Results 91 to 100 of about 2,561,314 (269)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Metal-Organic Chemical Vapor Deposition in a Transmission Electron Microscope [PDF]

BIO Web of Conferences
Jacobsson Daniel, Tornberg Marcus, Maliakkal Carina B., Wallenberg Reine, Dick Kimberly A.   +4 more
doaj   +1 more source

Entry to 2-aminoprolines via electrochemical decarboxylative amidation of N‑acetylamino malonic acid monoesters

Beilstein Journal of Organic Chemistry
The electrochemical synthesis of 2-aminoprolines based on anodic decarboxylation–intramolecular amidation of readily available N-acetylamino malonic acid monoesters is reported. The decarboxylative amidation under Hofer–Moest reaction conditions proceeds
Olesja Koleda, Janis Sadauskis, Darja Antonenko, Edvards Janis Treijs, Raivis Davis Steberis, Edgars Suna   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Three-dimensional covalent organic frameworks with nia nets for efficient separation of benzene/cyclohexane mixtures

Nature Communications
The synthesis of three-dimensional covalent organic frameworks with highly connected building blocks presents a significant challenge. In this study, we report two 3D COFs with the nia topology, named JUC-641 and JUC-642, by introducing planar hexagonal ...
Jianhong Chang, Fengqian Chen, Hui Li, Jinquan Suo, Haorui Zheng, Jie Zhang, Zitao Wang, Liangkui Zhu, Valentin Valtchev, Shilun Qiu, Qianrong Fang   +10 more
doaj   +1 more source

Copper(II) complexes with fluorinated 5-aryl-2,2’-bipyridine-6(6’)-carboxylic acid tridentate ligands

Chimica Techno Acta
Three Cu(II) complexes containing (poly)fluorine ligands based on 5-aryl-2,2’-bipyridine-6(6’)-carboxylic acids have been synthesized for the first time. These complexes belong to either triclinic (P-1) or orthorhombic (Iba2) crystal systems. The packing
Timofey D. Moseev, Mikhail V. Varaksin, Alexey P. Krinochkin, Maria A. Valieva, Ekaterina A. Kudryashova, Yulia M. Sayfutdinova, Anastasiya V. Rybakova, Dmitry S. Kopchuk, Grigory V. Zyryanov, Youcef Ballou, Pavel A. Slepukhin, Vasiliy S. Gaviko, Valery N. Charushin, Oleg N. Chupakhin   +13 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Growth of Au-seeded GaAs-GaSb nanowires explored in environmental TEM [PDF]

BIO Web of Conferences
Marnauza Mikelis, Sjökvist Robin, Kraina Azemina, Jacobsson Daniel, Dick-Thelander Kimberly   +4 more
doaj   +1 more source

Formal synthesis of (-)-warburganal and synthesis of (+)-isodrimenin

Natural Product Research
The formal divergent synthesis of natural products (−)-warburganal and synthesis of (+)-isodrimenin has been developed from α-hydroxy β,γ-unsaturated aldehyde I, which was easily prepared from available (+)-sclareolide in 5 steps. Reduction of intermediate I to II via an aldehyde reduction provides a 10-step access to (−)-warburganal, while oxidation ...
Xian-Hui Zhao, Liang Zhao, Yue-Cheng Wu, Ya-Jing Bian, Hui-Jing Li, Yan-Chao Wu   +5 more
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source