Results 261 to 270 of about 2,867,164 (299)
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Polymorphism of a synthetic DNA in solution
Nature, 1976EARLY work on the X-ray diffraction of DNA fibres showed that DNA can adopt different conformations, and up to now at least four different double-helical models have been described in detail: the A, B, C, and D forms1–4. During recent years, it has become likely that DNA in solution also occurs in different conformations5–7.
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1998
Analytical techniques that exploit the phenomenon of sequence-specific hybridization between nucleic acids have been workhorses of modern molecular biology. With the exponentially increasing rate of genomic sequencing has come a need for hybridization techniques that can keep pace with this vast amount of information.
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Analytical techniques that exploit the phenomenon of sequence-specific hybridization between nucleic acids have been workhorses of modern molecular biology. With the exponentially increasing rate of genomic sequencing has come a need for hybridization techniques that can keep pace with this vast amount of information.
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Nature Biotechnology, 2018
An enzymatic approach to oligonucleotide synthesis promises to extend the length and fidelity of synthetic ...
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An enzymatic approach to oligonucleotide synthesis promises to extend the length and fidelity of synthetic ...
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Error Correction Techniques in Synthetic Oligonucleotides and Synthetic DNA
Molecular BiologyMethods for correcting errors in synthetic oligonucleotides and genetic constructs derived from them are described. Methods for isolating oligonucleotides with a perfect structure from oligonucleotide pools are discussed. Methods for correcting errors in the DNA structure using mismatch-specific endonucleases and proteins of the bacterial DNA repair ...
A N, Sinyakov, E V, Kostina
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NMR study of a synthetic DNA hairpin
Biochemistry, 1986The secondary structure of the synthetic oligodeoxyribonucleotide d(CGCGCGTTTTCGCGCG) (I) has been demonstrated to be a unimolecular hairpin structure (hairpin I) over a wide range of oligonucleotide concentrations (2 X 10(-5) to 1.6 X 10(-3) M) and temperature (0-87 degrees C).
S, Ikuta +4 more
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DNA Adduct-Directed Synthetic Nucleosides
Accounts of Chemical Research, 2019Chemical damage to DNA is a key initiator of adverse biological consequences due to disruption of the faithful reading of the genetic code. For example, O6-alkylguanine ( O6-alkylG) DNA adducts are strongly miscoding during DNA replication when the damaged nucleobase is a template for polymerase-mediated translesion DNA synthesis.
Michael H. Räz +3 more
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Nature Biotechnology, 2010
The complete set of tools needed to synthesize a functional genome and transplant it into a mycoplasma cell opens up the possibility of mixing and matching natural and synthetic DNA to make genomes with new capabilities.
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The complete set of tools needed to synthesize a functional genome and transplant it into a mycoplasma cell opens up the possibility of mixing and matching natural and synthetic DNA to make genomes with new capabilities.
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Binding of netropsin to DNA and synthetic polynucleotides
Molecular Biology Reports, 1974The interaction of netropsin with DNA and synthetic polydeoxyribonucleotides was studied by absorption spectrophotometry and circular dichroism. The results are consistent with a model in which a netropsin molecule occupies five base pairs in binding and carries three reaction sites each capable of interacting with one AT base pair.
A S, Zasedatelev +3 more
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Characterization of synthetic rabbit globin DNA
Archives of Biochemistry and Biophysics, 1973Abstract Synthetic DNA (cDNA) complementary to purified mRNA has already proven to be a useful hybridization probe for the quantitation of specific genes and for the detection of specific mRNAs in eukaryotic organisms. In view of its central role in such studies, it seemed necessary to characterize further one such cDNA and to determine the value of ...
J, Ross, H, Aviv, P, Leder
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Topological Transformations of Synthetic DNA Knots
Biochemistry, 1995Two synthetic DNA molecules that can be knotted have been employed as substrates for E. coli DNA topoisomerases I and III. Both molecules contain 104 nucleotides, including sequences that can form two single-turn helical domains, connected by single-stranded oligo(dT) linkers in an X-Y-X'-Y' pairing motif. One of the knots can be ligated to form cyclic
S M, Du +3 more
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