Results 181 to 190 of about 2,952,613 (401)

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Author Correction: Inducible expression of large gRNA arrays for multiplexed CRISPRai applications

Nature Communications, 2023
William M. Shaw, Lucie Studená, Kyler Roy, Piotr Hapeta, Nicholas S. McCarty, Alicia E. Graham, Tom Ellis, Rodrigo Ledesma-Amaro   +7 more
doaj   +1 more source

An Engineered Probiotic Consortium Based on Quorum‐Sensing for Colorectal Cancer Immunotherapy

Advanced Science
Recent progress in synthetic biology has empowered engineered probiotics to sense tumor‐specific physicochemical signals, thereby facilitating targeted in situ drug delivery.
Yufei Guo, Mengxue Gao, Lina Wang, Haibin Yuan, Jianan Yin, Jiahao Wu, Xinran Gao, Zhixin Zhu, Yan Zhang, Zichen Wang, He Huang, Guangbo Kang   +11 more
doaj   +1 more source

Diversity-Oriented Synthetic Strategies Applied to Cancer Chemical Biology and Drug Discovery [PDF]

, 2014
Ian Collins, Alan M. Jones
openalex   +1 more source

Phylogeny-Informed Synthetic Biology Reveals Unprecedented Structural Novelty in Type V Glycopeptide Antibiotics

, 2022
Min Xu, Wenliang Wang, Nicholas Waglechner, Elizabeth Culp, Allison K. Guitor, Gerard D. Wright   +5 more
openalex   +1 more source

Synthetic biology—putting engineering into biology [PDF]

, 2017
Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we ...
Heinemann, Matthias, Panke, Sven
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Applications of Synthetic Biology in Microbial Biotechnology [PDF]

, 2010
Hal S. Alper, Patrick C. Cirino, Elke Nevoigt, Ganesh Sriram   +3 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Delaying production with prokaryotic inducible expression systems

Microbial Cell Factories
Background Engineering bacteria with the purpose of optimizing the production of interesting molecules often leads to a decrease in growth due to metabolic burden or toxicity.
Jasmine De Baets, Brecht De Paepe, Marjan De Mey   +2 more
doaj   +1 more source