Results 101 to 110 of about 2,829,869 (398)

The impact of synthetic biology in chemical engineering - Educational issues [PDF]

, 2012
This paper describes the development of syntheticbiology as a distinct entity from current industrial biotechnology and the implications for a future based on its concepts.
Hall, George M., Howe, Joe
core   +1 more source

Biological Materials: The Next Frontier for Cell-Free Synthetic Biology

Frontiers in Bioengineering and Biotechnology, 2020
Advancements in cell-free synthetic biology are enabling innovations in sustainable biomanufacturing, that may ultimately shift the global manufacturing paradigm toward localized and ecologically harmonized production processes.
Richard J. R. Kelwick, A. Webb, P. Freemont   +2 more
semanticscholar   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Bottom-up assembly of functional intracellular synthetic organelles by droplet-based microfluidics

, 2020
Bottom-up synthetic biology has directed most efforts toward the construction of artificial compartmentalized systems that recreate living cell functions in their mechanical, morphological, or metabolic characteristics.
Platzman, I., Schröter, M., Spatz, J., Staufer, O.   +3 more
core   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

A noncanonical role of roX RNAs in autosomal epigenetic repression

Nature Communications
Long noncoding RNAs known as roX (RNA on the X) are crucial for male development in Drosophila, as their loss leads to male lethality from the late larval stages.
Jianjian Li, Shuyang Xu, Zicong Liu, Liuyi Yang, Zhe Ming, Rui Zhang, Wenjuan Zhao, Huipai Peng, Jeffrey J. Quinn, Manyin Wu, Yushan Geng, Yuying Zhang, Jiazhi He, Minghai Chen, Nan Li, Ning-Yi Shao, Qing Ma   +16 more
doaj   +1 more source

Eukaryotic Systems Broaden the Scope of Synthetic Biology [PDF]

, 2011
Synthetic biology aims to engineer novel cellular functions by assembling well-characterized molecular parts (i.e., nucleic acids and proteins) into biological “devices” that exhibit predictable behavior. Recently, efforts in eukaryotic synthetic biology
Haynes, Karmella A., Silver, Pamela
core   +1 more source

Engineering Bacterial Cellulose by Synthetic Biology

International Journal of Molecular Sciences, 2020
Synthetic biology is an advanced form of genetic manipulation that applies the principles of modularity and engineering design to reprogram cells by changing their DNA.
Amritpal S. Singh, Kenneth T. Walker, R. Ledesma‐Amaro, T. Ellis   +3 more
semanticscholar   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Misconceptions of Synthetic Biology: Lessons from an Interdisciplinary Summer School [PDF]

, 2016
In 2014, an international group of scholars from various fields analysed the "societal dimensions" of synthetic biology in an interdisciplinary summer school. Here, we report and discuss the biologists' observations on the general perception of synthetic
Acevedo-Rocha, Carlos G., Chizzolini, Fabio, Rothschild, Lynn J., Verseux, Cyprien   +3 more
core   +2 more sources