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Current Opinion in Biotechnology, 2001
Synthesis of data into formal models of cellular function is rapidly becoming a necessary industry. The complexity of the interactions among cellular constituents and the quantity of data about these interactions hinders the ability to predict how cells will respond to perturbation and how they can be engineered for industrial or medical purposes ...
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Synthesis of data into formal models of cellular function is rapidly becoming a necessary industry. The complexity of the interactions among cellular constituents and the quantity of data about these interactions hinders the ability to predict how cells will respond to perturbation and how they can be engineered for industrial or medical purposes ...
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Synthetic Genomics and the Construction of a Synthetic Bacterial Cell
Perspectives in Biology and Medicine, 2012The first synthetic cellular organism was created in 2010 and based on a very small, very simple bacterium called Mycoplasma mycoides . The bacterium was called synthetic because its DNA genome was chemically synthesized rather than replicated from an existing template DNA, as occurs in all other known cellular life on Earth.
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Toward synthetic life: Biomimetic synthetic cell communication
Current Opinion in Chemical Biology, 2021Engineering synthetic minimal cells provide a controllable chassis for studying the biochemical principles of natural life, increasing our understanding of complex biological processes. Recently, synthetic cell engineering has enabled communication between both natural live cells and other synthetic cells.
Abbey O. Robinson +2 more
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Physical Biology, 2018
Abstract How do the cells in our body reconfigure their shape to achieve complex tasks like migration and mitosis, yet maintain their shape in response to forces exerted by, for instance, blood flow and muscle action? Cell shape control is defined by a delicate mechanical balance between active force generation and passive material ...
Yuval Mulla +2 more
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Abstract How do the cells in our body reconfigure their shape to achieve complex tasks like migration and mitosis, yet maintain their shape in response to forces exerted by, for instance, blood flow and muscle action? Cell shape control is defined by a delicate mechanical balance between active force generation and passive material ...
Yuval Mulla +2 more
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Nature, 2010
The “synthetic cell” created by Craig Venter and his colleagues (D. G. Gibson et al. Science doi:10.1126/science.1190719; 2010) is a normal bacterium with a prosthetic genome. As the genome is only about 1% of the dry weight of the cell, only a small part of the cell is synthetic. But the genome is pivotal because it contains the hereditary information
Bedau, Mark +7 more
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The “synthetic cell” created by Craig Venter and his colleagues (D. G. Gibson et al. Science doi:10.1126/science.1190719; 2010) is a normal bacterium with a prosthetic genome. As the genome is only about 1% of the dry weight of the cell, only a small part of the cell is synthetic. But the genome is pivotal because it contains the hereditary information
Bedau, Mark +7 more
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A Synthetic Morphogenic Perceptory Cell
SSRN Electronic Journal, 2018We reconstituted a Synthetic Morphogenic Perceptory System (SynMPS) by encapsulating a dynamic cytoskeletal microtubule (MT)-aster together with a light-actuated signaling system in a liposome. SynMPS responds to light with self-organized morphological state transitions that manifest as self-amplifying membrane deformations generated by the MT-aster ...
Gavriljuk, K. +7 more
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Synthetic biology of cell signaling
Natural Computing, 2015Synthetic biology often takes cues from complex natural networks and pathways to create novel biological systems. The design modalities used in synthetic systems generally follow the different classes of gene regulation in cells such as transcriptional, post-transcriptional and post-translational regulation.
Jonathan Hansen, Yaakov Benenson
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Cell‐Responsive Synthetic Hydrogels
Advanced Materials, 2003Synthetic biomaterial matrices have been formed in the presence of cells by a Michael‐type addition reaction between a difunctional protease substrate peptide, a monofunctional cell adhesion peptide, and a tetrafunctional poly(ethylene glycol). These materials locally degrade in response to cell‐surface proteases, allowing cells to create paths for 3D ...
Lutolf, M. P. +4 more
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Progress Toward Synthetic Cells
Annual Review of Biochemistry, 2014The complexity of even the simplest known life forms makes efforts to synthesize living cells from inanimate components seem like a daunting task. However, recent progress toward the creation of synthetic cells, ranging from simple protocells to artificial cells approaching the complexity of bacteria, suggests that the synthesis of life is now a ...
J Craig, Blain, Jack W, Szostak
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Interfacing Living and Synthetic Cells as an Emerging Frontier in Synthetic Biology
Angewandte Chemie - International Edition, 2021Yuval Elani
exaly