Results 161 to 170 of about 2,054,522 (273)

Ordered assembly of Cas12a for better performance of CRISPR/Cas system with application to the diagnosis of dental caries

Interdisciplinary Medicine, EarlyView.
Here, we present a tetrahedral DNA framework (TDF)‐mediated Cas12a ordered assembly strategy. TDFs arrange CRISPR/Cas12a into ordered structures controllably, enhancing catalytic efficiency through localized Cas12a hotspots while maintaining spatial intervals to facilitate substrate diffusion.
Yining Zhao, Panpan Qiao, Yujing Zeng, Murtaza Sayed, Qin Mi, Juan Zhang, Genxi Li   +6 more
wiley   +1 more source

PANoptosis-related genes in rheumatoid arthritis synovial tissue: screening, validation, and functional implications. [PDF]

Front Immunol
Lu Y, Yang J, Deng Y, Chen Y, Zhang K, Ouyang L, Zhai Y, He J, Wang C, Huang J, Wang W, Yu H.   +11 more
europepmc   +1 more source

A Pain in the Buttocks: Practice Article for Sonographically Imaging the Quadratus Femoris and Ischiofemoral Impingement

Journal of Clinical Ultrasound, EarlyView.
Hip external rotation can cause compression of the quadratus femoris (QF) between the ischial tuberosity and lesser trochanter of the femur, resulting in pain in the buttock, hip, and groin which can radiate down the leg. Ultrasound imaging can demonstrate dynamic impingement of the QF, including symptom provocation.
Elaine Tyzack, Michelle Fenech
wiley   +1 more source

Targeting inflammatory and angiogenic responses by small-molecule kinase inhibitors in a 3D macrophage-containing spheroid model of rheumatoid arthritis synovial tissue. [PDF]

Arthritis Res Ther
Philippon EML, van Rooijen LJE, Jongejan A, Sims GP, Lee J, Rajasinghe L, van Hamburg JP, van der Laken CJ, Tas SW.   +8 more
europepmc   +1 more source

Artificial intelligence‐assisted nanozyme design for medical and environmental applications

Journal of Intelligent Medicine, EarlyView.
AI‐assisted nanozyme design integrates cross‐source data and machine learning to enable predictive structure‐activity relationships, accelerating intelligent diagnostics, precision therapeutics, and environmental surveillance. Abstract Nanozymes, a class of nanomaterials with intrinsic enzyme‐like catalytic activities, have emerged as promising ...
Xiaolin Guo, Hao Zhang, Zihan Zhao, Qingshan Liu, Jiayi Liu, Jiang Huang, Changlong Liu, Xiaoyu Mu   +7 more
wiley   +1 more source

Low‐Field MRI for Knee Imaging: Current Insights and Evidence From a Systematic Review

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Low‐field magnetic resonance imaging (MRI) has regained interest for musculoskeletal imaging due to advances in magnet design, hardware optimization, and artificial intelligence (AI)–based reconstruction, offering improved accessibility, patient comfort, and sustainability.
Switinder Singh Ghotra, Cláudia dos Sá dos Reis, Allison McGee, Jonathan P. McNulty   +3 more
wiley   +1 more source

Immunohistochemical Expression of TNFR1, IL-6, and TGF-β1 in the Synovial Tissue of Patients with Hip Osteoarthritis. [PDF]

Biomedicines
Todorović P, Jurić I, Kelam N, Rošin M, Čarić D, Boban D, Kopilaš A, Vukojević K.   +7 more
europepmc   +1 more source

Improving Transcriptome Fidelity Following Synovial Tissue Disaggregation. [PDF]

Front Med (Lausanne), 2022
Boyle DL, Prideaux EB, Hillman J, Wang W, Firestein GS.   +4 more
europepmc   +1 more source

Periodontitis and gastric disorders: Systematic review and meta‐analysis of functional dyspepsia and Helicobacter pylori gastritis

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis has been associated with other systemic inflammatory diseases, such as cardiovascular disease, diabetes mellitus, and rheumatoid arthritis; through the translocation of oral bacteria and local inflammatory mediators systemically.
Hadeel Mohammed Abbood, Jasim Mohammed Abbood, Ekin Yay‐Kus, Iain L. C. Chapple   +3 more
wiley   +1 more source

Clinical Applications of 3D Specimen Scanning and Margin Mapping in Musculoskeletal Oncology: A 36 Patient Case Series

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background Text‐based pathology reports inadequately communicate complex three‐dimensional (3D) relationships in musculoskeletal oncology, potentially contributing to errors in re‐resection and adjuvant treatment planning. While our prior 7‐case pilot study established technical feasibility, the scalability of this workflow and its utility as ...
Riley S. Gilbertson, Sakshi Krishna, Joaquin Austerlitz, Andreja Radevic, Michael J. Colello, Alexander N. Perez, Reena Singh, Jennifer L. Halpern, Herbert S. Schwartz, Michael C. Topf, Joshua M. Lawrenz, Daniel J. Johnson   +11 more
wiley   +1 more source