Retrospection and prospect of China′ synthetic rubber industry in 2022
, 2023 The change characteristics of production capacity, output, import and export quantity, apparent consumption of main synthetic rubbers of China in 2022 were retrospected, the status of supply and demand of butadiene as well as price changes of main rubber
China Synthetic Rubber Industry Association Secretariat
core +1 more source
ApoE gene therapy: an overview and update [PDF]
, 2005 Atherosclerosis remains the leading cause of death in industrialized societies. Apolipoprotein E (ApoE) is an attractive candidate to treat hypercholesterolemia and coronary heart disease, as it is a circulating protein with pleiotropic ...
Owen, J.S.
core
Beilstein Journal of Organic Chemistry, 2014 Synthetic biologists wishing to self-assemble large DNA (L-DNA) constructs from small DNA fragments made by automated synthesis need fragments that hybridize predictably.
Kevin M. Bradley, Steven A. Benner
doaj +1 more source
The extreme C terminus of herpes simplex virus DNA polymerase is crucial for functional interaction with processivity factor UL42 and for viral replication [PDF]
, 1993 The herpes simplex virus DNA polymerase is composed of two subunits, a large catalytic subunit (Pol) and a smaller subunit (UL42) that increases the processivity of the holoenzyme.
Bebrin, William R +8 more
core
A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei [PDF]
, 1992 Tissue-specific patterns of methylated deoxycytidine residues in the mammalian genome are preserved by postreplicative methylation of newly synthesized DNA. DNA methyltransferase (MTase) is here shown to associate with replication foci during S phase but
Heinz-Ulrich Weier +14 more
core +1 more source
Bioscience Reports, 1994 “Most of the significant work has been summarized in a number of reviews and articles. In these there was, of necessity, a good deal of simplification and omission of detail …. With the passage of time, even 1 find myself accepting such simplified accounts.”
openaire +1 more source
Cooperation of Oligodeoxynucleotides and Synthetic Molecules as Enhanced Immune Modulators
Frontiers in Nutrition, 2019 Unmethylated cytosine–guanine dinucleotide (CpG) motifs are potent stimulators of the host immune response. Cellular recognition of CpG motifs occurs via Toll-like receptor 9 (TLR9), which normally activates immune responses to pathogen-associated ...
Shireen Nigar, Takeshi Shimosato
doaj +1 more source
Synthetic molecular switches driven by DNA-modifying enzymes
Nature CommunicationsTaking inspiration from natural systems, in which molecular switches are ubiquitous in the biochemistry regulatory network, we aim to design and construct synthetic molecular switches driven by DNA-modifying enzymes, such as DNA polymerase and nicking ...
Hong Kang, Yuexuan Yang, Bryan Wei
doaj +1 more source
Polymerase-endonuclease amplification reaction for large-scale enzymatic production of antisense oligonucleotide [PDF]
, 2009 Synthetic oligonucleotides are contaminated with highly homologous failure sequences. Oligonucleotide synthesis is difficult to scale up because it requires expensive equipments, hazardous chemicals, and tedious purification process.
Deming Gou, Xiaolong Wang
core
EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex deficient cancers
Nature CommunicationsExonuclease EXO1 performs multiple roles in DNA replication and DNA damage repair (DDR). However, EXO1 loss is well-tolerated, suggesting the existence of compensatory mechanisms that could be exploited in DDR-deficient cancers.
Marija Maric +17 more
doaj +1 more source