Results 101 to 110 of about 2,867,164 (299)

Recursive construction of perfect DNA molecules from imperfect oligonucleotides

Molecular Systems Biology, 2008
Making faultless complex objects from potentially faulty building blocks is a fundamental challenge in computer engineering, nanotechnology and synthetic biology.
Gregory Linshiz, Tuval Ben Yehezkel, Shai Kaplan, Ilan Gronau, Sivan Ravid, Rivka Adar, Ehud Shapiro   +6 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The DNA helicase Pfh1 promotes fork merging at replication termination sites to ensure genome stability [PDF]

, 2012
Bidirectionally moving DNA replication forks merge at termination sites composed of accidental or programmed DNA-protein barriers. If merging fails, then regions of unreplicated DNA can result in the breakage of DNA during mitosis, which in turn can give
Steinacher, R., Whitby, M. C., Whitby, Matthew C., Steinacher, R, Dalgaard, JZ, Osman, F., Lorenz, Alexander, Whitby, Matthew, Steinacher, Roland, Osman, F, Lorenz, A, Whitby, MC, Lorenz, A., Osman, Fekret, Dalgaard, Jacob Z.   +14 more
core   +1 more source

Ranking ligand affinity for the DNA minor groove by experiment and simulation [PDF]

, 2010
The structural and thermodynamic basis for the strength and selectivity of the interactions of minor-groove binders (MGBs) with DNA is not fully understood.
Wittayanarakul, Kitiyaporn, Parkinson, John A, Hannongbua, Supa, Anthony, Nahoum G., Treesuwan, Witcha, Suckling, Colin J., Khalaf, Abedawn I., Alniss, Hasan, Mackay, Simon P.   +8 more
core   +3 more sources

DNA repair in cancer: emerging targets for personalized therapy

Cancer Management and Research, 2014
Rachel Abbotts, Nicola Thompson, Srinivasan Madhusudan University of Nottingham, Academic Unit of Oncology, Division of Oncology, School of Medicine, Nottingham University Hospitals, City Hospital Campus, Nottingham, UK Abstract: Genomic ...
Abbotts R, Thompson N, Madhusudan S
doaj  

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Independent, Rapid and Targeted Loss of Highly Repetitive DNA in Natural and Synthetic Allopolyploids of Nicotiana tabacum [PDF]

, 2012
PMCID: PMC3351487This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Ales Kovařík, Ales Kovařík (3245892), Michael Chester (164965), Michael Chester, Novák Petr, Petr Novák (2448673), Leitch Andrew R., Andrew R. Leitch (117242), Simon Renny-Byfield, Macas Jiri, Novak, P, Petr Novák, Nichols Richard A., Kovarik, A, Jiri Macas, Renny-Byfield Simon, Jiri Macas (5024513), Simon Renny-Byfield (164962), Nichols, RA, Kovařík Ales, Richard A. Nichols (164968), Macas, J, Chester, M, Renny-Byfield, S, Leitch, AR, Chester Michael, Andrew R Leitch, Richard A Nichols   +27 more
core   +2 more sources

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Modification of cellular DNA by synthetic aziridinomitosenes

Bioorganic & Medicinal Chemistry, 2015
Two synthetic aziridinomitosenes (AZMs), Me-AZM and H-AZM, structurally related to mitomycin C (MC) were evaluated for their anticancer activity against six cancer cell lines (HeLa, Jurkat, T47D, HepG2, HL-60, and HuT-78) and tested for their DNA-modifying abilities in Jurkat cells.
Mallory, Chris M., Carfi, Ryan P., Moon, SangPhil, Cornell, Kenneth A., Warner, Don L.   +4 more
openaire   +4 more sources