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Current Opinion in Biotechnology, 2001
Synthesis of data into formal models of cellular function is rapidly becoming a necessary industry. The complexity of the interactions among cellular constituents and the quantity of data about these interactions hinders the ability to predict how cells will respond to perturbation and how they can be engineered for industrial or medical purposes ...
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Synthesis of data into formal models of cellular function is rapidly becoming a necessary industry. The complexity of the interactions among cellular constituents and the quantity of data about these interactions hinders the ability to predict how cells will respond to perturbation and how they can be engineered for industrial or medical purposes ...
openaire +2 more sources
Synthetic Cells from Droplet-Based Microfluidics for Biosensing and Biomedical Applications.
SmallSynthetic cells function as biological mimics of natural cells by mimicking salient features of cells such as metabolism, response to stimuli, gene expression, direct metabolism, and high stability.
Kleins Ngocho +7 more
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Cell-Free Expressed Membraneless Organelles Inhibit Translation in Synthetic Cells.
ACS Biomaterials Science & EngineeringCompartments within living cells create specialized microenvironments, allowing multiple reactions to be carried out simultaneously and efficiently. While some organelles are bound by a lipid bilayer, others are formed by liquid-liquid phase separation ...
Abbey O. Robinson +4 more
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Nature, 2010
The “synthetic cell” created by Craig Venter and his colleagues (D. G. Gibson et al. Science doi:10.1126/science.1190719; 2010) is a normal bacterium with a prosthetic genome. As the genome is only about 1% of the dry weight of the cell, only a small part of the cell is synthetic. But the genome is pivotal because it contains the hereditary information
Bedau, Mark +7 more
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The “synthetic cell” created by Craig Venter and his colleagues (D. G. Gibson et al. Science doi:10.1126/science.1190719; 2010) is a normal bacterium with a prosthetic genome. As the genome is only about 1% of the dry weight of the cell, only a small part of the cell is synthetic. But the genome is pivotal because it contains the hereditary information
Bedau, Mark +7 more
openaire +3 more sources
Advanced Healthcare Materials
Microfluidics plays a pivotal role in organ‐on‐chip technologies and in the study of synthetic cells, especially in the development and analysis of artificial cell models. However, approaches that use synthetic cells as integral functional components for
Niki Hakami +5 more
semanticscholar +1 more source
Microfluidics plays a pivotal role in organ‐on‐chip technologies and in the study of synthetic cells, especially in the development and analysis of artificial cell models. However, approaches that use synthetic cells as integral functional components for
Niki Hakami +5 more
semanticscholar +1 more source
Towards applications of synthetic cells in nanotechnology.
Current Opinion in Chemical Biology, 2022Synthetic cells, which are assembled anew from well-defined molecular parts, open-up new possibilities for nanotechnological applications due to their reduced complexity and high functionality.
Daniele Di Iorio, S. Wegner
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A Synthetic Morphogenic Perceptory Cell
SSRN Electronic Journal, 2018We reconstituted a Synthetic Morphogenic Perceptory System (SynMPS) by encapsulating a dynamic cytoskeletal microtubule (MT)-aster together with a light-actuated signaling system in a liposome. SynMPS responds to light with self-organized morphological state transitions that manifest as self-amplifying membrane deformations generated by the MT-aster ...
Gavriljuk, K. +7 more
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Interfacing Synthetic Cells with Biological Cells: An Application of the Synthetic Method
The 2018 Conference on Artificial Life, 2018The “synthetic method” is the methodological approach that guides current scientific attempts of understanding natural processes by the construction of hardware, software, and/or wetware models fro...
Rampioni, G. +4 more
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Synthetic cells and organelles: compartmentalization strategies
BioEssays, 2009AbstractThe recent development of RNA replicating protocells and capsules that enclose complex biosynthetic cascade reactions are encouraging signs that we are gradually getting better at mastering the complexity of biological systems. The road to truly cellular compartments is still very long, but concrete progress is being made.
Roodbeen, R., Hest, J.C.M. van
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Mimicking Adhesion in Minimal Synthetic Cells
Advanced Biosystems, 2019AbstractCell adhesions to the extracellular matrix and to neighboring cells are fundamental to cell behavior and have also been implemented into minimal synthetic cells, which are assembled from molecular building blocks from the bottom‐up. Investigating adhesion in cell mimetic models with reduced complexity provides a better understanding of ...
Solveig M. Bartelt +3 more
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