni S. Pennings (513430), Maoz Gelbart (5464358)   +5 more
core   +1 more source

Comparative analysis of TP53 gene in Tupaia belangeri subspecies (Tupaia belangeri yaoshanensis vs. Tupaia belangeri chinensis) and identification of mutations in spontaneous tumor cases

Animal Models and Experimental Medicine, EarlyView.
This study provides the first evidence of natural TP53 variation between tree shrew subspecies and identifies somatic TP53 mutations in spontaneous tree shrew sarcomas. The high structural and functional conservation of tree shrew p53 with humans supports its utility as a relevant model for TP53‐related cancer research.
Yingying Cao, Haibo Tang, Liang Liang, Jing Leng, Weijian Huang   +4 more
wiley   +1 more source

Analysis of synonymous codon usage in Hepatitis A virus

Virology Journal, 2011
Background Hepatitis A virus is the causative agent of type A viral hepatitis, which causes occasional acute hepatitis. Nevertheless, little information about synonymous codon usage pattern of HAV genome in the process of its evolution is available.
Ma Lina, Wang Yin, Chen Haotai, Zhou Jianhua, Liu Wenqian, Liu Yongsheng, Zhang Yiqiang, Ding Yaozhong, Zhang Jie   +8 more
doaj   +1 more source

Origin, evolution and biogeographic dynamics of the European rabbit (Oryctolagus cuniculus) in Southwestern Europe

The Anatomical Record, EarlyView.
Abstract The Pleistocene is a key period for understanding the evolutionary history and palaeobiogeography of the European rabbit (Oryctolagus cuniculus). The species was first documented in southeastern Iberia at the beginning of the Middle Pleistocene and appears to have rapidly spread throughout Southwestern Europe, where it was found in numerous ...
Maxime Pelletier
wiley   +1 more source

Rethinking brachycephaly: Anatomical implications and health considerations in lagomorphs

The Anatomical Record, EarlyView.
Abstract Brachycephaly in domestic rabbits is increasingly perceived by welfare organizations as associated with significant health complications, particularly oral pathologies. Despite this perception, comparative anatomical research into rabbit brachycephaly is limited compared to that of dogs and cats, compelling an in‐depth examination of its ...
Helaina Cressy, Alice Nishigaki, Matthew C. Gage, Renato L. Previdelli   +3 more
wiley   +1 more source

Alta prevalencia de la mutación CBS p.T191M en pacientes homocistinúricos de Colombia

, 2006
8 páginasHomocystinuria is an autosomal recessive disease most commonly caused by mutationsin cystathionine ß-synthase (CBS). In this study we present the mutation analysis of 36 Colombian individuals from 10 unrelated kindred, with 11 ...
Frank, Nina, Balcells, Susana, Bernal, Jaime, Ugarte, Magdalena, Urreizti, Roser, Bermúdez, Marta, Briceño, Ignacio, Grinberg, Daniel, Merinero, Begoña, Perez Cerdá, Celia, Jan, P. Kraus   +10 more
core   +1 more source