Results 281 to 290 of about 12,982,812 (373)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

A 2nd-generation scalable synthesis of the HIV-1 entry inhibitor CJF-III-288 enabled by photoredox catalysis.

Chem Commun (Camb)
Nadraws JW, Pokle MS, Smith AB.
europepmc   +1 more source

METTL14 Promotes Lipid Synthesis in Dairy Goat Mammary Epithelial Cells by Targeting <i>CEBPB</i> via m6A-YTHDF1/3-Dependent Manner. [PDF]

Animals (Basel)
Jiao H, Zhu L, Tang X, Gong P, Wang W, Liu B, Luo J.   +6 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Unveiling Resveratrone: A High-Performance Antioxidant Substance. [PDF]

Antioxidants (Basel)
Lim E, Gil KE, Park KC.
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Methods of Engaging Interest-Holders in Healthcare Evidence Syntheses: A Scoping Review. [PDF]

Cochrane Evid Synth Methods
Todhunter-Brown A, Petkovic J, Chang C, Griebler U, Hannigan A, Hilgart J, Hussain B, Jull J, Koscher-Kien C, Ledinger D, Nussbaumer-Streit B, Oloyede O, Tomlinson E, Dawson S, Dewidar O, Grant S, Lytvyn L, Concannon TW, Dans L, John D, Jordan Z, Mayo-Wilson E, McCutcheon C, Nonino F, Pollock D, April KT, Campbell P, Khabsa J, Magwood O, Welch V, Tugwell P.   +30 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

A new synthesis of Tyrian purple (6,6'-dibromoindigo) and its corresponding sulfonate salts. [PDF]

Beilstein J Org Chem
Helmers H, Horton M, Concepcion J, Bjorklund J, Boaz NC.   +4 more
europepmc   +1 more source