Results 91 to 100 of about 7,229,609 (313)

The Materials Science Procedural Text Corpus: Annotating Materials Synthesis Procedures with Shallow Semantic Structures [PDF]

arXiv, 2019
Materials science literature contains millions of materials synthesis procedures described in unstructured natural language text. Large-scale analysis of these synthesis procedures would facilitate deeper scientific understanding of materials synthesis and enable automated synthesis planning. Such analysis requires extracting structured representations
arxiv  

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

LTLf Synthesis with Fairness and Stability Assumptions [PDF]

arXiv, 2019
In synthesis, assumptions are constraints on the environment that rule out certain environment behaviors. A key observation here is that even if we consider systems with LTLf goals on finite traces, environment assumptions need to be expressed over infinite traces, since accomplishing the agent goals may require an unbounded number of environment ...
arxiv  

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

Molecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen, Pieter‐Jan Volders, Ellen Geerdens, Severine Berden, Joni Van der Meulen, Aaron De Cock, Stefanie Vermeire, Jacques Van Huysse, Marie de Barsy, Gabriela Beniuga, Wendy W. J. de Leng, Anne M. L. Jansen, Imke Demers, Zeliha Ozgur, Hendrikus Jan Dubbink, Ernst‐Jan M. Speel, Wilfred F. J. van IJcken, Brigitte Maes   +17 more
wiley   +1 more source

State of the Data: Assessing the FAIRness of US Geological Survey Data

Data Science Journal
In response to recent shifts towards open science that emphasize transparency, reproducibility, and access to research data, the US Geological Survey (USGS) conducted a study to assess the degree to which USGS data assets meet the FAIR data principles ...
Vivian B. Hutchison, Tamar Norkin, Lisa S. Zolly, Leslie Hsu   +3 more
doaj   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

RESEARCHES ON PYRIMIDINES: SYNTHESIS OF URACIL-4-ACETIC ACID. [PDF]

, 1908
Henry L. Wheeler, Leonard M. Liddle
openalex   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Synthesis of Infinite State Systems [PDF]

arXiv
The classical Church synthesis problem, solved by Buchi and Landweber, treats the synthesis of finite state systems. The synthesis of infinite state systems, on the other hand, has only been investigated few times since then, with no complete or systematic solution. We present a systematic study of the synthesis of infinite state systems.
arxiv  

THE SYNTHESIS OF CERTAIN SUBSTITUTED PYROGALLOL ETHERS, INCLUDING A NEW ACETOPHENETIDE DERIVED FROM THE ETHYL ETHER OF SYRINGIC ACID.¹ [PDF]

, 1919
Marston Taylor Bogert, J Ehrlich
openalex   +1 more source