Results 91 to 100 of about 58,561 (288)
A cartilage catabolic factor from synovium [PDF]
Biochemical Journal, 1979 Porcine synovium in organ culture produces a factor that causes chondrocytes to degrade their matrix. A quantitative assay for the factor, for which the cartilage of bovine nasal septum is used, is described. Evidence is presented that the catabolic factor is a protein.
J T, Dingle +5 more
openaire +2 more sources
Arthritis &Rheumatology, Accepted Article.Objectives Both susceptibility to, and severity of, rheumatoid arthritis (RA) is associated with the rs26232 C allele. Our primary aim was to identify the biological mechanism underlying this association. Methods Expression of surrounding genes was compared between rs26232 genotypes.
Kevin J. Sheridan +12 more
wiley +1 more source
Synovial tissue macrophages: friend or foe? [PDF]
, 2017 Healthy synovial tissue includes a lining layer of synovial fibroblasts and macrophages. The influx of leucocytes during active rheumatoid arthritis (RA) includes monocytes that differentiate locally into proinflammatory macrophages, and these produce ...
Alivernini, Stefano +1 more
core +2 more sources
Association of Clonal Hematopoiesis with Incident, Late‐Onset, Seropositive Rheumatoid Arthritis
Arthritis &Rheumatology, Accepted Article.Objectives Clonal hematopoiesis (CH), defined by acquired driver mutations in hematopoietic stem cells, is associated with many inflammatory diseases of aging. We investigated whether CH and its subtypes, clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alteration (mCA), are associated with incident rheumatoid arthritis (RA)
Kun Zhao +8 more
wiley +1 more source
Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis. [PDF]
, 2019 How pathogenic cluster of differentiation 4 (CD4) T cells in rheumatoid arthritis (RA) develop remains poorly understood. We used Nur77-a marker of T cell antigen receptor (TCR) signaling-to identify antigen-activated CD4 T cells in the SKG mouse model ...
Ashouri, Judith F +10 more
core
Inflammatory cytokines and mechanical injury induce post-traumatic osteoarthritis-like changes in a human cartilage-bone-synovium microphysiological system [PDF]
, 2022 Garima Dwivedi +9 more
openalex +1 more source
BMEMat, EarlyView.The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang +6 more
wiley +1 more source
The role of epidermal growth factor-like module containing mucin-like hormone receptor 2 in human cancers. [PDF]
, 2014 G-protein coupled receptors (GPCRs) are among the most diverse and ubiquitous proteins in all of biology. The epidermal growth factor-seven span transmembrane (EGF-TM7) subfamily of adhesion GPCRs is a small subset whose members are mainly expressed on ...
Bloch, Orin +8 more
core +2 more sources
Atomically precise metal cluster enzymes for pathological tissue regeneration
BMEMat, EarlyView.Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong +11 more
wiley +1 more source
International Journal of General Medicine, 2021 Shuo Zhang,1 Genxiang Rong,2 Yayun Xu,3 Juehua Jing1 1Department of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China; 2Department of Orthopedics, The First Affiliated Hospital of Anhui Medical ...
Zhang S, Rong G, Xu Y, Jing J
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