Results 31 to 40 of about 11,438 (231)

The Use of Synthetic Cannabinoids among Youths and Related Factors

Addicta: The Turkish Journal on Addictions, 2017
This research was carried out to obtain in-depth knowledge about the sociodemographic characteristics of young people who are using synthetic cannabinoids, the reasons for this use, and what they experience afterwards.
Derya Adıbelli, Selvinaz Saçan
doaj   +1 more source

Emergency Physicians' Knowledge of Cannabinoid Designer Drugs

Western Journal of Emergency Medicine, 2013
Introduction: The use of synthetic drugs of abuse in the United States has grown in the last few years, with little information available on how much physicians know about these drugs and how they are treating patients using them.
Patrick M Lank, Elizabeth Pines, Mark B Mycyk   +2 more
doaj   +1 more source

Rapid Detection of Synthetic Cannabinoids in E-Cigarette Liquids Based on Miniature Ion Trap Mass Spectrometry

Zhipu Xuebao
In recent years, the misuse of synthetic cannabinoids has garnered significant societal attention. To evade regulation, synthetic cannabinoids are often illicitly mixed into e-cigarette liquids to create "heady e-cigarettes".
Ya-jin HE, Hui-wen RUAN, Ming-jian ZHANG, Wu-duo ZHAO, Gui-yun SONG, Ke ZHANG, Bing WANG, Suo-suo YANG, Jian KANG, Bin LI, Shuang WANG, Wei-guo WANG   +11 more
doaj   +1 more source

Synthesis of Six Natural Products Enabled by Selective Hydroxylation of Orcinaldehyde‐Like Substrates With an Enzyme Library

Angewandte Chemie International Edition, EarlyView.
Achieving selective (sp3)C–H hydroxylation can streamline the synthesis of complex organic molecules. Biocatalysis presents an opportunity to realize this transformation, however, identifying useful enzymes that enable synthetic strategies can be a challenge due to limitations in enzyme substrate scope.
Gonzalo J. Villegas Rodríguez, Evan O. Romero, Jonathan C. Perkins, Diego N. Rojas, Maximilian S. Hrigora, Alison R. H. Narayan   +5 more
wiley   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Deaths linked to synthetic cannabinoids [PDF]

Forensic Science, Medicine, and Pathology, 2015
Over the last 5 years there has been an influx of novel designer drugs (mostly illegal) which are intended to mimic the effects of cannabis (synthetic cannabinoids). Many of these compounds are created by research groups attempting to find an analog of cannabis that can be used therapeutically to treat pain and other conditions.
Dimitri, Gerostamoulos, Olaf H, Drummer, Noel W, Woodford   +2 more
openaire   +2 more sources

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

Investigation of the In Vitro and In Vivo Metabolism and μ‐Opioid Receptor Affinity of the Nitazene N‐Pyrrolidino Fluetonitazene

Drug Testing and Analysis, EarlyView.
Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp, Gaia Alluisetti, Wolfgang Weinmann, Bettina Schrag, Frank Sporkert, Maurine Leclerc, Katharina Elisabeth Grafinger   +6 more
wiley   +1 more source

Synthetic cannabinoids impact on cognitive functions

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2023
Background Synthetic cannabinoids SC are now becoming progressively popular among young people worldwide; little is known about their negative effects.
Hanan Hany Elrassas, Yasser Abdel Razek Elsayed, Mai SeifElDin Abdeen, Aya Taha Mohamed, Zeinab Mohamed El Nagar   +4 more
doaj   +1 more source

Phase I Metabolism of Novel Phencyclidine Derivative 3‐Cl‐PCP: In Vitro Studies With Pooled Human Liver Microsomes and Investigation of a Post‐Mortem Case

Drug Testing and Analysis, EarlyView.
A fatal 3‐chloro‐phencyclidine (3‐Cl‐PCP) intoxication was investigated by analyzing postmortem samples and a pooled human liver microsomes assay. Tentative metabolite identification was performed by liquid chromatography‐quadrupole time‐of‐flight mass spectrometry (LC‐QTOF‐MS). Seven phase I metabolites were identified.
Johannes Kutzler, Tobias Veit, Thomas Keller, Volker Auwärter   +3 more
wiley   +1 more source