Results 31 to 40 of about 2,945,450 (227)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Synthetic retina for AER systems development [PDF]

open access: yes, 2009
Neuromorphic engineering tries to mimic biology in information processing. Address-Event Representation (AER) is a neuromorphic communication protocol for spiking neurons between different layers.
Civit Balcells, Antón   +4 more
core  

Use of Medicinal Cannabis and Synthetic Cannabinoids in Posttraumatic Stress Disorder (PTSD): a systematic review [PDF]

open access: yes, 2019
Background and Objectives: Post-traumatic stress disorder (PTSD) is a common psychiatric disorder resulting from a traumatic event, is manifested through hyperarousal, anxiety, depressive symptoms, and sleep disturbances.
Chiappini, Stefania   +6 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Synthetic generation of address-events for real-time image processing [PDF]

open access: yes, 2003
Address-event-representation (AER) is a communication protocol that emulates the nervous system's neurons communication, and that is typically used for transferring images between chips.
Civit Balcells, Antón   +5 more
core  

Social context prevents heat hormetic effects against mutagens during fish development

open access: yesFEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere   +5 more
wiley   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

open access: yesFEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan   +10 more
wiley   +1 more source

Synthetic dimensions in ultracold molecules: quantum strings and membranes

open access: yes, 2018
Synthetic dimensions alter one of the most fundamental properties in nature, the dimension of space. They allow, for example, a real three-dimensional system to act as effectively four-dimensional.
Gadway, Bryce   +2 more
core   +2 more sources

Synthetic cathinones related fatalities: an update [PDF]

open access: yes, 2018
Synthetic cathinones, more commonly known as "bath salts", are synthetic drugs chemically related to cathinone, a psychostimulant found in the khat plant.
Busardò, F. P.   +5 more
core   +1 more source

A Synthetic Capillary [PDF]

open access: yesBiophysical Journal, 2013
Tissue engineering strives to create functional tissue for organ replacement and regenerative medicine by combining living cells with a porous scaffold that promote growth and differentiation. Recent attempts to replace tissue with autologous cells on a biodegradable scaffold have been frustrated by inflammatory and healing responses. We speculate that
Gregory Timp   +3 more
openaire   +2 more sources

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