Results 1 to 10 of about 13,423 (179)

AB‐MDMSBA—Not a Synthetic Cannabinoid Receptor Agonist [PDF]

Pharmacology Research & Perspectives
Synthetic cannabinoids remain one of the most prominent classes of New Psychoactive Substances (NPS). The introduction of “blanket bans” has only invigorated the development and emergence of novel compounds. Recently, a putative synthetic cannabinoid, AB‐
Monica Patel, Dharshini Ganeshan, Izzy Horgan, Hannah Partington, Michelle Glass   +4 more
doaj   +3 more sources

Region-Specific Impact of Repeated Synthetic Cannabinoid Exposure and Withdrawal on Endocannabinoid Signaling, Gliosis, and Inflammatory Markers in the Prefrontal Cortex and Hippocampus [PDF]

Biomolecules
Synthetic cannabinoid use raises concerns about its neuroinflammatory effects, including molecular adaptations of the endocannabinoid system (ECS) in the brain.
Evelin Vadas, Antonio J. López-Gambero, Antonio Vargas, Miguel Rodríguez-Pozo, Patricia Rivera, Juan Decara, Antonia Serrano, Stella Martín-de-las-Heras, Fernando Rodríguez de Fonseca, Juan Suárez   +9 more
doaj   +2 more sources

Brodifacoum contamination of synthetic cannabinoid causing unexplained coagulopathy in multiple trauma: A case report [PDF]

Trauma Case Reports
An 18-year-old female presented to the emergency department after a motor vehicle collision. Initial imaging revealed a liver laceration. Subsequent labs showed significantly elevated prothrombin time, international normalized ratio, and activated ...
Anthony V. Thomas, Mackenzie L. Johnson, Anna M. Tincher, Saniya Zackariya, Hassaan A. Khan, Uzma Rizvi, Scott G. Thomas, Timothy W. Noveroske, Daniel H. Fulkerson, Ernest E. Moore, Mark M. Walsh   +10 more
doaj   +2 more sources

Long-term consequences of adolescent exposure to the synthetic cannabinoid AB-FUBINACA in male and female mice [PDF]

iScience
Summary: The consumption of synthetic cannabinoids during adolescence is reported to be a risk factor for the appearance of psychiatric disorders later in life.
Cristina Izquierdo-Luengo, María Ponce-Renilla, Marc Ten-Blanco, María Andrea Arnanz, Rosa María Tolón, Inmaculada Pereda-Pérez, Fernando Berrendero   +6 more
doaj   +2 more sources

Identification of Synthetic Cannabinoid 5F-EDMB-PICA in Suspicious Herbal Products [PDF]

Fayixue Zazhi, 2021
Objective To study the qualitative analysis strategy for unknown synthetic cannabinoid in the suspicious herbal product when no reference substance is available. Methods The synthetic cannabinoid in herbal blend was extracted with methanol.
MENG Xin, HUA Zhen-dong, JIA Wei, at al.
doaj   +1 more source

Occurrence of Takotsubo Cardiomyopathy after Synthetic Cannabinoid Consumption [PDF]

Addiction and Health, 2019
Background: Synthetic cannabinoid use such as “K2” and “Spice” is popular secondary to its inability to be detected in a urine drug screen. It is associated with a wide range of myocardial pathologies including obstructive and non-obstructive coronary ...
Denelle Mohammed
doaj   +1 more source

Acute Kidney Injury (AKI) in Young Synthetic Cannabinoids Abusers

Biomedicines, 2022
Background. Synthetic cannabinoid-related acute kidney injury represents an increasingly important public health issue due to the diagnostic challenges given by low clinical suspicion of the disease and the frequent undetectability in routine drug tests.
Stefano D’Errico, Martina Zanon, Davide Radaelli, Monica Concato, Martina Padovano, Matteo Scopetti, Paola Frati, Vittorio Fineschi   +7 more
doaj   +1 more source

The Endocannabinoid System Contributes to Electroacupuncture Analgesia

Frontiers in Neuroscience, 2021
The extensive involvement of the endocannabinoid system (ECS) in vital physiological and cognitive processes of the human body has inspired many investigations into the role of the ECS and drugs, and therapies that target this system and its receptors ...
Iona J. MacDonald, Yi-Hung Chen, Yi-Hung Chen, Yi-Hung Chen   +3 more
doaj   +1 more source

Assessment of the effects of CNR1, FAAH and MGLL gene variations on the synthetic cannabinoid use disorder

Türk Biyokimya Dergisi, 2023
Given that drug addiction occurs as a result of complex gene-environment interaction, a number of studies claimed that cannabinoid receptor 1 (CNR1), fatty acid amide hydrolase (FAAH), and monoacylglycerol lipase (MGLL) single nucleotide polymorphisms ...
Altun Beril, Cok Ismet, Noyan Cemal Onur, Kadioglu Ela, Cetin Alptekin, Sengezer Tijen, Altintas Merih, Kurnaz Samet, Dilbaz Nesrin   +8 more
doaj   +1 more source

Effects of cannabinoids on ligand-gated ion channels

Frontiers in Physiology, 2022
Phytocannabinoids such as Δ9-tetrahydrocannabinol and cannabidiol, endocannabinoids such as N-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol, and synthetic cannabinoids such as CP47,497 and JWH-018 constitute major groups of ...
Murat Oz, Keun-Hang Susan Yang, Mohamed Omer Mahgoub   +2 more
doaj   +1 more source