Results 251 to 260 of about 2,867,164 (299)

Purification of synthetic DNA.

Methods in enzymology, 1992
Brown, T, Brown, D
openaire   +2 more sources

Reversible Tuning of Multiple Molecular Kinking for Stem Cell Regulation In Vivo

Advanced Functional Materials, EarlyView.
In this work, we introduce the novel concept of background component‐free “multiple kinks” material platform composed solely of liganded multiple kink‐bearing molecules as a strategy for dynamic biomaterial design. Tri‐kink molecules enable effective near‐infrared light‐triggered ligand masking and visible light‐triggered ligand exposure, thereby ...
Kanghyeon Kim, Jeongah Shin, Chowon Kim, Honghwan Choi, Dahee Kim, Sungkyu Lee, Choongmo Kang, Hyunsik Hong, Taehoon Ha, Nayeon Kang, Jungyeon Rhi, Ramar Thangam, Yuri Kim, Jeongyun Heo, Cheol Hwan Kwak, Jangsun Hwang, Daun Jeong, Rasoul Moradi, Sunghoon Hur, Hyun‐Cheol Song, Hyun‐Do Jung, Min Jae Lee, Rongqin Huang, Pooyan Makvandi, Yun Suk Huh, Ji Hye Choi, Wenguo Cui, Sehoon Kim, Heemin Kang   +28 more
wiley   +1 more source

Biomimetic Core–Shell Liposome Nanoparticles Deplete Lipoproteins and Enhance the Purity of Extracellular Vesicles from Human Blood

Advanced Functional Materials, EarlyView.
Lipoprotein‐mimicking nanoparticles (SL‐NPs), comprising Fe3O4@SiO2 cores coated with liposomal bilayers, selectively capture lipoproteins through protein corona formation. The resulting SL‐NP‐lipoprotein complexes can be removed by low‐speed centrifugation, thereby enhancing the purity of small extracellular vesicles (sEVs) isolated from human serum ...
Man‐Di Wang, Andrew J. Perciaccante, David Inman, Bong Hwan Sung, Alissa M. Weaver, Suzanne M. Ponik, Ying Ge, Song Jin   +7 more
wiley   +1 more source

DNA repair and synthetic lethality [PDF]

International Journal of Oral Science, 2011
Tumors often have DNA repair defects, suggesting additional inhibition of other DNA repair pathways in tumors may lead to synthetic lethality. Accumulating data demonstrate that DNA repair-defective tumors, in particular homologous recombination (HR), are highly sensitive to DNA-damaging agents. Thus, HR-defective tumors exhibit potential vulnerability
Simon Powell
exaly   +4 more sources

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DNA Recognition by Synthetic Constructs

ChemBioChem, 2011
AbstractThe interaction of transcription factors with specific DNA sites is key for the regulation of gene expression. Despite the availability of a large body of structural data on protein–DNA complexes, we are still far from fully understanding the molecular and biophysical bases underlying such interactions. Therefore, the development of non‐natural
Jesus Mosquera Mosquera, M Eugenio Vazquez, Elena Pazos   +2 more
exaly   +3 more sources

Synthetic vehicles for DNA vaccination

Journal of Drug Targeting, 2009
DNA vaccination is an attractive immunization method able to induce robust cellular immune responses in pre-clinical models. However, clinical DNA vaccination trials performed thus far have resulted in marginal responses. Consequently, strategies are currently under development to improve the efficacy of DNA vaccines. A promising strategy is the use of
van den Berg, J.H., Nuijen, B., Schumacher, T.N., Haanen, J.B., Storm, G., Beijnen, J.H., Hennink, W.E.   +6 more
openaire   +3 more sources

IT for synthetic biology and DNA nanotechnology

XRDS: Crossroads, The ACM Magazine for Students, 2010
Somewhere between the studies of information technology and organic chemistry, researchers are trying to make tiny robots out of DNA molecules.
Masami Hagiya, Fumiaki Tanaka, Ibuki Kawamata   +2 more
openaire   +1 more source

The assessment of DNA-synthetic activity

Histochemistry, 1981
A method is described by which a numerical value can be assigned to the amount of DNA-synthesis shown graphically by population-histograms obtained by Feulgen cytophotometry. The index appeared to give a reasonable measure of DNA-synthetic activity in populations having very low, moderate and high mitotic indices and closely followed labelling indices ...
L A, Coulton, B, Henderson, J, Chayen
openaire   +2 more sources

Synthetic DNA delivery systems

Nature Biotechnology, 2000
The ability to safely and efficiently transfer foreign DNA into cells is a fundamental goal in biotechnology. Toward this end, rapid advances have recently been made in our understanding of mechanisms for DNA stability and transport within cells. Current synthetic DNA delivery systems are versatile and safe, but substantially less efficient than ...
D, Luo, W M, Saltzman
openaire   +2 more sources

Electrotransformation of Highly DNA-RestrictiveCorynebacteriawith Synthetic DNA

Plasmid, 1996
Highly DNA-restrictive Corynebacteria can be transformed with DNA made in vitro by PCR amplification of a sequence that contains the replication origin of pBL1, a plasmid common to many Corynebacteria. In all strains examined, the transformation efficiencies of PCR-synthetized DNA equal or improve the performances of heterologous DNA extracted from ...
S, Ankri, O, Reyes, G, Leblon
openaire   +2 more sources