Results 51 to 60 of about 58,561 (288)

A Synovium‐on‐Chip Platform to Study Multicellular Interactions in Arthritis

Advanced Healthcare Materials, EarlyView.
The Synovium‐on‐Chip comprises a thin microporous PDMS membrane to support co‐culture of fibroblast‐like synoviocytes (FLS), THP‐1‐derived macrophages, and endothelial cells, enabling real‐time analysis of synovial‐vascular interactions. FLS migration through the pores drives endothelial remodeling, while TNF‐α stimulation induces robust inflammatory ...
Laurens R. Spoelstra, Fleur R. Semmekrot, Nuno Araújo‐Gomes, Daniël Wijnperle, Monique M. A. Helsen, Martijn H.J. Van Den Bosch, Loes. I. Segerink, Séverine Le Gac, Marcel Karperien   +8 more
wiley   +1 more source

High levels of TDO2 in relation to pro-inflammatory cytokines in synovium and synovial fluid of patients with osteoarthritis

BMC Musculoskeletal Disorders, 2022
Background Tryptophan 2,3-dioxygenase (TDO2) is the primary enzyme that catabolizes tryptophan to kynurenine. Numerous studies have suggested that TDO2 is involved in inflammation-related diseases.
Genxiang Rong, Tao Zhang, Yayun Xu, Zhenyu Zhang, Binjie Gui, Kongzu Hu, Jinling Zhang, Zhi Tang, Cailiang Shen   +8 more
doaj   +1 more source

Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early Rheumatoid Arthritis: an observational study. [PDF]

, 2015
INTRODUCTION: Neovascularization contributes to the development of sustained synovial inflammation in the early stages of Rheumatoid Arthritis. Ultrasound (US) provides an indirect method of assessing synovial blood flow and has been shown to correlate ...
AE Koch, AE Koch, Alessandra Marrelli, Arti Mahto, AW Mould, Costantino Pitzalis, Debasish Pyne, E Bodolay, Frances Humby, J Holash, J Holash, K Polzer, Lu Zou, M Andersen, M Raica, M Walther, M Walther, Maria DiCicco, Michele Bombardieri, Nora Ng, P Haiko, PP Tak, Rebecca E Hands, S Kelly, S Lee, Stephen Kelly, Sudeh Riahi, U Fiocco, U Fiocco, V Krenn, WA Schmidt, Y Jing, Y Xu, Z Szekanecz   +33 more
core   +2 more sources

Hydrogel Confinement Strategies for 3D Cell Culture in Microfluidic Systems

Advanced Materials Technologies, EarlyView.
Hydrogel confinement structures are key to organizing 3D cell cultures in microfluidic devices. This review classifies five structural strategies (micropillar, phaseguide, porous membrane, stepped‐height, and support‐free) and examines their trade‐offs alongside fabrication methods.
Soohyun Kim, Min Seok Lee, Sung Kyun Lee
wiley   +1 more source

Effects of Diet Induced Weight Reduction on Cartilage Pathology and Inflammatory Mediators in the Joint Tissues

Frontiers in Medicine, 2021
Obesogenic diets contribute to the pathology of osteoarthritis (OA) by altering systemic and local metabolic inflammation. Yet, it remains unclear how quickly and reproducibly the body responds to weight loss strategies and improve OA.
Antonia RuJia Sun, Antonia RuJia Sun, Xiaoxin Wu, Xiaoxin Wu, Ross Crawford, Ross Crawford, Hongxing Li, Lin Mei, Yong Luo, Yin Xiao, Yin Xiao, Xinzhan Mao, Indira Prasadam   +12 more
doaj   +1 more source

Mesenchymal stem cells for management of rheumatoid arthritis : immune modulation, repair or both? [PDF]

, 2018
The authors are grateful for support to their research from Arthritis Research UK (grants 19271, 19429, 19667, 20050, 20775) and the Medical Research Council (grant no.
Ansboro, Sharon, de Bari, Cosimo, Roelofs, Anke J.   +2 more
core   +1 more source

PM10 Impairs CD56dim NK Cell Cytotoxicity via FNBP1 Suppression to Exacerbate Rheumatoid Arthritis: Insights from Multimodal Multi‐Omics

Advanced Science, EarlyView.
This study, through multi‐omics approaches and animal models, revealed that air pollutant PM10 exacerbates the progression of rheumatoid arthritis (RA) by suppressing FNBP1 expression and impairing the cytotoxic function of CD56dim NK cells. The “PM10–FNBP1–NK cells” axis provided novel insights into the environmental pathogenesis of RA and suggested ...
Runhan Zhao, Qinyang Zhang, Yu Jiang, Dagang Tang, Xiao Qu, Jun Zhang, Yi Chen, Weixia Duan, Tao Li, Zhengwei Cai, Yanran Huang, Xiaoji Luo   +11 more
wiley   +1 more source

Short-term overloading exercise attenuates articular chondrocyte features partly via synovium–cartilage interactions mediated by inhibin subunit beta A

Scientific Reports
Excessive mechanical loading leads to cartilage degeneration. However, short-term responses of the synovium and cartilage to overloading and interactions between these tissues remain poorly understood.
Yusuke Arino, Asuka Terashima, Toshiya Tsubaki, Yasuhide Iwanaga, Yasunori Omata, Sakae Tanaka, Taku Saito   +6 more
doaj   +1 more source

Fibroblasts in rheumatoid arthritis: novel roles in joint inflammation and beyond

Frontiers in Medicine
High-throughput technologies in human and animal studies have revealed novel molecular and cellular pathways involved in tissue inflammation of rheumatoid arthritis (RA).
Elpida Neofotistou-Themeli, Elpida Neofotistou-Themeli, Panagiota Goutakoli, Panagiota Goutakoli, Theodoros Chanis, Theodoros Chanis, Maria Semitekolou, Maria Semitekolou, Eirini Sevdali, Eirini Sevdali, Prodromos Sidiropoulos, Prodromos Sidiropoulos   +11 more
doaj   +1 more source

Extra-articular synovial chondromatosis of the ankle: Unusual case with radiologic-pathologic correlation. [PDF]

, 2020
Extra-articular synovial chondromatosis is a rare entity in the foot and ankle. We present a case of a 49-year-old female who presented for evaluation of a palpable concern following trauma; which was found to represent synovial chondromatosis. This case
Abraham, John, Dheer, Sachin, Jiang, Wei, Karanjia, Homyar, Schick, Faith, Sullivan, Paul E, Taweel, Nicholas   +6 more
core   +1 more source