Results 31 to 40 of about 13,623 (265)

Synthetic cannabinoids in the kidneys [PDF]

Revista da Associação Médica Brasileira, 2017
Acute kidney injury is an important cause of mortality and morbidity today and can occur due to several reasons. As time, geographic regions, and living conditions change, various etiological agents arise with nephrotoxic effects. Awareness of such nephrotoxic effects has been raised with the increasing frequency of addictive substance use, especially ...
Alp, Alper, Akdam, Hakan, Avcıoğlu, Banu Yılmaz, Ersan, Sibel   +3 more
openaire   +3 more sources

Clinical and Forensic Toxicological Aspects of Synthetic Cannabinoids: A Review and Update [PDF]

Asia Pacific Journal of Medical Toxicology, 2020
Background: Synthetic cannabinoids (SCs) are highly abused of New Psychoactive Substances (NPS). SCs has known under street names such as “Spice”, “herbal incense” and “K2”, act as endocannabinoids (CB) receptor full agonists and have unpredictable ...
Kambiz Soltaninejad
doaj   +1 more source

Broadly Neutralizing Synthetic Cannabinoid Vaccines [PDF]

JACS Au, 2020
Synthetic cannabinoids (SCs) constitute a significant portion of psychoactive substances forming a major public health risk. Due to the wide variety of SCs, broadly neutralizing antibodies generated by active immunization present an intriguing pathway to combat cannabinoid use disorder.
Mingliang Lin, Jinny Claire Lee, Steven Blake, Beverly Ellis, Lisa M. Eubanks, Kim D. Janda   +5 more
openaire   +3 more sources

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Rapid Identification of New Psychoactive Substances in Letters by LA‐APCI‐MS

Drug Testing and Analysis, EarlyView.
Laser ablation coupled to molecular mass spectrometry utilizing a modified atmospheric pressure chemical ionization source was used for the detection of synthetic cannabinoid receptor agonists in infused prison mail samples. ABSTRACT New psychoactive substances (NPS), especially synthetic cannabinoid receptor agonists (SCRA), are increasingly smuggled ...
Mark Wesner, Hannah Rämisch, Laura Besch, Johannes Schmeinck, Uwe Karst   +4 more
wiley   +1 more source

Synthetic Cannabinoids in Oral Fluid [PDF]

Journal of Analytical Toxicology, 2011
At the end of 2010, the U.S. Drug Enforcement Administration (DEA) used its emergency scheduling authority to temporarily control five chemicals, JWH-018, JWH-073, JWH-200, CP-47497, and cannabicyclohexanol (CP-47497 C8), often referred to as "Spice", K2, or "synthetic cannabinoids" because of their reported cannabis-like effects.
Cynthia, Coulter, Margaux, Garnier, Christine, Moore   +2 more
openaire   +2 more sources

Simulation of the Metabolism of New Psychoactive Substances Using Electrochemistry‐Mass Spectrometry: Introducing an Innovative Software Tool for Rapid Data Evaluation

Drug Testing and Analysis, EarlyView.
A novel software tool for the rapid and efficient simulation of the metabolism of new psychoactive substances was developed and applied to mimic the metabolism of the synthetic cannabinoid receptor agonist MDMB‐4en‐PINACA. ABSTRACT An innovative software tool for the rapid and efficient simulation of the metabolism of new psychoactive substances (NPS ...
Mark Wesner, Steffen Heuckeroth, Michael Pütz, Uwe Karst   +3 more
wiley   +1 more source

Deaths linked to synthetic cannabinoids [PDF]

Forensic Science, Medicine, and Pathology, 2015
Over the last 5 years there has been an influx of novel designer drugs (mostly illegal) which are intended to mimic the effects of cannabis (synthetic cannabinoids). Many of these compounds are created by research groups attempting to find an analog of cannabis that can be used therapeutically to treat pain and other conditions.
Dimitri, Gerostamoulos, Olaf H, Drummer, Noel W, Woodford   +2 more
openaire   +2 more sources

Identification and Structural Elucidation of a New Synthetic Cannabinoid, MDMB‐5′Br‐PINACA, in Seized Herbal Materials

Drug Testing and Analysis, EarlyView.
MDMB‐5Br‐PINACA, a novel synthetic cannabinoid, was identified and structurally characterized in seized herbal products using GC‐MS, LC‐HRMS, and NMR. The discovery underscores ongoing diversification of SCs and the need for vigilant surveillance.
Alexandre Barcia de Godoi, Lucas André Zeoly, Rafael Lanaro, Ingrid Simões Oliveira, Mariana Cepollaro Diana, Mauricio Yonamine, Jose Luiz Costa   +6 more
wiley   +1 more source

Cannabinoids in traumatic brain injury and related neuropathologies: preclinical and clinical research on endogenous, plant-derived, and synthetic compounds

Journal of Neuroinflammation, 2023
Traumatic brain injury is common, and often results in debilitating consequences. Even mild traumatic brain injury leaves approximately 20% of patients with symptoms that persist for months.
Brittney R. Lins, Chidozie C. Anyaegbu, Sarah C. Hellewell, Melissa Papini, Terence McGonigle, Luca De Prato, Matthew Shales, Melinda Fitzgerald   +7 more
doaj   +1 more source