Results 1 to 10 of about 96,691 (106)

Synovial Fluid Cell Counts and the Degree of Synovial Tissue Lymphocytic Inflammation in Patients with Rheumatoid Arthritis [PDF]

ACR Open Rheumatology
Objective The synovial tissue pathotype may determine the treatment response in rheumatoid arthritis (RA); however, biopsies are not widely available. Synovial fluid is a promising tissue surrogate.
Susan M. Goodman, Michael Parides, Solana Cushing, Daniel Ramirez, Edward DiCarlo, Kristine Carandang, Renée A. Davis, Rebecca B. Blank, Laura T. Donlin, Anna Helena Jonsson, Amit Lakhanpal, Bella Mehta, Dana Orange, Melanie H. Smith   +13 more
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Synovial Tissue Biopsy Research

Frontiers in Medicine, 2019
Synovial tissue is a key structure in diarthrodial joints and is the primary target of inflammation in autoimmune arthritis. The study of synovial tissue has developed significantly in the last two decades as arthroscopic and ultrasonographic techniques ...
Douglas J. Veale
doaj   +3 more sources

Immunohistological characterization of equine synovial tissue in metacarpophalangeal joints of different ages and osteoarthritis status [PDF]

Osteoarthritis and Cartilage Open
Objective: Synovial macrophages' role in equine osteoarthritis (OA) is not well understood, despite horses being a model for human degenerative joint disorders.
Giulia Liso, Karsten Winter, Theresa Jenny Triebe, Reiner Ulrich, Walter Brehm, Bettina Wagner, Christiane Liliane Schnabel, Antonia Troillet, Susanne Pauline Roth   +8 more
doaj   +2 more sources

Synovial tissue from sites of joint pain in knee osteoarthritis patients exhibits a differential phenotype with distinct fibroblast subsets

EBioMedicine, 2021
Background: Synovial inflammation is associated with pain severity in patients with knee osteoarthritis (OA). The aim here was to determine in a population with knee OA, whether synovial tissue from areas associated with pain exhibited different synovial
Dominika E Nanus, Amel Badoume, Susanne N Wijesinghe, Andrea M Halsey, Patrick Hurley, Zubair Ahmed, Rajesh Botchu, Edward T Davis, Mark A Lindsay, Simon W Jones   +9 more
doaj   +3 more sources

Peptidoglycan in osteoarthritis synovial tissue is associated with joint inflammation [PDF]

Arthritis Research & Therapy
Objectives Peptidoglycan (PG) is an arthritogenic bacterial cell wall component whose role in human osteoarthritis is poorly understood. The purpose of this study was to determine if PG is present in synovial tissue of osteoarthritis patients at the time
Meaghan N Holub, Amanda Wahhab, Joseph R Rouse, Rebecca Danner, Lauren G Hackner, Christine B Duris, Mecaila E McClune, Jules M Dressler, Klemen Strle, Brandon L Jutras, Adam I Edelstein, Robert B Lochhead   +11 more
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Integrated Single-Cell and Bulk RNA Sequencing Reveals the Diagnostic Value of Synovial Tissue Calprotectin and the MDSC-Associated Immune Microenvironment in Periprosthetic Joint Infection [PDF]

Infection and Drug Resistance
Ying Tuo,1,* Yang Xing,2,3,* Chenghan Chu,2,3 Zhiqing Xiao,4 Puyi Sheng,2,3 Xiaoyu Wu2,3 1Department of Pathology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, People’s Republic of China; 2Department of ...
Tuo Y, Xing Y, Chu C, Xiao Z, Sheng P, Wu X   +5 more
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Molecular maps of synovial cells in inflammatory arthritis using an optimized synovial tissue dissociation protocol [PDF]

iScience
Summary: In this study, we optimized the dissociation of synovial tissue biopsies for single-cell omics studies and created a single-cell atlas of human synovium in inflammatory arthritis.
Sam G. Edalat, Reto Gerber, Miranda Houtman, Janine Lückgen, Rui Lourenço Teixeira, Maria del Pilar Palacios Cisneros, Tamara Pfanner, Tadeja Kuret, Nadja Ižanc, Raphael Micheroli, Joaquim Polido-Pereira, Fernando Saraiva, Swathi Lingam, Kristina Burki, Blaž Burja, Chantal Pauli, Žiga Rotar, Matija Tomšič, Saša Čučnik, João Eurico Fonseca, Oliver Distler, Ângelo Calado, Vasco C. Romão, Caroline Ospelt, Snežna Sodin-Semrl, Mark D. Robinson, Mojca Frank Bertoncelj   +26 more
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Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment

Scientific Reports, 2023
Programmed cell death protein 1 (PD-1)-expressing T cells are expanded in individuals with established rheumatoid arthritis (RA). However, little is known about their functional role in the pathogenesis of early RA.
Katie Lowe, Annabelle Small, Qingxuan Song, Ling-Yang Hao, William Murray-Brown, Susanna Proudman, Malcolm D. Smith, Sunil Nagpal, Mihir D. Wechalekar   +8 more
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Ultrasound-Guided Synovial Biopsy: A Review

Frontiers in Medicine, 2021
Ultrasound-guided synovial biopsy is a safe, well-tolerated, and effective method to collect good-quality synovial tissue from all types of joints for clinical and research purposes. Although synovial biopsy cannot be used to distinguish between types of
Fernando Saraiva, Fernando Saraiva
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Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis

Scientific Reports, 2021
Prokineticin 2 (PK2) is a secreted protein involved in several pathological and physiological processes, including the regulation of inflammation, sickness behaviors, and circadian rhythms.
Kentaro Noda, Bianca Dufner, Haruyasu Ito, Ken Yoshida, Gianfranco Balboni, Rainer H. Straub   +5 more
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