Results 51 to 60 of about 1,278,587 (252)
Advanced Science, EarlyView.Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao +7 more
wiley +1 more source
Efficacy of synovial fluid analysis and synovial biopsy in diagnosing joint pathologies
, 2018 Introduction: Joint disease is a common orthopaedic problem. They often occur in younger people and tend to be destructive. This can lead to widespread disability and morbidity.
G. Santhosh, P. Madhuchandra, K. Raju
semanticscholar +1 more source
The Lancet Rheumatology, 2023 BACKGROUND Despite highly effective targeted therapies for rheumatoid arthritis, about 40% of patients respond poorly, and predictive biomarkers for treatment choices are lacking.
F. Rivellese +36 more
semanticscholar +1 more source
Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis
Arthritis &Rheumatology, EarlyView.Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm +2 more
wiley +1 more source
US-Guided Biopsies: Overarching Principles
Frontiers in Medicine, 2019 Gathering synovial tissue from any swollen joint especially in early arthritis patients is critical for good quality research and to obtain further insight into the pathophysiology of inflammatory joint diseases.
Laurent Meric De Bellefon +2 more
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective Rheumatoid arthritis (RA) often involves extra‐articular complications, including interstitial lung disease (ILD) and/or pulmonary nodules. Transcriptomic profiling of lung tissue provides the opportunity to directly assess cell‐specific gene expression and corresponding pathway activation in different types of rheumatoid lung disease ...
Tracy Tabib +8 more
wiley +1 more source
, 2001 Background/Aims - Synovial fluid examination is thought to be the pathological investigation of choice in most joint disorders, with only a few specific conditions necessitating biopsy, although no evidence based studies are available to support this ...
Johnson, J. S. +2 more
core +1 more source
Approximate Analytical Model for the Squeeze-Film Lubrication of the Human Ankle Joint with Synovial Fluid Filtrated by Articular Cartilage [PDF]
, 2010 The aim of this article is to propose an analytical approximate squeeze-film lubrication model of the human ankle joint for a quick assessment of the synovial pressure field and the load carrying due to the squeeze motion.
Emilio Gòmez +5 more
core +1 more source
Frontiers in Medicine, 2018 Introduction: Identifying and quantifying inflammatory disease activity in rheumatoid arthritis remains a challenge. Many studies have suggested that a large proportion of patients may have active inflammation, but normal inflammatory markers.
Carl K. Orr +6 more
doaj +1 more source
Synovial Sarcoma: A Clinical Review
Current Oncology, 2021 Synovial sarcomas (SS) represent a unique subset of soft tissue sarcomas (STS) and account for 5–10% of all STS. Synovial sarcoma differs from other STS by the relatively young age at diagnosis and clinical presentation.
A. Gazendam +5 more
semanticscholar +1 more source